Skip to main content
SpringerLink
Log in
Book cover

Role of Melatonin and Pineal Peptides in Neuroimmunomodulation pp 253–261Cite as

Melatonin, Immunity and Cancer in Humans

  • Chapter

Part of the book series: NATO ASI Series ((NSSA,volume 204))

Abstract

Science, medicine and social development are progressing hand in hand. Science and medicine or social situation which were believed to be self-contained endogenously regulated areas are now seen to be closely intregrated and cast penetrating influence on one another. Close observations illuminate how social problems slowly transform into medical problems: Following examples indicate the existence of this communication network:

  • Life crisis or social stress diminishes the immune response;

  • Specific mental disturbances are accompanied by immune abnormalities;

  • Some immunological disorders produce psycho-social symptoms;

  • Stressful childhood experiences have immunological consequences.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lapin, V. 1976. Pineal gland and malignancy. Öster.Z. Onkol. 3: 51

    CAS  Google Scholar 

  2. Blask, D., and Hill, S., 1986. Effects of melatonin on cancer: studies on MCF-7 human breast cancer cells in culture. J.Neural Transm. (Suppl.) 21: 433.

    CAS  Google Scholar 

  3. Walker, M.J., Chaudhuri, P.K., Beattie, C.W., Tito, W.A. and Das Gupta, T.K. 1978. Neuroendocrine and endocrine correlates to hamster melanoma growth in vitro. Surg.Forum. 29: 152.

    Google Scholar 

  4. Shah, P., Mhatre, M. and Kothari, L. 1984. Effect of melatonin on mammary carcinogenesis in intact and pinealectomized rats in varying photoperiods. Cancer Res. 44: 3403.

    PubMed  CAS  Google Scholar 

  5. Cohen, M., Lippman, M. and Chabner, B. 1978. Role of the pineal gland in aetiology and treatment of breast cancer. Lancet 2: 814.

    Article  PubMed  CAS  Google Scholar 

  6. Svet-Moldarsky, G.J., Veskova, T.K., Slavina, E.G., Bychkov, M.B., Perevodchikova, N.I., Lichynister, M.R., Trapenznikov, N.N., Javorksy, N., Muchoedova, S.N., and Ravkina, L.I. 1976. An attempt of treatment of malignant malinoma with bovine pineal tissues. Biomedicine 25:7.

    Google Scholar 

  7. Tamarkin, L., Cohen, M., Rosell, D., Reichert, C., Lippman, M. and Chabner B. 1981. Melatonin inhibition and pinealectomy enhancement of 7, 12-dimethylbenz(a)anthracene-induced mammary tumors in the rat. Cancer Res. 41: 4432.

    PubMed  CAS  Google Scholar 

  8. Blask, D.E. 1984. The pineal and oncostatic gland. Pages 253., in Reiter, R.J. (ed.) The Pineal Gland. Raven Press, New York.

    Google Scholar 

  9. Blask, D.E. and Leadem, C.A. 1987. Neuroendocrine aspects of neoplasia: a review. Neuroendocrinol.Lett. 9: 63.

    CAS  Google Scholar 

  10. Rodin, A.E. 1963. The growth and spread of Walker 256 carcinoma in pinealectomized rats. Cancer Res. 23: 1545.

    PubMed  CAS  Google Scholar 

  11. Das Gupta, T.K. and Terz, J. 1967. Influence of pineal gland on the growth and spread of melanom in the hamster. Cancer Res. 27: 1306.

    PubMed  Google Scholar 

  12. Cogburn L.A. and Glick, B.. 1983. Functional lymphocytes in the chicken pineal gland. J.Immunol. 130: 2109.

    PubMed  CAS  Google Scholar 

  13. Jankovic, B.D. and Spector, N.H. 1986. Effects on the immune system of lesioning and stimulation of the nervous system: Neuroimmunomodulation. Pages 189, in Plotnikoff, N.P., Faith, R.E., Murgo, A.J. and Good, R.A. (eds.) Enkephalins and Endorphins: Stress and the Immune system. Plenum Press, New York.

    Google Scholar 

  14. Sano, K. 1976. Diagnosis and treatment of tumors in the pineal region. Acta Neurochir. 34: 153.

    Article  CAS  Google Scholar 

  15. Neuwelt, E.A., Glasberg, M., Frankel, E. and Clark, W.K. 1979. malignant pineal region tumors. J.Neurosurq. 51:597.

    Article  CAS  Google Scholar 

  16. Reiter, R.J. 1986: Funktionelle Morphologie und Pathophysiologie der Zirbeldrüse. Pages 53, in Gupta, D. (ed.) Endokrinoloqie der Kindheit und Adoleszenz. Thieme Verlag, Stuttgart.

    Google Scholar 

  17. Vuia, O. 1980. Embryonic carcino-sarcoma (mixed tumor) of the pineal gland. Neurochirurgie 23: 47.

    CAS  Google Scholar 

  18. Fuchsberger, A., Sieverts, H., Schröder, R., Harbott, J. and Berthold, F. 1990. Myelosarkom (Monozytom) des Corpus pineale als Primärmanifestation einer akuten Monozyten-Leukämie. Tumordiagn. u. Ther. 11: 90.

    Google Scholar 

  19. Bartsch, C., Bartsch H., Flüchter, S.H., Harzmann, R., Attanasio, A., Bichler, K.H. and Gupta, D. 1983. Circadian rhythm of serum melatonin, prolactin and growth hormone in patients with benign and malignant tumors of the prostate and in non-tumor controls. Neuroendocrinol.Lett. 5:377.

    Google Scholar 

  20. Relkin, R., 1976. The pineal and human disease. Pages 76 in Relkin, R. (ed.) Annual Res. Rev. The Pineal. Lundsdale House Hornby, Lancaster, England.

    Google Scholar 

  21. Bartsch, C., Bartsch, H., Fuchs, U., Lippert, T.H., Bell-mann, and Gupta, D. 1989: Stage-dependent depression of melatonin in patients with primary breast cancer. Cancer 64: 426.

    Article  PubMed  CAS  Google Scholar 

  22. Fernandes, G., Carandente, F., Halberg, E., Halberg, F. and Good, A. 1979. Circadian rhythm in activity of lympholytic natural killer cells from spleens of Fisher rats. J.Immunol. 123: 622.

    PubMed  CAS  Google Scholar 

  23. Gatti, G., Cavallo, R., Delponte, D., Sartori, M.L., Masera, R., Carignola, R., Carradente, F. and Angeli, A. 1986. Circadian changes of human natural killer (NK) cells and their in vitro susceptibility to cortisol inhibition. Ann.Rev.Chronopharmacol. 3: 75.

    CAS  Google Scholar 

  24. Bartsch, H., Bartsch, C. and Gupta, D. 1990. Seasonal variations of endogenous defence mechanisms against cancer. Pages 333. In Gupta, D., Wollmann, H.A. and Ranke, M.B. (eds.) Neuroendocrinology: New Frontiers, Brain Research Promotion, Tübingen-London.

    Google Scholar 

  25. Kuci, S., Becker, J., Veit, G., Handgretinger, R., Attanasio, A., Bruchelt, G., Treuner, J., Niethammer, D. and Gupta, D. 1988. Circadian variations in the immunomodulatory role of the pineal gland. Neuroendocrinol.Lett. 10: 65.

    CAS  Google Scholar 

  26. Johnson H.M., Smith E.M., Torres, B.A., and Blalock, J.E. (1982) Regulation of the in vitro antibody response by neuroendocrine hormones. Proc.Natl.Acad.Sci., USA, 79: 4171.

    Article  PubMed  CAS  Google Scholar 

  27. Johnson, H.M., Torres, B.A., Smith, E.M., Dion, L.D., and Blalock, J.E. (1984): Regulatin of lymphokine (y-interferon) production by corticotropin. J.Immunol. 132:246.

    PubMed  CAS  Google Scholar 

  28. Avarez-Mon, M., Kehrl, J.H., and Fanci, A.S. 1985. A potential role for adrenocorticotropin in regulating human ß lymphocyte function. J.Immunol. 135: 3832.

    Google Scholar 

  29. Fraschini, F., Esposti, D., Lissoni, P., Viviani, S., Espoti, G., Lucini, V., Ripamonti, L. and Scaglione, F. 1988. In Gupta, D., Attanasio, A. and Reiter, R.J. (eds.) The Pineal Gland and Cancer. Brain Research Promotion. Tübingen: London.

    Google Scholar 

  30. Gupta, D. 1990. An integrated communication network between the immune and neuroendocrine systems. Pages 265, in Gupta, D., Wollmann, H.A., and Ranke, M.B. (eds.) Neuroendocrinology: New Frontiers. Brain Res.Promotion: Tübingen: London.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Diagnostic Endocrinology, University Children’s Hospital, D-7400, Tübingen, W.Germany

    D. Gupta

Authors
  1. D. Gupta
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Milan, Milan, Italy

    Franco Fraschini

  2. The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

    Russel J. Reiter

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Gupta, D. (1991). Melatonin, Immunity and Cancer in Humans. In: Fraschini, F., Reiter, R.J. (eds) Role of Melatonin and Pineal Peptides in Neuroimmunomodulation. NATO ASI Series, vol 204. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3756-4_29

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3756-4_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6673-7

  • Online ISBN: 978-1-4615-3756-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation