Abstract
Substantial evidence now exists that the normal course of immunologic defense reactions in an organism is determined by the coordinated interrelationship between the neuroendocrine and immune systems, mediated by common receptors and ligands. Immunomodulatory influences of the central nervous system (CNS) occur via operation of neural, hormonal, neuromediator and neuropeptide mechanisms and are accomplished through “strategic” and “tactical” forms of regulation (Korneva, 1989). The former maintains the initial potential of the immune system and is associated with bone marrow production of precursor stem cells. The latter is linked with local changes in functional activity of mature immunocytes occurring at any particular moment. CNS dysfunction may affect both types, resulting in lower host resistance.
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Lesnikov, V.A., Isaeva, E.N., Korneva, E.A., Pierpaoli, W. (1991). Melatonin Reconstitutes the Decreased CFU-S Content in the Bone Marrow of Hypothalamus-Lesioned Mice. In: Fraschini, F., Reiter, R.J. (eds) Role of Melatonin and Pineal Peptides in Neuroimmunomodulation. NATO ASI Series, vol 204. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3756-4_25
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DOI: https://doi.org/10.1007/978-1-4615-3756-4_25
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