Abstract
Melatonin /5-methoxy-N-acetyltryptamine/ is a lipid-soluble derivative of 5-hydroxytryptamine, which is produced normally in the pineal gland under the influence of sympathetic neural tone which is in turn governed by photoperiodic impacts. Melatonin secretion is maximal after the onset of darkness and its role in mediating photoperiodically regulated seasonal changes in reproductive activity and metabolism has been well established in most of the mammals studied so far /Goldman & Darrow, 1983; Stetson & WatsonWhitmyre, 1984/. Studies in rodents suggest that the biological effects of melatonin may be mediated by binding of melatonin to putative membrane receptors in target organs /Duncan et al., 1988; Cardinali et al., 1979; Cardinali & Vacas, 1981/.
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References
Bockaert, M., Hunzicker-Dunn, M., and Birnbaumer, L., 1976, Hormone-stimulated desensitization of hormone-dependent adenylyl cyclase, J. of Biol. Chem. 251:2653
Caldwell, K., Blake, E., and Sensabaugh G., 1976, Sperm diaphorase. Genetic polymorphism of sperm specific enzyme in man, Science, 191:1185
Cardinali, D., Vacas, M., and Estevez-Beyer, E., 1979, Specific binding of melatonin in bovine brain, Endocrinol. 105:437
Cardinali, D., Vacas, M., 1981, Molecular endocrinology of melatonin: receptors sites in brain and peripheral organs, Adv. Biosci. 29:237
Davis, B., 1964, Disc electrophoresis. II Method and application to human serum proteins. Ann. N.Y. Acad. Sci. 121:404
Dousa, T., Barnes, L., Ong, S., and Steiner, A., 1977, Immunohistochemical localization of 3:5-cyclic AMP and 3:5-cyclic GMP in rat renal cortex: Effect of parathyroid hormone, Proc. Nat. Acad. Sci. USA, 74:3569
Duncan, M., Takahashi, J., and Dubocovich, M., 1988, 2-(125I) Iodomelatonin binding sites in hamster brain membranes: Pharmacological characteristics and regional distribution, Endocrinol. 122:1825
Fraser, S., Caven, P., Franklin, M., Franey, C., and Arend, J., 1983, Direct assay for melatonin in plasma. Clin.Chem. 29:396
Goldman, B., and Darrow, J., 1983, The pineal gland and mammalian photoperiodism. Neuroendocrinol. 37:386
Kopin, I., Pare, C., Axelrod, J., and Weissbach, H., 1961, The fate of melatonin in animals. J. Biol. Chem. 236:3072
Krieger, I., 1987, The Pineal Gland, in: Endocrinology and Metabolism, Ph. Felig, J Baxter, H. Broadus, and L. Frohman, eds., Mc Graw-Hill Book Company, New York
Morgan, P., Lawson, W., Davidson, G., and Howell, H., 1989 Melatonin inhibits cyclic AMP production in cultured ovine pars tuberalis cells, J. Mol. Endocrinol. 3, R5
Miner, G., and Heston, L., 1972, Method for acrylamide gel isoelectricfocusing of insoluble brain proteins, Anal. Biochem. 50:313
Onoda, M., and Hall, P., 1982, Cytochrome b-5 stimulates purified testicular microsomal cytochrome P-450 (side-chain cleavage), Biochem. Biophys. Res. Comm. 108:454
Persengiev, S., Kanchev, L., and Stankov, B., 1989, Effect of melatonin on steroid production by rat adrenals under in vitro superfusion condition, Life Sci.44:1955
Stadel, J., De Lean, A., and Lefkovitz, R., 1982, Molecular mechanism or coupling in hormone receptor-adenilate cyclase systems. in: Advances in Endocrinology, vol.53, A. Meister, ed., John Willey & Sons, Inc.
Steiner, A., Kopnis, D., Utiger, R., and Parcer, C., 1969, Radioimmunoassay for the measurement of adenosine 3,5-cyclic phosphate. Proc. Nat. Acad. Sci. USA, 64:364
Stetson, M., and Watson-Whitmyre, M., 1984, Physiology of pineal hormone melatonin in annual reproduction in rodents, in: The Pineal Gland, R. Reiter, ed., Raven Press, New York
Van Cauter, E., and Honincks, E., 1985, Pulsatility of pituitary hormones, Experim. Brain Res., Suppl. 12:41
Wurtman, R., Altschule, M., and Holmgren, U., 1959, Effect of pinealectomy and of a bovine pineal extract in rats, Am. J. Physiol. 197:108
Wu, W., Reiter, R., Troini, M., and Vaughan, G., 1987, Elevated daytime rat pineal and serum melatonin levels induced by isoproterenal are depressed by swimming, Life Sci. 41:1473
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Persengiev, S.P., Atanasov, B., Kanchev, L.N. (1991). Effect of Melatonin on NaDH-Oxidoreductase Activity and Cyclic Nucleotide Levels in Rat Adrenals. In: Fraschini, F., Reiter, R.J. (eds) Role of Melatonin and Pineal Peptides in Neuroimmunomodulation. NATO ASI Series, vol 204. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3756-4_18
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DOI: https://doi.org/10.1007/978-1-4615-3756-4_18
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