Abstract
In recent years there has been an increase in the number of studies which have examined the growth of vascular endothelial cells. A major reason for this interest stems from the clinical data which shows that vascular prostheses are rarely endothelialized (1–5), and perhaps this fact alone is responsible for the occlusion of many grafts. There is also concern as to whether arteries subjected to angioplasty ever achieve total re-endothelialization. This chapter will deal with aspects controlling endothelial cell growth with a particular emphasis on growth of these cells in vivo.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Reidy, M.A. 1988. Endothelial regeneration. VIII. Interaction of smooth muscle cells with endothelial regrowth. Lab. Invest. 59: 36–43.
Berger, K., Sauvage, L.R., Rao, A.M., et al. 1972. Healing of arterial prostheses in man: its incompleteness. Ann. Surg. 175: 118–127.
Sauvage, L.R., Berger, K.E., Wood, S.J., et al. 1974. Interspecies healing of porous arterial prostheses. Arch. Surg. 109: 698–705.
Reidy, M.A., Clowes, A.W. and Schwartz, S.M. 1983. Endothelialization regeneration. V. Inhibition of endothelial regrowth in arteries of rat and rabbit. Lab. Invest. 49: 569–575.
Lindner, V., Reidy, M.A. and Fingerle, J. 1989. Regrowth of arterial endothelium. Denudation with minimal trauma leads to complete endothelial cell regrowth. Lab. Invest. 61: 556–563.
Schwartz, S.M., Stemerman, M.B. and Benditt, E.P. 1975. The aortic intima. II. Repair of the aortic lining after mechanical denudation. Am. J. Pathol. 81: 15–42.
Reidy, M.A. and Schwartz, S.M. 1981. Endothelial regeneration. III. Time course of intimai changes after small defined injury to rat aortic endothelium. Lab. Invest. 44: 301–308.
Reidy, M.A., Standaert, D. and Schwartz, S.M. 1982. Inhibition of endothelial cell regrowth. Cessation of aortic endothelial cell replication after balloon catheter denudation. Arteriosclerosis 2: 216–220.
Goff, S.G., Wu, H.D., Sauvage L.R., et al. 1988. Differences in reendothelialization after balloon catheter removal of endothelial cells, superficial endarterectomy, and deep endarterectomy. J. Vasc. Surg. 7: 119–129.
Reidy, A.M., Chao, S.S., Kirkman, T.R. and Clowes, A.W. 1986. Endothelial regeneration. VI. Chronic nondenuding injury in baboon vascular grafts. Am. J. Pathol. 123: 432–439.
Haudenschild, C.C. and Schwartz, S.M. 1979. Endothelial regeneration. II. Restitution of endothelial continuity. Lab. Invest. 41: 407–418.
Orlidge, A. and D’Amore, P.A. 1987. Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells. J. Cell Biol. 105: 1455–1462.
Antonelli-Orlidge, A., Saunders, K.B., Smith, S.R., et al. 1989. An activated form of transforming growth factor beta is produced by co-culture of endothelial cells and pericytes. Proc. Natl. Acad. Sci. USA 986: 4544–4548.
Lindner, V., Majack, R.R. and Reidy, M.A. 1990. Basic FGF stimulates endothelial regrowth and proliferation in denuded arteries. J. Clin. Invest. in press.
Reidy, M.A. and Schwartz, S.M. 1983. Endothelial injury and regeneration. IV. Endotoxin: a nondenuding injury to aortic endothelium. Lab. Invest. 48: 25–34.
Reidy, M.A., Chopek, M., Chao, S., et al. 1989. Injury induces increase in von Willebrand Factor in rat endothelial cells. Am. J. Pathol. 134: 857–864.
Gospodarowicz, D., Ferrara, N., Haaparanta, T. and Neufeld, G. 1988. Basic fibroblast growth factor: expression in cultured bovine vascular smooth cells. Eur. J. Cell Biol. 46: 144–151.
Lindner, V., Majack, R.A. and Reidy MA. 1989. Basic FGF stimulates endothelial regrowth in denuded arteries in vivo. J. Cell Biol. 109: 98a.
Lindner, V., Majack, R.A. and Reidy, M.A. 1990. Basic FGF induces the proliferation of vascular cells in injured arteries. FASEB J. 4: A623.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Reidy, M.A., Lindner, V. (1991). Repair of Arterial Endothelium. In: Gotlieb, A.I., Langille, B.L., Fedoroff, S. (eds) Atherosclerosis. Altschul Symposia Series, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3754-0_5
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3754-0_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6672-0
Online ISBN: 978-1-4615-3754-0
eBook Packages: Springer Book Archive