Abstract
This paper focuses on photocarcinogenesis and non-melanoma skin cancer in man and discusses facts and theories on the role of the immune system for this process. Since photocarcinogenesis in man is closely connected with sun-exposure no details on the role of the specific wavelengths of UV radiation will be discussed.
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References
Ananthaswamy, H.N., Price, J.E., Goldberg, L.H., Bales, E.S. (1988), Detection and identification of activated oncogenes in human skin cancers occurring on sun-exposed body sites, Cancer Res. 48:3341–3346.
Bohr, V.A., Okumoto, D.S., Hanawalt, P.C.,(1986), Survival of UV-irradiated mammalian cells correlates with efficient DNA repair in an essential gene. Proc. Natl. Acad. Sci. USA 83:3830–3833.
Cleaver, J. (1968), Defective repair replication of DNA in Xeroderma pigmentosum, Nature 218:652–656.
Dubreuilh, W. (1896), Des hyperkeratoses circonscriptes, Ann. Dermatol. Syph (Series 3) 7:1158–1204.
Epstein, J.H., Roth, H.L. (1968), Experimental ultraviolet carcinogenesis: a study of croton oil promoting effects. J. Invest. Dermatol. 50:387–389.
Frentz, G, Munch-Petersen, B., Wulf, H.C., Niebuhr, E., da Cunha Bang, F. (1987), The nevoid basal cell carcinoma syndrome: sensitivity to ultraviolet radiation and X-rays, J. Am Acad. Dermatol. 17:637–643.
Frentz, G., dan Cunha Bang, F., Munch-Petersen, B., Lange, Wantzin, G. (1988), Increased number of circulating suppressor T-lymphocytes in sun-induced multiple skin cancers. Cancer 61: 294–297.
Guillen, F.J., Calvin, L. Day Jr, Murphy, G.F., (1985), Expression of human lymphocyte antigen (HLA)-DR on tumor cells in basal cell carcinoma, J. Am. Acad. Dermatol. 85:203–206.
Gupta, A.K., Cardella, C.J., Habermann, H.F. (1986), Cutaneous malignant neoplasms in patients with renal transplants, Arch. Dermatol. 122:1288–1293.
Habets, J.M.W., Tank, B., Vuzevski, V.D., van Reede, E.C., Stolz, E., van Joost, T. (1988), Characterization of the mononuclear infiltrate in basal cell carcinoma: a predominantly Tcell-mediated immune response with minor participation of Leu-7+ (natural killer) cells and Leu-14+ (B) cells. J. Invest. Dermatol. 90:289–292.
Hersey, P., Haran, G., Hasic, E., Edwards, A. (1983), Alteration of T-cell subsets and induction of suppressor T-cell activity in normal subjects after exposure to sunlight, J. Immunol. 31:171–174.
Hersey, P., Bradley, M., Hasic, E., Haran, G., Edwards, A., McCarthy, W.H. (1983), Immunological effects of solarium exposure in human subjects, Lancet 1:545–548.
Hersey, P., MacDonald, M., Burns, C., Schibeci, S., Matthews, H., Wilkinson, F.J. (1987), Analysis of the effect of a sunscreen agent on the suppression of natural killer cell activity induced in human subjects by radiation from solarium lamps, J. Invest. Dermatol. 88:271–276.
Hersey, P., MacDonald, M., Henderson, C., Schibeci, S., d’Allesandro, G., Pryor, M., Wilkinson, F.J. (1988), Suppression of natural killer cell activity in humans b y radiation from solarium lamps depleted of UVB, J. Invest. Dermatol. 90:305–310.
Kochiyama, A, Oka, D., Ueki, H. (1986), Immunohistologic studies of squamous cell carcinoma: possible participation of Leu-7+ (natural killer) cells as antitumor effector cells, J. Invest. Dermatol. 87:515–518.
Kochiyama, A., Oka, D., Ueki, H. (1987), Expression of human lymphocyte antigen (HLA)-DR on tumor cells in basal cell carcinoma, J. Am. Acad. Dermatol. 16:833–838.
Kripke, M.K. (1986), Immunology and photocarcinogenesis, New light on an old problem, J. Am. Acad. Dermatol. 14:149–155.
Munch-Petersen, B., Frentz, G. (1985), X-ray and UV-radiation sensitivity of circulating lymphocytes in multiple epidermal cancer in relation to previous radiation exposure, Rad. Res. 103:432–440.
Urbach, F. (1969), Geographic pathology of skin cancer, in Urbach F., ed: The biologic effects of ultraviolet radiation, Pergamon Press, Oxford, pp. 635–650.
Unna, P.G. (1894), Die histopathologie der hautkrankheiten, Berlin, A. Hirschwald.
Yagi, H., Danno, K., Maruguchi, Y., Yamamoto, M., Imamura, S. (1987), Significance of squamous cell carcinoma (SCC)-related antigens in cutaneous SCC. Arch. Dermatol. 123:902–906.
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© 1991 Springer Science+Business Media New York
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Frentz, G. (1991). Immunology of UV-Induced Human Skin Cancer. In: Riklis, E. (eds) Photobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3732-8_80
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DOI: https://doi.org/10.1007/978-1-4615-3732-8_80
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6661-4
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