Ultraviolet Radiation Induces Cytoskeletal Damage in Human Cells

Abstract

Solar ultraviolet (UV) radiation is the major cause of skin cancer and contributes to the deterioration of dermal connective tissue associated with aging. It is therefore important to identify the UV induced lesions which alter normal cellular functions. Although genetic damage may be an important initiating factor in the carcinogenic process, epigenetic phenomena are also likely to play a role in the development of neoplasia. Current evidence indicates that lesions other than pyrimidine dimers are involved in the carcinogenic, mutagenic and lethal effects of UV radiation which reaches the earth’s surface (Zamansky, 1986 and references therein). Although investigators continue to seek additional DNA lesions which may contribute to these pathogenic phenomena, the importance of UV induced alterations of other cellular components must also be considered.