Abstract
Pyrimidine dimers, the major photodamage formed in DNA at 254 nm light, are the classic “test lesions” used for the analysis of DNA repair processes at the molecular level. Three dissimilar enzymatic systems, which initiate repair of pyrimidine dimers, have been described so far: namely photoreactivating enzyme, pyrimidine dimer DNA glycosylase, and the multiprotein Uvr ABC incision system (Grossman et al., 1988). Although the mechanism of action of these enzymes is different, all these proteins have to sense the unique structural change imposed to DNA by this damage. To obtain insight in the recognition mechanism of pyrimidine dimers by these very different enzymatic systems, it is important to know how these lesions affect B-DNA structure.
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References
Broyde, S., Stellman, S., and Hingerty, B. (1980) Biopolymers, 9, 1965.
Ciarrocchi, G. and Pedrini A.M. (1982) J. Mol. Biol., 155, 177.
Ciarrocchi, G., Sutherland, B.M. and Pedrini A.M.(1982) Biochimie, 64, 665.
Di Nardo, S., Voelkel, K.A., Sternglanz, R., Reynolds, A.E. and Wright, A. (1983) Cold Spring Harbour Symp. Quant. Biol., 47, 779.
Grossman, L., Caron, P.L., Mazur, S.J. and OH, E.Y. (1988) FASEB J., 2, 2696.
Hayes, F.N., Williams, D.L., Ratliff, R.L., Varghese, A.J. and Rupert, C.S. (1971) J. Am. Chem. Soc., 93, 4940.
Kemmink, J., Boelens, R., Koning, T.M.G., Kaptein, R., van der Marel, G.A. and van Boom, J.H. (1987) Eur. J,., Biochem.,162, 37.
Overby, K.M. and Margolin, P. (1981) J. Bacteriol., 146, 170.
Pearlman, D.A., Hoibrook, S.R., Pirkle, D.H. and Kim, S.H. (1985) Science, 227, 1304.
Pedrini, A.M. (1984) In: “Proteins Involved in DNA Replication”. U. Hubscher and S. Spadari (eds.) Plenum Publishing Co., pp. 449–454.
Pedrini, A.M. and Ciarrocchi, G. (1983) Proc. Natl. Acad. Sci. USA, 80, 1787.
Pedrini, A.M., Tornaletti, S., Barabino, S., Menichini, P., Fronza, G. and Abbondandolo, A. (1989) In: “Cellular Responses to DNA Damage”. M. Bignami, E. Dogliotti and J.M. Essigmann (eds.) Ann. Ist. Super. Sanità, 25, pp. 91–98.
Pedrini, A.M., Tornaletti, S., Menichini, P. and Abbondandolo, A. (1986). In: “Mechanisms of DNA Damage and Repair: Implication for Carcinogenesis and Risk Assessment”. M.G. Simic, L. Grossman and A.C. Upton (eds.) Basic Life Sci., 38, pp. 295–301.
Rao, S.N., Keepers, J.W. and Kollman, P. (1984) Nucleic Acids Res., 12, 4789.
Shafranovskaya, N.N., Trifonov, E.N., Lazurkin, Yu.S., and Franck-Kamenetskii, M.D. (1973) Nature New Biology 241, 58.
Wang, J.C. (1985) Annu. Rev. Biochem., 54, 665.
Wang, J.C.(1979) Proc. Natl. Acad. Sci. USA, 76, 200.
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Pedrini, A.M., Spirito, F., Tornaletti, S. (1991). UV-Light Induced Perturbation of DNA Tertiary Structure: Consequences on the Enzymes Controlling Chromosome Superhelicity. In: Riklis, E. (eds) Photobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3732-8_17
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DOI: https://doi.org/10.1007/978-1-4615-3732-8_17
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