Abstract
Inhibitors of eubacterial and eucaryotic DNA topoisomerases II induce topological changes and/or DNA cleavage in the plasmids of halobacteria. As in eubacteria, novobiocin halts DNA replication and induces positive supercoiling of plasmids in halobacteria. This positive supercoiling is prevented by actinomycin D, indicating that it may be generated by transcription as in eubacteria.
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Forterre, P., Gadelle, D., Charbonnier, F., Sioud, M. (1991). DNA Topology in Halobacteria. In: Rodriguez-Valera, F. (eds) General and Applied Aspects of Halophilic Microorganisms. NATO ASI Series, vol 201. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3730-4_40
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DOI: https://doi.org/10.1007/978-1-4615-3730-4_40
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