Skip to main content
SpringerLink
Log in
Book cover

Cellular Signals Controlling Uterine Function pp 107–117Cite as

Glycoprotein Expression and Function in Embryo-Uterine Interactions

  • Chapter

  • 56 Accesses

Summary

The interactions that occur among embryonic and uterine cells during the implantation process are dramatic examples of highly-regulated cell adhesion events. Evidence has accumulated over the past few years implicating the involvement of glycoproteins of both embryonic and uterine cell surfaces in these interactions. Notably, heparan sulfate proteoglycans (HSPG), integrins, lactosaminoglycans and their receptors as well as a variety of other components of the extracellular matrix have the capacity to support aspects of cell adhesion in this system. From the standpoint of the embryo, glycoprotein expression appears to be regulated by the developmental clock of the embryo, such that HSPG- and integrindependent cell adhesion systems are expressed early relative to certain other cell adhesion systems. In the uterus, there appear to be a number of factors that influence patterns of glycoprotein expression. These include steroid hormones, maturational factors and potential embryonic influences. Uterine epithelial cells are even more complex with regard to regulation of glycoprotein expression. In addition to the considerations described above, the apical and basolateral cell surface domains of uterine epithelial cells exhibit a marked difference in their respective patterns of glycoprotein expression. Furthermore, different glycoproteins are metabolized at different rates and by different pathways within these cells. Collectively, it appears that glycoprotein expression by the embryo and the uterus is quite dynamic. This property is likely to have important consequences with regard to the cell-cell interactions that occur during implantation.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anderson, T. L., Hoffman L. H., Alterations in epithelial glycocalyx of rabbit uteri during early pseudopregnancy and pregnancy, and following ovariectomy, Amer. J.Mat. 171:321 (1984).

    CAS  Google Scholar 

  2. Anderson, T. L., Olson, G. E., Hoffman, L., Stage-specific alterations in the apical membrane glycoproteins of endometrial epithelial cells related to implantation in rabbits, Biol. Reprod., 34:701 (1986).

    Article  PubMed  CAS  Google Scholar 

  3. Armant, D. R., Kaplan, H. A., and Lennarz, W. J., N-Linked glycoprotein biosynthesis in the developing mouse embryo, Dev. Biol., 113:228 (1986).

    Article  PubMed  CAS  Google Scholar 

  4. Armant, D. R., Kaplan, H. A., and Lennarz, W. J., Fibronectin and laminin promote in vitroattachment and outgrowth of mouse blastocysts, Dev. Biol., 116:519 (1986).

    Article  PubMed  CAS  Google Scholar 

  5. Armant, D. R., Kaplan, H. A., Mover, H., and Lennarz, W. J., The effect of hexapeptides on attachment and outgrowth of mouse embryo in vitro:Evidence for the involvement of the cell recognition tripeptide Arg-Gly-Asp, Proc. Natl. Acad. Sci. USA, 83:6751 (1986).

    Article  PubMed  CAS  Google Scholar 

  6. Atienza-Samols, S. B., Pine, S. R., and Sherman, M. I., Effects of tunicamycin upon glycoprotein synthesis and development of early mouse embryos, Dev. Biol., 79:19 (1980).

    Article  PubMed  CAS  Google Scholar 

  7. Babiarz, B. and Hathaway, H. J., Hormonal control of the expression of antibody-defined lactosaminoglycans in the mouse uterus, Biol. Reprod., 39:699 (1988).

    Article  PubMed  CAS  Google Scholar 

  8. Benirschke, K., Placentation, J. Exp. Zool., 228:385 (1983).

    Article  CAS  Google Scholar 

  9. Carson, D. D. and Tang, J. P., Estrogen induces N-linked glycoprotein expression by immature mouse uterine epithelial cells, Biochem., 28:8116 (1990).

    Google Scholar 

  10. Carson, D. D., Tang, J. P., and Gay, S., Collagens support embryo attachment and outgrowth in vitro:Effects of the Arg-Gly-Asp sequence, Dev. Biol., 127:368 (1988).

    Article  PubMed  CAS  Google Scholar 

  11. Carson, D. D., Dutt, A., and Tang, J. P., Glycoconjugate synthesis during early pregnancy: hyaluronate synthesis and function, Dev. Biol., 120:228 (1987).

    Article  PubMed  CAS  Google Scholar 

  12. Carson, D. D., Tang, J. P., Julian, J., and Glasser, S. R., Vectorial secretion of proteoglycans by polarized rat uterine epithelial cells, J. Cell Biol., 107:2425 (1988).

    Article  PubMed  CAS  Google Scholar 

  13. Carson, D. D., Tang, J. P., and Hu, G., Estrogen influences dolichylphosphate distribution among glycolipid pools in mouse uteri, Biochemistry, 26:1598 (1987).

    Article  PubMed  CAS  Google Scholar 

  14. Carson, D. D., Wilson, O. F., and Dutt, A., Glycoconjugate expression and interactions at the cell surface of mouse uterine epithelial cells and peri-implantation-stage embryos, Troph. Res. 4:211 (1990).

    CAS  Google Scholar 

  15. Chavez, D. J. and Anderson, T. L., The glycocalyx of the mouse uterine epithelium during estrus, early pregnancy, the peri-implantation period and delayed implantation. I. The acquisition of Ricinus communis I binding sites during pregnancy, Biol. Reprod., 32:1135 (1985).

    Article  PubMed  CAS  Google Scholar 

  16. Cowell, T. P., Implantation and development of mouse eggs transferred to the uteri of non-progestational mice, J. Reprod. Fertil., 19:239 (1969).

    Article  PubMed  CAS  Google Scholar 

  17. Dziadek, M., Fujiwara, S., Paulsson, M., and Timpl, R., Immunological characterization of basement membrane types of heparan sulfate proteoglycan, EMBO J., 4:905 (1985).

    PubMed  CAS  Google Scholar 

  18. Dziadek, M. and Timpl, R., Expression of nidogen and laminin in basement membranes during mouse embryogenesis and in teratocarcinoma cells, Dev. Biol., I11:372 (1985).

    Article  Google Scholar 

  19. Dutt, A., Cooper, J., Stewart, S. L., Farrar, J. D., and Carson, D. D., Regulation of extracellular matrix expression during uterine decidualization [abstract] J. Cell Biol., 107:4538 (1988).

    Google Scholar 

  20. Dutt, A., Tang, J. P., and Carson, D. D., Lactosaminoglycans are involved in uterine epithelial cell adhesion in vitro,Dev. Biol., 119:27 (1987).

    Article  PubMed  CAS  Google Scholar 

  21. Dutt, A., Tang, J. P., and Carson, D. D., Estrogen preferentially stimulates lactosaminoglycan-containing oligosaccharide synthesis in mouse uteri, J. Biol. Chem., 263:2270 (1988).

    PubMed  CAS  Google Scholar 

  22. Dutt, A., Tang, J. P., Welply, J. K., and Carson, D. D.Regulation of N-linked glycoprotein assembly in uteri by steroid hormones, Endocrinology, 118:661 (1986).

    Article  PubMed  CAS  Google Scholar 

  23. Enders, A. C. and Schlafke, S., Surface coats of the mouse blastocyst and uterus during the preimplantation period, Anat. Rec., 180:31 (1974).

    Article  PubMed  CAS  Google Scholar 

  24. Endo, M. and Yosizawa, Z., Hormonal effects on sugar-nucleotides in rabbit uteri, Arch. Biochem. Biophys., 127:585 (1968).

    Article  CAS  Google Scholar 

  25. Farach, M. C., Tang, J. P., Decker, G. L., and Carson, D. D., Heparan/heparan sulfate is involved in attachment and spreading of mouse embryos in vitro, Dev. Biol., 123:401 (1987).

    Article  PubMed  CAS  Google Scholar 

  26. Farach, M. C., Tang, J. P., Decker, G. L., and Carson, D. D., Differential effects of pnitrophenyl-D-xylosides on mouse blastocysts and uterine epithelial cells, Biol. Reprod., 39:443 (1988).

    Article  PubMed  CAS  Google Scholar 

  27. Carson, D.D., Farrar, J. D., Laidlaw and Wright, D.A., Selective activation of 5the Nglycosylation apparatus in uteri by estrogen, J. Biol. Chem., 265:2947 (1990).

    PubMed  CAS  Google Scholar 

  28. Finn, C. A, Implantation, menstruation and inflammation, Biol. Rev., 61:313 (1986).

    Article  PubMed  CAS  Google Scholar 

  29. Fukuda, M., Cell surface glycoconjugates as onco-differentiation markers in hematopoietic cells, Biochim. Biophys. Acta, 780:119 (1985).

    CAS  Google Scholar 

  30. Glasser, S. R., Julian, J., Decker, G. L., Tang, J. P., and Carson, D. D., Development of morphological and functional polarity in primary cultures of immature rat uterine epithelial cells, J. Cell Biol., 107:2409 (1988).

    Article  PubMed  CAS  Google Scholar 

  31. Glasser, S. R., Lampelo, S., Munir, M. I., and Julian, J., Expression of desmin, laminin and fibronectin during in situdifferentiation (decidualization) of rat uterine stromal cells. Differentiation, 35:132 (1987).

    Article  PubMed  CAS  Google Scholar 

  32. Gurchot, C., The trophoblast theory of cancer (John Beard, 1857–1924) revisited, Oncology, 31:310 (1969).

    Article  Google Scholar 

  33. Iwakura, Y. and Nozaki, M., Effect of tunicamycin on preimplantaton mouse embryos: prevention of molecular differentiation during blastocyst formation, Dev. Biol., 112:124 (1985).

    Article  Google Scholar 

  34. Kennedy, T., The role of prostaglandins in endometrial vascular changes at implantation, In: Cellular and Molecular Aspects of Implantation, S. R. Glasser and R. W. Bullock, (eds.), New York, Plenum Press (1981), pp. 349.

    Chapter  Google Scholar 

  35. Lambadarios, C., Hastings, C., Abo-Darub, J., and Cooke, I. D., Steroid effects on human endometrial glycoprotein synthesis, J. Reprod. Fertil., 46:383 (1976).

    Article  PubMed  CAS  Google Scholar 

  36. Leivo, I., Vaheri, A., Timpl, R., and Wartiovaara, J., Appearance and distribution of collagens and laminins in the early mouse embryo, Dev. Biol., 76:100 (1980).

    Article  PubMed  CAS  Google Scholar 

  37. Nelson, J. D., Jato-Rodriguez, J. J., and Mookerjea, S., Effect of ovarian hormones on glycosyltransferase activities in the endometrium of ovariectomized rats, Arch. Biochem. Biophys., 169:181 (1975).

    CAS  Google Scholar 

  38. Maharajan, P. and Maharajan, V., Behavioral pattern of tumour cells in mouse uterus, Gynecol. Obstet. Inves., 21:32 (1986).

    Article  CAS  Google Scholar 

  39. Maharajan, P., Rosato, F., and Maharajan, V., Response of mouse embryos to tumour extract treatment, Gynecol. Obstet. Invest., 23:208 (1987).

    Article  PubMed  CAS  Google Scholar 

  40. Maharajan, P., Rosato, F., Mirabella, N., Pelayalli, G., and Maharajan, V., Influence of mouse uterus on the metastatic patterns of tumour cells, Canc. Lett., 43:33 (1988).

    Article  CAS  Google Scholar 

  41. Munakata, H., Isemura, M., Aikawa, J., Kodama, C., and Yosizawa, Z., Changes of glycosaminoglycan composition of uterine myometrium of rabbit induced by female sex steroids, Tohoku. J. Exp. Med., 147:77 (1985).

    Article  PubMed  CAS  Google Scholar 

  42. Munakata, H., Isemura, M., and Yosizawa, Z., Effects of female hormones on the activity of 3’-phosphoadenylylsulphate: desulphated heparan sulfate sulphotransferase in the endometrium of rabbit uterus, Int. J. Biochem., 17:1077 (1985).

    Article  PubMed  CAS  Google Scholar 

  43. Munakata, H., Isemura, M., and Yosizawa, Z., Enzymatic sulfation of exogenous high molecular weight glycopeptides by microsomal fraction of the rabbit uterine endometrium, J. Biol. Chem., 260: 6851 (1985).

    PubMed  CAS  Google Scholar 

  44. Muramatsu, T., Developmentally regulated expression of cell surface carbohydrates during mouse embryogenesis, J. Cell. Biochem., 36:1 (1988).

    Article  PubMed  CAS  Google Scholar 

  45. Morris, J. E., Potter, S. W., and Gaza-Bulesco, G., Estradiol induces an accumulation of free heparan sulfate glycosaminoglycan chains in uterine epithelium, Endocrinology, 122:242 (1988).

    Article  PubMed  CAS  Google Scholar 

  46. Morris, J. E., Potter, S. W., and Gaza-Bulesco, G., Estradiol-stimulated turnover of heparan sulfate proteoglycan in mouse uterine epithelium, J. Biol. Chem., 263:4712 (1988).

    PubMed  CAS  Google Scholar 

  47. Olden, K., Parent, J. B., and White, S. L., Carbohydrate moieties of glycoproteins, a reevaluation of their function, Biochim. Biophys. Acta, 650:209 (1982).

    Article  CAS  Google Scholar 

  48. Nose, A. and Takeichi, M., A novel cadherin adhesion molecule: Its expression patterns associated with implantation and organogenesis of mouse embryos, J. Cell Biol., 103:2649 (1986).

    Article  PubMed  CAS  Google Scholar 

  49. Pinsker, M. C. and Mintz, B., Change in cell-surface glycoproteins of mouse embryos before implantation, Proc. Natl. Acad. Sci. USA, 70:1645 (1973).

    Article  PubMed  CAS  Google Scholar 

  50. Psychoyos, A., Hormonal control of ovum implantation, Vit. Horm., 31:201 (1973).

    Article  CAS  Google Scholar 

  51. Quarmby V.E. and Korach KS., The influence of 17-ß-estradiol on patterns of cell division in the uterus, Endocrinology, 114:694 (1984).

    Article  PubMed  CAS  Google Scholar 

  52. Schlafke, S. and Enders, A. C., Cellular basis of interaction between trophoblast and uterus at implantation, Biol. Reprod., 12:41 (1975).

    Article  PubMed  CAS  Google Scholar 

  53. Schleich, A. B., Frick, M., and Mayer, A., Patterns of invasive growth in vitro.Human decidua graviditatis confronted with established human cell lines and primary human explants, J. Natl. Canc. Inst., 56:221 (1976).

    CAS  Google Scholar 

  54. Schlesinger, M., Uterus of rodents as site for manifestation of transplantation immunity against transplantable tumors, J. Natl. Canc. Inst., 28:927 (1962).

    CAS  Google Scholar 

  55. Sherman, M. I. and Atienza-Samols, S. B.In vitrostudies on the adhesiveness of mouse blastocysts, In: Human Fertilization, H. Ludwig and P. Taiber, (eds.), PGS, Boston (1978), pp. 179.

    Google Scholar 

  56. Sherman, M. I., Gay, R.Gay, S., and Miller, E. J., Association of collagen with preimplantation mouse embryos, Dev. Biol., 74:270 (1980).

    Article  Google Scholar 

  57. Sherman, M. I. and Salomon, D. S., The relationship between the early mouse embryo and its environment, In: Developmental Biology of Reproduction, C. L. Markert and J. Papaconstantinou, (eds.), New York, Academic Press (1975) pp. 277.

    Google Scholar 

  58. Sherman, M. I. and Wudl, L. R., The implanting mouse blastocyst, In: The Cell Surface of Animal Development, G. Poste and F. R. Nicolson, (eds.), North Holland Publ., Amsterdam (1976), p. 81.

    Google Scholar 

  59. Simons, K. and Fuller, S. D., Cell surface polarity in epithelia, Ann. Rev. Cell Biol., 1:243 (1985).

    Article  PubMed  CAS  Google Scholar 

  60. Surani, M. A. H., Glycoprotein synthesis and inhibition of protein glycosylation by tunicamycin in preimplantation embryos: influence on compaction and trophoblast adhesion, Cell, 18:217 (1979).

    Article  PubMed  CAS  Google Scholar 

  61. Sutherland, A. E., Calarco, P. G., and Damsky, C. H., Expression and function of cell surface extracellular matrix receptors in mouse blastocyst attachment and outgrowth, J. Cell Biol., 106:1331 (1988).

    Article  PubMed  CAS  Google Scholar 

  62. Svalander, P. C., Odin, P., Nilsson, B. O., and Obrink, B., Trophectoderm surface expression of the cell adhesion molecule cell-CAM 105 on rat blastocysts, Develop., 100:653 (1987).

    CAS  Google Scholar 

  63. Tang, J. P., Julian, J.Glasser, S. R., and Carson, D. D., Heparan sulfate proteoglycan synthesis and metabolism by mouse uterine epithelial cells cultured in vitro, J. Biol. Chem., 262:12832 (1987).

    PubMed  CAS  Google Scholar 

  64. Teng, C. T., Pentecost, B. T., Chen, Y. H., Newbold, R. R., Eddy, E. M., and McLachlan, J. A., Lactotransferrin gene expression in the mouse uterus and mammary gland, Endocrinology, 124:992 (1989).

    Article  PubMed  CAS  Google Scholar 

  65. Vestweber, D., Gossler, A., Boller, K., and Kemler, R., Expression and distribution of cell adhesion molecule uvomorulin in preimplantation embryos, Dev. Biol., 124:451 (1987).

    Article  PubMed  CAS  Google Scholar 

  66. Wewer, V. M., Damjanov, A., Weiss, J., Liotta, L. A., and Damjanov, I., Mouse endometrial stromal cells produce basement membrane components, Differentiation, 32:49 (1986).

    Article  PubMed  CAS  Google Scholar 

  67. Wu, T. C., Wan, Y. J., Chung, A. E., and Damjanov, I.Immunohistochemical localization of entactin and laminin in mouse embryos and fetuses, Dev. Biol., 100:496 (1983).

    Article  PubMed  CAS  Google Scholar 

  68. Duff, A. and Carson, D.D., Lactosaminoglycan assembly, cell surface expression, and release by mouse uterine epithelial cells, J. Biol. Chem., 265:430 (1990).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, 77030, USA

    D. D. Carson, N. Raboudi & A. L. Jacobs

Authors
  1. D. D. Carson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. Raboudi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. L. Jacobs
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Wichita State University, Wichita, Kansas, USA

    Lynn A. Lavia

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Carson, D.D., Raboudi, N., Jacobs, A.L. (1991). Glycoprotein Expression and Function in Embryo-Uterine Interactions. In: Lavia, L.A. (eds) Cellular Signals Controlling Uterine Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3724-3_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3724-3_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6657-7

  • Online ISBN: 978-1-4615-3724-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation