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The Origin and Role of Cytokines Determining Success and Failure in the Post-Implantation Period

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Cellular Signals Controlling Uterine Function

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Abstract

The success of mammalian pregnancy is believed to depend on a co-ordinated sequence of synchronized events in the uterus and in the embryo. For example, loss of appropriate phasing between developmental events in the pre-implantation embryo and uterus may account for implantation failure of in vitro fertilized oocytes in the rat (1) and with in vivo embryo transfer in domestic animals (2). One may view the normal co-ordination of events simply as a manifestation of the independent execution of a genetically defined program which achieves its synchrony when the “seed” and the “soil” belong to the same species. However, there is increasing evidence of an interplay between the embryo and the uterus whereby signals pass from one to the other. The success of pregnancy may then depend upon successful co-operation.

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  1. Department of Medicine, McMaster University, Hamilton, Ontario, Canada

    David A. Clark

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  1. David A. Clark
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  1. Wichita State University, Wichita, Kansas, USA

    Lynn A. Lavia

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Clark, D.A. (1991). The Origin and Role of Cytokines Determining Success and Failure in the Post-Implantation Period. In: Lavia, L.A. (eds) Cellular Signals Controlling Uterine Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3724-3_12

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  • DOI: https://doi.org/10.1007/978-1-4615-3724-3_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6657-7

  • Online ISBN: 978-1-4615-3724-3

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