Abstract
A perfect medication is one which is effective 100% of the time, completely relieves the symptoms of the disorder being treated, and causes no side effects. Unfortunately, no such medications exist. Many medications have the potential for affecting alertness, behavior, and cognitive function. This is of particular importance in children, since they will be receiving this medication in the critical years during which development and learning are a key part of the maturational process. The negative impact of medication may be overt or subtle. The more clear-cut disturbances in development and behavior generally take place when the medications are given beyond the usual therapeutic levels, and they are often associated with more easily documentable physiological disturbances. It is more difficult to detect the subtle forms of disturbances which may take place when the medications are given in therapeutic amounts and do not lead to easily defined physical symptoms. The clinician must be alert to the possibility of subtle disturbances. The process of ongoing follow-up must include detailed questions about changes in a child’s behavioral patterns as well as in deviations in developmental and learning progress. Admittedly, it is often difficult to differentiate the effects medication from those which are due to the medical disorder itself or the psychological need to adapt to a chronic illness.of
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Bourgeois, B. F. D., Prensky, A. L., Palkes, H. S., Talent, B. K., and Busch, S. G., 1983, Intelligence in epilepsy: A prospective study in children, Ann. Neurol. 14:438–444.
Callaghan, N., Garrett, A., and Goggin, T., 1988, Withdrawal of anticonvulsant drugs in patients free of seizures for two years. A prospective study, N. Engl. J. Med. 318:942–946.
Committee on Drugs, American Academy of Pediatrics, 1985, Behavioral and cognitive effects of anticonvulsant therapy, Pediatrics 76:644–647.
Denckla, M. B., Bemporad, J. R., and MacKay, M. C., 1976, Tics following methylphenidate administration: A report of 20 cases, J. Am. Med. Assoc. 235:1349–1351.
DiTraglia, J., 1987, School performance and theophylline (Letter to the Editor), Pediatrics 80:122.
Ellenberg, J. H., Hirtz, D. G., and Nelson, K. B., 1986, Do seizures in children cause intellectual deterioration? N. Engl. J. Med. 314: 1085–1088.
Erenberg, G., Cruse, R. P., and Rothner, A. D., 1985, Gilles de la Tourette’s syndrome: Effects of stimulant drugs, Neurology 35:1346–1348.
Erenberg, G., Cruse, R. P., and Rothner, A. D., 1986, Tourette syndrome: An analysis of 200 pediatric and adolescent cases, Cleveland Clin. Q. 53: 127–131.
Erenberg, G., Cruse, R. P., and Rothner, A. D., 1987, The natural history of Tourette syndrome, Ann. Neurol. 22:383–385.
FDA Drug Bulletin, November 1988, Theophylline and school performance, FDA Drug Bulletin pp. 32–33.
Giordani, B., Sackellares, J. C., Miller, S., Berent, S., Sutula, T., Seidenberg, M., Boll, T. J., O’Leary, D., and Dreifuss, F. E., 1983, Improvement in neuropsychological performance in patients with refractory seizures after intensive diagnostic and therapeutic intervention, Neurology 33:489–493.
Golden, G. S., 1988, The relationship between stimulant medication and tics, Pediatr. Ann. 17:405–408.
Herranz, J. L., Armijo, J. A., and Arteaga, R., 1988, Clinical side effects of phenobarbital, primidone, phenytoin, carbamazepine, and valproate during monotherapy in children, Epilepsia 29:794–804.
Holmes, G. L., 1988, Do seizures cause brain damage? Int. Pediatr. 3:158–164.
Leckman, J. F., Detlor, J., Harcherik, D. F., Ort, S., Shaywitz, B. A., and Cohen, D.J., 1985, Short-and long-term treatment of Tourette’s syndrome with c1onidine: A clinical perspective, Neurology 35:343–351.
Lesser, R. P., Luders, H., Wyllie, E., Dinner, D. S., and Morris, H. H., 1986, Mental deterioration in epilepsy, Epilepsia 27(Suppl. 2):S105–S123.
Lowe, T. L., Cohen, D. J., Detler, J., Kremenitzer, M. W., and Shaywitz, B. A., 1982, Stimulant medications precipitate Tourette’s syndrome, J. Am. Med. Assoc. 247: 1729–1731.
Pauls, D. L., and Leckman, J. F., 1986, The inheritance of Gilles de la Tourette’s syndrome and associated behaviors, N. Engl. J. Med. 315:993–997.
Pliszka, S. R., 1987, Tricyclic antidepressants in the treatment of children with attention deficit disorder: Review article, J. Am. Acad. Child Adol. Psychiatr. 26:127–132.
Price, R. A., Leckman, J. F., Pauls, D. L., Cohen, D. J., and Kidd, K. K., 1986, Gilles de la Tourette’s syndrome: Tics and central nervous system stimulants in twins and nontwins, Neurology 36:232–237.
Rappaport, J., Fenton, T., and Twarog, F., 1987, School performance and theophylline (Letter to the Editor), Pediatrics 80: 125–126.
Rachelefsky, G. S., Wo, J., Adelson, J., Mickey, M. R., Spector, S. L., Katz, R. M., Siegel, S. C., and Rohr, A. S., 1986, Behavior abnormalities and poor school performance due to oral theophylline use, Pediatrics 78: 1133–1138.
Schriver, R. C., 1987, School performance and theophylline (Letter to the Editor), Pediatrics 80: 123.
Shapiro, A. K., Shapiro, E., 1981, Do stimulants provoke, cause, or exacerbate tics and Tourette’s syndrome? Compr. Psychiatry 22:265–273.
Trimble, M. R., 1987, Anticonvulsant drugs and cognitive function: A review of the literature, Epilepsia 28(Suppl. 3):S37–S45.
Vining, E. P. G., 1987, Cognitive dysfunction associated with antiepileptic drug therapy, Epilepsia 28(Suppl. 2):S18–S22.
Vining, E. P. G., Shinnar, S. S., Mellits, D., Silverton, S., and Brandt, J., 1986, Discontinuing antiepileptic drugs improves intellectual function, Epilepsia 27:639.
Weinberger, M., Lindgren, S., Bender, B., Lerner, J. A., and Szefler, S., 1987a, Effects of theophylline on learning and behavior: Reason for concern or concern without reason? J. Pediatr. 111:471–474.
Weinberger, M., Lindgren, S., and Joad, J., 1987b, School performance and theophylline (Letter to the Editor), Pediatrics 80: 124.
Wolf, S. M., and Forsythe, A. 1978, Behavioral disturbance, phenobarbital, and febrile seizures, Pediatrics 61:728–731.
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Erenberg, G. (1991). Neuropharmacological Therapies. In: Gottlieb, M.I., Williams, J.E. (eds) Developmental-Behavioral Disorders. Critical Issues in Developmental and Behavioral Pediatrics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3714-4_16
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DOI: https://doi.org/10.1007/978-1-4615-3714-4_16
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