Skip to main content

Neuropharmacological Therapies

Potential Neurodevelopmental and Behavioral Complications

  • Chapter
Developmental-Behavioral Disorders
  • 86 Accesses

Abstract

A perfect medication is one which is effective 100% of the time, completely relieves the symptoms of the disorder being treated, and causes no side effects. Unfortunately, no such medications exist. Many medications have the potential for affecting alertness, behavior, and cognitive function. This is of particular importance in children, since they will be receiving this medication in the critical years during which development and learning are a key part of the maturational process. The negative impact of medication may be overt or subtle. The more clear-cut disturbances in development and behavior generally take place when the medications are given beyond the usual therapeutic levels, and they are often associated with more easily documentable physiological disturbances. It is more difficult to detect the subtle forms of disturbances which may take place when the medications are given in therapeutic amounts and do not lead to easily defined physical symptoms. The clinician must be alert to the possibility of subtle disturbances. The process of ongoing follow-up must include detailed questions about changes in a child’s behavioral patterns as well as in deviations in developmental and learning progress. Admittedly, it is often difficult to differentiate the effects medication from those which are due to the medical disorder itself or the psychological need to adapt to a chronic illness.of

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bourgeois, B. F. D., Prensky, A. L., Palkes, H. S., Talent, B. K., and Busch, S. G., 1983, Intelligence in epilepsy: A prospective study in children, Ann. Neurol. 14:438–444.

    Google Scholar 

  • Callaghan, N., Garrett, A., and Goggin, T., 1988, Withdrawal of anticonvulsant drugs in patients free of seizures for two years. A prospective study, N. Engl. J. Med. 318:942–946.

    Google Scholar 

  • Committee on Drugs, American Academy of Pediatrics, 1985, Behavioral and cognitive effects of anticonvulsant therapy, Pediatrics 76:644–647.

    Google Scholar 

  • Denckla, M. B., Bemporad, J. R., and MacKay, M. C., 1976, Tics following methylphenidate administration: A report of 20 cases, J. Am. Med. Assoc. 235:1349–1351.

    Google Scholar 

  • DiTraglia, J., 1987, School performance and theophylline (Letter to the Editor), Pediatrics 80:122.

    Google Scholar 

  • Ellenberg, J. H., Hirtz, D. G., and Nelson, K. B., 1986, Do seizures in children cause intellectual deterioration? N. Engl. J. Med. 314: 1085–1088.

    Google Scholar 

  • Erenberg, G., Cruse, R. P., and Rothner, A. D., 1985, Gilles de la Tourette’s syndrome: Effects of stimulant drugs, Neurology 35:1346–1348.

    Google Scholar 

  • Erenberg, G., Cruse, R. P., and Rothner, A. D., 1986, Tourette syndrome: An analysis of 200 pediatric and adolescent cases, Cleveland Clin. Q. 53: 127–131.

    Google Scholar 

  • Erenberg, G., Cruse, R. P., and Rothner, A. D., 1987, The natural history of Tourette syndrome, Ann. Neurol. 22:383–385.

    Google Scholar 

  • FDA Drug Bulletin, November 1988, Theophylline and school performance, FDA Drug Bulletin pp. 32–33.

    Google Scholar 

  • Giordani, B., Sackellares, J. C., Miller, S., Berent, S., Sutula, T., Seidenberg, M., Boll, T. J., O’Leary, D., and Dreifuss, F. E., 1983, Improvement in neuropsychological performance in patients with refractory seizures after intensive diagnostic and therapeutic intervention, Neurology 33:489–493.

    Google Scholar 

  • Golden, G. S., 1988, The relationship between stimulant medication and tics, Pediatr. Ann. 17:405–408.

    Google Scholar 

  • Herranz, J. L., Armijo, J. A., and Arteaga, R., 1988, Clinical side effects of phenobarbital, primidone, phenytoin, carbamazepine, and valproate during monotherapy in children, Epilepsia 29:794–804.

    Google Scholar 

  • Holmes, G. L., 1988, Do seizures cause brain damage? Int. Pediatr. 3:158–164.

    Google Scholar 

  • Leckman, J. F., Detlor, J., Harcherik, D. F., Ort, S., Shaywitz, B. A., and Cohen, D.J., 1985, Short-and long-term treatment of Tourette’s syndrome with c1onidine: A clinical perspective, Neurology 35:343–351.

    Google Scholar 

  • Lesser, R. P., Luders, H., Wyllie, E., Dinner, D. S., and Morris, H. H., 1986, Mental deterioration in epilepsy, Epilepsia 27(Suppl. 2):S105–S123.

    Google Scholar 

  • Lowe, T. L., Cohen, D. J., Detler, J., Kremenitzer, M. W., and Shaywitz, B. A., 1982, Stimulant medications precipitate Tourette’s syndrome, J. Am. Med. Assoc. 247: 1729–1731.

    Google Scholar 

  • Pauls, D. L., and Leckman, J. F., 1986, The inheritance of Gilles de la Tourette’s syndrome and associated behaviors, N. Engl. J. Med. 315:993–997.

    Google Scholar 

  • Pliszka, S. R., 1987, Tricyclic antidepressants in the treatment of children with attention deficit disorder: Review article, J. Am. Acad. Child Adol. Psychiatr. 26:127–132.

    Google Scholar 

  • Price, R. A., Leckman, J. F., Pauls, D. L., Cohen, D. J., and Kidd, K. K., 1986, Gilles de la Tourette’s syndrome: Tics and central nervous system stimulants in twins and nontwins, Neurology 36:232–237.

    Google Scholar 

  • Rappaport, J., Fenton, T., and Twarog, F., 1987, School performance and theophylline (Letter to the Editor), Pediatrics 80: 125–126.

    Google Scholar 

  • Rachelefsky, G. S., Wo, J., Adelson, J., Mickey, M. R., Spector, S. L., Katz, R. M., Siegel, S. C., and Rohr, A. S., 1986, Behavior abnormalities and poor school performance due to oral theophylline use, Pediatrics 78: 1133–1138.

    Google Scholar 

  • Schriver, R. C., 1987, School performance and theophylline (Letter to the Editor), Pediatrics 80: 123.

    Google Scholar 

  • Shapiro, A. K., Shapiro, E., 1981, Do stimulants provoke, cause, or exacerbate tics and Tourette’s syndrome? Compr. Psychiatry 22:265–273.

    Google Scholar 

  • Trimble, M. R., 1987, Anticonvulsant drugs and cognitive function: A review of the literature, Epilepsia 28(Suppl. 3):S37–S45.

    Google Scholar 

  • Vining, E. P. G., 1987, Cognitive dysfunction associated with antiepileptic drug therapy, Epilepsia 28(Suppl. 2):S18–S22.

    Google Scholar 

  • Vining, E. P. G., Shinnar, S. S., Mellits, D., Silverton, S., and Brandt, J., 1986, Discontinuing antiepileptic drugs improves intellectual function, Epilepsia 27:639.

    Google Scholar 

  • Weinberger, M., Lindgren, S., Bender, B., Lerner, J. A., and Szefler, S., 1987a, Effects of theophylline on learning and behavior: Reason for concern or concern without reason? J. Pediatr. 111:471–474.

    Google Scholar 

  • Weinberger, M., Lindgren, S., and Joad, J., 1987b, School performance and theophylline (Letter to the Editor), Pediatrics 80: 124.

    Google Scholar 

  • Wolf, S. M., and Forsythe, A. 1978, Behavioral disturbance, phenobarbital, and febrile seizures, Pediatrics 61:728–731.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Erenberg, G. (1991). Neuropharmacological Therapies. In: Gottlieb, M.I., Williams, J.E. (eds) Developmental-Behavioral Disorders. Critical Issues in Developmental and Behavioral Pediatrics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3714-4_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3714-4_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6652-2

  • Online ISBN: 978-1-4615-3714-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics