Abstract
Mesenchymal-epithelial interaction is an integral part of embryonic development (1,2). This interaction continues throughout adult life and is responsible for maintaining the differentiative functions of a variety of mature organs (3). Classical approaches demonstrating the inductive activity of mesenchymes on epithelial growth and phenotypic expression have used surgically and enzymatically dissected cellular components (e.g., mesenchyme or epithelium) and recombined them either homo- or heterotypically (4-6). The advantages of this approach are that mesenchymal-epithelial interactions can be studied in purely separated cellular compartments and that the resultant recombinants are capable of developing fully into functional mature organs or body parts.
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Chung, L.W.K. et al. (1991). Fibroblast-Mediated Human Epithelial Tumor Growth and Hormonal Responsiveness in Vivo. In: Karr, J.P., Coffey, D.S., Smith, R.G., Tindall, D.J. (eds) Molecular and Cellular Biology of Prostate Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3704-5_8
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DOI: https://doi.org/10.1007/978-1-4615-3704-5_8
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