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Molecular and Cellular Biology of Prostate Cancer pp 81–90Cite as

Fibroblast Growth Factor: Implications in the Etiology of Benign Prostatic Hyperplasia

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Abstract

The development of benign prostatic hyperplasia (BPH) is considered an inescapable phenomena for the aging male. Ninety percent of men will develop histologic evidence of BPH by the age of 80 (1). Bladder outlet obstruction is the major consequence associated with BPH. It has been estimated that 20- 25% of all men over the age of 50 will require a prostatectomy for relief of bladder outlet obstruction (2). Approximately 350,000 surgical procedures are performed each year in the United States for BPH, resulting in an overall medical cost that exceeds 1 billion dollars annually (3). These statistics emphasize the need for new approaches to the study of BPH, for despite many years of study, the etiology of the disease has not been resolved.

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Authors and Affiliations

  1. Departments of Urology and Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA, 53226

    Michael T. Story

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  1. Michael T. Story
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Editor information

Editors and Affiliations

  1. Office of Scientific Administration, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA

    James P. Karr Ph.D. (Chief) (Chief)

  2. The Johns Hopkins Hospital and University, Marburg Building, 600 North Wolfe Street, Baltimore, MD, 21205, USA

    Donald S. Coffey Ph.D. (Professor of Urology, Oncology and Pharmacology) (Professor of Urology, Oncology and Pharmacology)

  3. Department of Growth Biochemistry and Physiology, Merck, Sharpe and Dohme Research Lab, 126 East Lincoln Avenue, Rahway, NJ, 07065, USA

    Roy G. Smith Ph.D.

  4. Mayo Clinic, Guggenheim-4 200 First Street, SW, Rochester, MN, 55905, USA

    Donald J. Tindall Ph.D. (Professor of Urologic Research) (Professor of Urologic Research)

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© 1991 Springer Science+Business Media New York

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Story, M.T. (1991). Fibroblast Growth Factor: Implications in the Etiology of Benign Prostatic Hyperplasia. In: Karr, J.P., Coffey, D.S., Smith, R.G., Tindall, D.J. (eds) Molecular and Cellular Biology of Prostate Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3704-5_7

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  • DOI: https://doi.org/10.1007/978-1-4615-3704-5_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6647-8

  • Online ISBN: 978-1-4615-3704-5

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