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Studies of the Endocrine and Paracrine Effect of Tumor Produced Factors in Human Genitourinary Cancers

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Book cover Molecular and Cellular Biology of Prostate Cancer

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Abstract

Both prostate as well as kidney cancer are common malignancies in the United States. It is projected that in 1990, prostate carcinoma will be the most common cancer in men and will result in 20,000 deaths. Although hormonal manipulation is the mainstay of therapy of patients with advanced prostate carcinoma, there is no currently available effective therapy for patients with this malignancy. Over 20,000 patients develop kidney cancer per year in the United States, and there are over 9,500 deaths from this cancer. Recent studies have reported approximately a 95%, 5 year survival for patients with Stage T1, No renal cell carcinoma and a 92% survival for patients with Stage T2, No disease (1,2). While the five year survival for patients with N + (local nodal involvement) renal cell carcinoma is 20% (3,4), patients with distant renal cell carcinoma metastases have only a 20% five year survival (5).

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References

  1. Bassil, B., Dosoretz, D.E., and Prout, G.R. Validation of the tumor, nodes and metastasis classification of renal cell carcinoma. J Urol 134:450, 1985.

    PubMed  CAS  Google Scholar 

  2. Selli, C., Hinshaw, W.M., Woodard, B.H., Paulson, D.F. Stratification of risk factors in renal cell carcinoma. Cancer 52:899, 1983.

    Article  PubMed  CAS  Google Scholar 

  3. DeKernion, J.B. Lymphadenectomy for renal cell carcinoma. Urol. Clin. NA 7:697, 1980.

    CAS  Google Scholar 

  4. Neidhart, J.A. Interferon therapy for the treatment of renal cancer. Cancer 57:1696, 1986.

    Article  PubMed  CAS  Google Scholar 

  5. Linehan, W.M., Shipley, W. and Longo, D.: Cancer of the kidney and ureter, in DeVita, V.T., Hellman, S. and Rosenberg, S.A. (eds.): Principles and Practices of Oncology, Philadelphia, J.B. Lippincott, 979–1007, 1989.

    Google Scholar 

  6. Franck, J.L., Bouteiller, G. Fauchier, C., Sarramon, J.P. and Arlet, J. Profil biologique et histologique d’osteomalacie dans I’osteose condensate prostatique. Revue Du Rhumatisme, 49:81, 1982.

    CAS  Google Scholar 

  7. Raskin, P., McClain, C.J. and Medsger, T. A. Hypocalcemia associated with metastatic bone disease. Arch. Intern. Med. 132:539, 1973.

    Article  PubMed  CAS  Google Scholar 

  8. Ludwig, G.D. Hypocalcemia and hypophosphatemia accompanying osteoblastic osseous metastases: studies of calcium and phosphate metabolism and parathyroid function. Ann. Intern. Med. 56:676, 1962.

    Google Scholar 

  9. Mahadevia, P.S., Ramaswamy, A., Greenwald, E.S., Wollner, D.I., and Markham, D. Hypercalcemia in prostate carcinoma. Arch. Intern. Med. 143:1339, 1983.

    Article  PubMed  CAS  Google Scholar 

  10. Olsson, A.M. and Jonsson, G. Advanced cancer of the prostate combined with hypercalcaemia. Scand J. Urol. Nephrol. 11:293, 1977.

    Article  PubMed  CAS  Google Scholar 

  11. Lyles, K.W., Berry, W.R., Haussler, M., Harrelson, J.M. and Drezner, M.D. Hypophosphatemic osteomalacia: association with prostatic carcinoma. Ann Intern Med 93:275, 1980.

    PubMed  CAS  Google Scholar 

  12. Delbarre, F., Chozlan, R. and Amor, B. Metastases osseuses avec osteomalacie au cours du cancer de la prostate. La Nouvelle Presse Medicale 4:17, 1975.

    Google Scholar 

  13. Randall R.L. and Lierman, D.S. Hypocalcemia and hypophosphatemia accompanying osteoblastic metastases. J. Clin. Metabol. 24:1331, 1964.

    Article  Google Scholar 

  14. Ryckewaert, A., Seze, de S., Lanham, C., Hioco, D. and Moniglia, B. Troubles du metabolisme phosphocalcique au cours des cancers secondaires des os a forme condensante d’origine prosta-tique. Sem. Hosp. Paris 42:1052, 1966.

    Google Scholar 

  15. Smallridge, R.C., Wray, H.L. and Schaaf, M. Hypocalcemia with osteoblastic metastases in a patient with prostate carcinoma. Am J Med 71:184, 1981.

    Article  PubMed  CAS  Google Scholar 

  16. Tommaso, C.L. and Tucci, J.R. Metabolic studies in a case of hypocalcemia and osteoblastic metastases. Arch Intern Med 139:238, 1979.

    Article  PubMed  CAS  Google Scholar 

  17. Linehan, W.M., Kish, M.L., Chen, S.L., Andriole, G.L., and Santora, A.C. Human prostate carcinoma causes hypercalcemia in athymic nude mice and produces a factor with parathyroid hormonelike bioactivity. J. Urol. 135:616, 1986.

    PubMed  CAS  Google Scholar 

  18. Charhon, S.A., Chapuy, M.C., Delvin, E.E., Valentin-Opran, A., Edouard, C.M. and Neunier, P. J. Histomorphometric analysis of sclerotic bone metastases from prostatic carcinoma with special reference to osteomalacia. Cancer 51:918, 1983.

    Article  PubMed  CAS  Google Scholar 

  19. Guillard-Cumming, D., Lawson-Matthew, P., Challa, A., Clayton, J., Yates, A.J.P., Percival R., Mundy, K., Russell, R.G. and Kanis, J.A. Abnormal vitamin D metabolism in skeletal neoplasia: relationship to skeletal turnover. Proc. Am. Soc. Bone Min Res 5:A57, 1983.

    Google Scholar 

  20. Graham, S.D., Poulton, S.H., Linder, J., Woodard, B.H., Lyles, D.W. and Paulson, D.F. Establishment of a long term adenocarcinoma of the prostate cell line in the nude mouse. The Prostate 7:369, 1985.

    Article  Google Scholar 

  21. Lyles, L.W., Lobaugh, B., Paulson, D.F. and Drezner, M.D. Heterotransplantation of prostatic cancer from an affected patient creates an auimal model for tumor-induced osteomalacia (T10) in the athymic nude mouse (ANM). Proc Am Soc Bone Min Res 4:533, 1982.

    Google Scholar 

  22. Rodan, S.B., Insogna, K.L., Vignery, W.M., Stewart, A.F., Broadus, A.E., D’Souza, S.M., Bertolini, D.R. Mundy, G.R., and Rodan, G.A. Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells. J Clin Invest 72:1511, 1983.

    Article  PubMed  CAS  Google Scholar 

  23. Tashjian, A.H., Boelkel, E.F., Lloyd, W., Derynck, R., Winkler, M.E., and Levine, L. Actions of growth factor-alpha cause elevation of plasma calcium in mice. J Clin Invest 78:1405, 1986.

    Article  PubMed  CAS  Google Scholar 

  24. Derynck, R., Goeddel, D.V., Ullrich, A., Gutterman, J.U., Williams, R.D., Bringman, T.S., Berger, W.H. Synthesis of messenger RNA’s for transforming growth factors alpha and beta and the epidermal growth factor alpha and beta and the epidermal growth factor receptor by human tumors. Cancer Res 47:707, 1987.

    PubMed  CAS  Google Scholar 

  25. Chisholm, G.D. Nephrogenic ridge tumors and their syndromes. Ann NY Acad Sci 230:403, 1974.

    Article  PubMed  CAS  Google Scholar 

  26. Strewler, G.J., Williams, R.D. and Nissenson, R.A. Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors. J Clin Invest 71:769, 1983.

    Article  PubMed  CAS  Google Scholar 

  27. Gomella, L.G., Sargent, E.R., Wade, T.P., Anglard, P., Linehan, W.M., and Kasis, A. Expression of transforming growth factor alpha in normal adult kidney and enhanced expression of transformin growth factor alpha and beta in renal cell carcinoma. (In Press: Cancer Res).

    Google Scholar 

  28. Gomella, L.G., Sargent, E.R., Linehan, W.M., and Kasid, A.: Transforming growth factor-beta inhibits the growth of renal cell carcinoma in vitro. J Urol 141:1240, 1989.

    PubMed  CAS  Google Scholar 

  29. Linehan, W.M., Robertson, C., Anglard, L., Gomella, L.G., Sargent, E.R.,, Wade, T., Kasid, A.: Clinical Perspective: Renal Cell Carcinoma-Potential Biologic and Molecular Approaches to Diagnosis and Therapy. Cancer Cells 7, Cold Spring Harbor Lab, 59, 1989.

    Google Scholar 

  30. Kasid, A., Bell, G.I., Director, E.P. Effects of TGF-beta on human Lymphokine activated killer cell precursors: autocrine inhibition of cellular proliferation and differentiation to immune killer cells. J Immunol 141:690, 1988.

    PubMed  CAS  Google Scholar 

  31. Mule, J.J., Schwarz, S.L., Roberts, A.B., Sport, M.B., and Rosenberg, S.A. Transforming growth factor-beta inhibits the in vitro generation of lymphokine-activated killer cells and cytotoxic T cells. Cancer Immunol Immunother 26:95, 1988.

    PubMed  CAS  Google Scholar 

  32. Kehrl, J.H., Wakefield, L.M., Roberts, Jakowlew, S., Alvarez, M., Derynck, R., Sporn, M., and Fauci, A.S. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med 163:1037, 1986.

    Article  PubMed  CAS  Google Scholar 

  33. Stein, C.A., LaRocca, R.V., Thomas, R., McAtee, N., and Myers, C.E. Suramin: an anticancer drug with a unique mechanism of action. J Clin Oncol 7:499–508, 1989.

    PubMed  CAS  Google Scholar 

  34. Mitsuya, M., Popovic, M., Yarchoan, R., Matusshita, S., Gallo, R.C., Broder, S. Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV III. Science 226:172–174, 1984.

    Article  PubMed  CAS  Google Scholar 

  35. Garrett, J., Coughlin, S., Niman, H., Tremble, P.M., Giels, G.M., Williams, L.T. Blockade of autocrine stimulation in simian sarcoma virus transformed cells reverses down-regulation of plateletderived growth factor receptors. Proc. Natl. Acad. Sci. USA 81:7466–7470, 1984.

    Article  PubMed  CAS  Google Scholar 

  36. Betsholtz, C., Johnsson A., Heldin, C., Westermark, B. Efficient reversion of simian sarcoma virustransformation and inhibition of growth factor-induced mitogenesis by suramin. Proc. Natl. Acad. Sci. USA 83:6440–6444, 1986.

    Article  PubMed  CAS  Google Scholar 

  37. Coffey, R., Leof, E., Shipley, G., Moses, H.L. Suramin inhibition of growth factor receptor binding and mitogenicity in AKR-2B cells. J. Cell Phys. 132:143, 1987.

    Article  CAS  Google Scholar 

  38. Coffey, R., Leof, E., Shipley, G., et al. Suramin inhibition of growth factor receptor binding and mitogenicity in AKR-2B cells. J. Cell Phys. 132:143–148, 1987.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Surgery Branch, Division of Cancer Treatment, Bethesda, MD, 20892, USA

    W. Marston Linehan, McClellan T. Walther, Eric R. Sargent, Leonard G. Gomella, Cary N. Robertson, P. Anglard, T. P. Wade, Gary H. Weiss, M. W. Ewing & Sue Liu

  2. Medicine Branch, Division of Cancer, National Cancer Institute, Bethesda, MD, 20892, USA

    Renato V. LaRocca & C. E. Myers

Authors
  1. W. Marston Linehan
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  2. McClellan T. Walther
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  3. Eric R. Sargent
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  4. Leonard G. Gomella
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  5. Cary N. Robertson
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  6. P. Anglard
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  7. T. P. Wade
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  8. Gary H. Weiss
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  9. M. W. Ewing
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  10. Sue Liu
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  11. Renato V. LaRocca
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  12. C. E. Myers
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Editor information

Editors and Affiliations

  1. Office of Scientific Administration, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA

    James P. Karr Ph.D. (Chief) (Chief)

  2. The Johns Hopkins Hospital and University, Marburg Building, 600 North Wolfe Street, Baltimore, MD, 21205, USA

    Donald S. Coffey Ph.D. (Professor of Urology, Oncology and Pharmacology) (Professor of Urology, Oncology and Pharmacology)

  3. Department of Growth Biochemistry and Physiology, Merck, Sharpe and Dohme Research Lab, 126 East Lincoln Avenue, Rahway, NJ, 07065, USA

    Roy G. Smith Ph.D.

  4. Mayo Clinic, Guggenheim-4 200 First Street, SW, Rochester, MN, 55905, USA

    Donald J. Tindall Ph.D. (Professor of Urologic Research) (Professor of Urologic Research)

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© 1991 Springer Science+Business Media New York

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Linehan, W.M. et al. (1991). Studies of the Endocrine and Paracrine Effect of Tumor Produced Factors in Human Genitourinary Cancers. In: Karr, J.P., Coffey, D.S., Smith, R.G., Tindall, D.J. (eds) Molecular and Cellular Biology of Prostate Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3704-5_6

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  • DOI: https://doi.org/10.1007/978-1-4615-3704-5_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6647-8

  • Online ISBN: 978-1-4615-3704-5

  • eBook Packages: Springer Book Archive

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