Abstract
Clavulanic acid (CA) has a wide ß-lactamase inhibition spectrum1, especially when combined with a ß-lactam-like amoxycillin or ampicillin. The biological activity of this compound and its derivatives being related to their respective structures, it was deduced from a number of empirical structure-activity relationships that a structure close to that of CA is needed for a potent ß-lactamase inhibitor.
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© 1991 Plenum Press, New York
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Fernández, B., Van Alsenoy, C. (1991). An Ab Initio Study Of Clavulanic Acid And The Relation To Its Chemical Reactivity. In: Jeffrey, G.A., Piniella, J.F. (eds) The Application of Charge Density Research to Chemistry and Drug Design. NATO ASI Series, vol 250. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3700-7_22
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DOI: https://doi.org/10.1007/978-1-4615-3700-7_22
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