Abstract
In the field of research aimed at providing new antitumor drugs we have worked on 5-acyl-6-amino-1,3-dimethyluracils. Among these compounds, 6-amino-5-cinnamoyl-1,3- dimethyluracil (NSC 290115) has revealed interesting antileukaemia activity. The aromatic groups are stabilized in an extended planar structure whose size fits with the base planes of the DNA.
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© 1991 Plenum Press, New York
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Baert, F., Guelzim, A., Warin, V. (1991). Charge Density Distribution of Dimethyl-1,3-Amino-4-Uracil. In: Jeffrey, G.A., Piniella, J.F. (eds) The Application of Charge Density Research to Chemistry and Drug Design. NATO ASI Series, vol 250. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3700-7_14
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DOI: https://doi.org/10.1007/978-1-4615-3700-7_14
Publisher Name: Springer, Boston, MA
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