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Gene Activation and Deactivation during Multistage Hepatocarcinogenesis in the Rat

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Chemical Carcinogenesis 2

Abstract

That the development of most cancer occurs as a result of two or more separate and distinct processes or stages is rapidly becoming more evident as careful studies of carcinogenesis in defined systems take place. In at least five different species of animals, multistage carcinogenic processes have been demonstrated in more than 15 different tissues1. In addition, there is significant epidemiologic evidence that more than a half dozen human cancers exhibit demonstrable stages in their development2. However, there is to date no uniform agreement as to the number and characteristics of distinctive stages or processes in the development of cancer.

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA

    D. Paul

  2. Department of Biological Sciences, SUNY-Buffalo, Buffalo, New York, 14260, USA

    B. Nicholson

  3. McArdle Laboratory for Cancer Research and the Center for Environmental Toxicology, University of Wisconsin-Madison, Madison, Wisconsin, 53706, USA

    H. C. Pitot, M. J. Neveu, J. H. Hully & L. Sargent

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  1. University of Cagliari, Cagliari, Italy

    Amedeo Columbano  & Paolo Pani  & 

  2. University of Sassari, Sassari, Italy

    Francesco Feo  & Rosa Pascale  & 

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Pitot, H.C., Neveu, M.J., Hully, J.H., Sargent, L., Paul, D., Nicholson, B. (1991). Gene Activation and Deactivation during Multistage Hepatocarcinogenesis in the Rat. In: Columbano, A., Feo, F., Pascale, R., Pani, P. (eds) Chemical Carcinogenesis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3694-9_6

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