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S-Adenosylmethionine Content, DNA Methylation and Gene Expression in Regenerating Liver

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Chemical Carcinogenesis 2

Abstract

Cell growth is a fundamental feature of various stages of experimental carcinogenesis. It is a prerequisite for initiation1, and one of the major events of the promotion and progression processes2.

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References

  1. A. Columbano, S. Rajalakshmi, and D. S. R. Sarma, Requirement of cell proliferation for the initiation of liver carcinogenesis as assayed by three different procedures, Cancer Res. 41:2079 (1981).

    PubMed  CAS  Google Scholar 

  2. E. Farber, and D. S. R. Sarma, Hepatocarcinogenesis: A dynamic cellular perspective, Lab. Invest. 56:4 (1987).

    PubMed  CAS  Google Scholar 

  3. H. C. Pitot, L. Harness, and T. Goldsworthy, Biochemical characterization of stages after a single dose of diethylnitrosamine, Nature 271:456 (1978).

    Article  PubMed  CAS  Google Scholar 

  4. H. Shinozuka, M. A. Sells, S. L. Katyal, S. Sell, and B. Lombardi, Effects of a choline-devoid diet on the emergence of γ-glutayltranspeptidase positive foci in the liver of carcinogen-treated rats, Cancer Res. 39:2515 (1979).

    PubMed  CAS  Google Scholar 

  5. C. Laurier, M. Tatematsu, P. M. Rao, S. Rajalakshmi, and D. S. R. Sarma, Promotion by orotic acid of liver carcinogenesis in rats initiated by 1,2-dimethylhydrazine, Cancer Res. 44:2186 (1984).

    PubMed  CAS  Google Scholar 

  6. D. B. Solt, A. Medline, and E. Farber, Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for a sequential analysis of liver carcinogenesis, Am. J. Pathol. 88:595 (1977).

    PubMed  CAS  Google Scholar 

  7. R. Schulte-Hermann, Tumor promotion in the liver, Arch. Toxicol. 57:147 (1985).

    Article  PubMed  CAS  Google Scholar 

  8. E. Farber, Cellular biochemistry of the stepwise development of cancer with chemicals: G. H. A. Clowes Lecture, Cancer Res. 44:5463 (1984).

    PubMed  CAS  Google Scholar 

  9. F. Feo, R. Garcea, L. Daino, and R. Pascale, Mechanism of the inhibition of liver hepatocarcinogenesis promotion by S-adenosyl-L-methionine, in: “Experimental Hepatocarcinogenesis,” M. B. Roberfroid, and V. Préat, eds., Plenum Publ. Corp., New York, (1988).

    Google Scholar 

  10. K. Enomoto, and E. Farber, Kinetics of phenotypic maturation of remodelling of hyperplastic nodules during liver carcinogenesis, Cancer Res. 42:2330 (1982).

    PubMed  CAS  Google Scholar 

  11. M. A. Moore, J. Hacker, and P. Bannasch, Phenotypic instability in focal and nodular lesions induced by a short term system in the rat liver, Carcinogenesis 4:595 (1983).

    Article  PubMed  CAS  Google Scholar 

  12. N. Fausto, and P. R. Shank, Oncogene expression in liver regeneration and hepatocarcinogenesis, Hepatology 3:1016 (1983).

    Article  PubMed  CAS  Google Scholar 

  13. M. Goyette, C. J. Petropoulos, P. R. Shank, and N. Fausto, Regulated transcription of c-Ki-ras and c-myc during compensatory growth of rat liver, Mol. Cell Biol. 4:1493 (1984).

    PubMed  CAS  Google Scholar 

  14. N. L. Thompson, J. E. Mead, L. Braun, M. Gouette, P. R. Shank, and N. Fausto, Sequential protooncogene expression during rat liver regeneration, Cancer Res. 46:3111 (1986).

    PubMed  CAS  Google Scholar 

  15. R. Makino, K. Hayashi, and T. Sugimura, c-myc transcript is induced in rat liver at a very early stage of regeneration or by cycloheximide treatment, Nature 310:695 (1984).

    Article  Google Scholar 

  16. M. Corral, B. Paris, C. Guguen Guillouzo, D. Corcos, J. Kruh, and N. Defer, Increased expression of the N-myc gene during normal and neoplastic rat liver growth, Exptl. Cell Res. 174:107 (1988).

    Article  PubMed  CAS  Google Scholar 

  17. P. Coni, F. A. Bignone, G. Pichiri, G. M. Ledda-Columbano, A. Columbano, P. M. Rao, S. Rajalakshmi, and D. S. R. Sarma, Studies on the kinetiks of expression of cell cycle dependent proto-oncogenes during mitogen-induced liver cell proliferation, Cancer Lett. 476:115 (1989).

    Article  Google Scholar 

  18. R. Garcea, L. Daino, R. Pascale, M. M. Simile, M. Puddu, M. E. Ruggiu, M. A. Seddaiu, G. Satta, M. J. Sequenza, and F. Feo, Protooncogene methylation and expression in regenerating liver and preneoplastic liver nodules induced in the rat by diethylnitrosamine: effect of variations of S-adenosylmethionine: S-adenosylhomocysteine ratio, Carcinogenesis 10:1183 (1989).

    Article  PubMed  CAS  Google Scholar 

  19. F. Feo, R. Garcea, L. Diano, R. Pascale, L. Pirisi, S. Frassetto, and M. E. Ruggiu, Early stimulation of polyamine biosynthesis during promotion by phenobarbital of diethylnitrosamine-induced rat liver carcinogenesis. The effects of variations of the S-adenosyl-L-methionine cellular pool. Carcinogenesis 6:1713 (1985).

    Article  PubMed  CAS  Google Scholar 

  20. A. Hirvonen, ornithine decarboxylase activity and the accumulation of its mRNA during early stages of liver regeneration, Biochim. Biophys. Acta 1007:120 (1989).

    Article  PubMed  CAS  Google Scholar 

  21. E. Hölttä, L. Sistonen, and K. Alitalo, The mechanisms of ornithine decarboxylase deregulation in c-Ha-ras oncogene-transformed NIH T3T cells, J. Biol. Chem. 263:4500 (1988).

    PubMed  Google Scholar 

  22. C. Legraverend, E. Potter, A. Hölltä, K. Alitalo, and L. C. Andersson, Interleukin-2 induces a rapid increase in ornithine decarboxylase mRNA in a cloned murine T lymphocytic cell line, Exp. Cell Res. 181:273 (1989).

    Article  PubMed  CAS  Google Scholar 

  23. M. Goyette, C. J. Petropoulos, P. R. Shank, and N. Fausto, Expression of a cellular oncogene during liver regeneration, Science 219:510 (1983).

    Article  PubMed  CAS  Google Scholar 

  24. R. Muller, D. J. Salmon, J. M. Tremblay, M. J. Cline, and I. M. Verena, Differential expression of cellular oncogenes during pre-and post-natal development of the mouse, Nature 299:640 (1982).

    Article  PubMed  CAS  Google Scholar 

  25. X.-K. Zhang, Z. Wang, A. Lee, D.-P. Huang, and J.-F. Chiu, Differential expression of cellular oncogenes during rat liver development, Cancer Lett. 41:147 (1988).

    Article  PubMed  CAS  Google Scholar 

  26. E. Borek, and P. R. Srinivasan, The methylation of nucleic acids, Ann. Rev. Biochem. 35:275 (1966).

    Article  CAS  Google Scholar 

  27. L. P. Adams, and R. H. Burdon, in: “Molecular Biology of DNA Methylation,” Springer-Verlag, New York, (1985).

    Chapter  Google Scholar 

  28. D. Jahner, and R. Jaenisch, DNA methylation in early mammalian development, in: “DNA Methylation. Biochemistry and Biological Significance,” A. Razin, H. Cedar, and A. D. Riggs, eds., Springer-Verlag, New York, (1984).

    Google Scholar 

  29. A. Razin, DNA methylation patterns: formation and biological function, in: “DNA Methylation. Biochemistry and Biological Significance,” A. Razin, H. Cedar, and A. D. Riggs, eds., Springer-Verlag, New York, (1984).

    Google Scholar 

  30. J. H. Taylor, in: “DNA Methylation and Cellular Differentiation,” Springer Verlag, Vienna, (1984).

    Chapter  Google Scholar 

  31. H. Cedar, DNA Methylation and gene activity, Cell 53:3 (1988).

    Article  PubMed  CAS  Google Scholar 

  32. M. A. Blackman, and M. E. Koshland, Differentiation-specific methylation of the immunoglobulin heavy chain locus, in: “Biochemistry and Biology of DNA Methylation,” G. C. Cantoni and A. Razin, eds., Alan R. Liss Inc., New York, (1985).

    Google Scholar 

  33. J. N. Lepeyre, and F. F. Becker, 5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which result, Biochem. Biphys. Res. Commun. 87:698 (1979).

    Article  Google Scholar 

  34. D. Kanduc, A. Ghoshal, E. Quagliariello, and E. Farber, DNA hypomethylation in ethionine-induced rat preneoplastic hepatocyte nodules, Biochem. Biophys. Res. Commun. 150:739 (1988).

    Article  PubMed  CAS  Google Scholar 

  35. A. Razin, E. Feldmesser, T. Kafri, and M. Szyf, Cell specific DNA methylation patterns; formation and a nucleosome locking model for their function, in: “Biochemistry and Biology of DNA Methylation,” G. L. Cantoni, and A. Razin, eds., Alan R. Liss Inc., New York, (1985).

    Google Scholar 

  36. U. Siebenlist, L. Hennighause, J. Battey, and P. Leder, Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma, Cell 37:381 (1984).

    Article  PubMed  CAS  Google Scholar 

  37. P. J. Dyson, and T. H. Rabbitts, Chromatin structure around the c-myc gene in Burkitt lymphomas with upstream and downstream translocation points, Proc. Natl. Acad. Sci USA 82:1984 (1988).

    Article  Google Scholar 

  38. R. A. Gjerset, and D. W. Martin, Presence of DNA demethylating activity in the nucleus of murine erythroleukemia cells, J. Biol. Chem. 257:8581 (1982).

    PubMed  CAS  Google Scholar 

  39. P. M. Rao, A. Antony, S. Rajalakshmi, and D. S. R. Sarma, Studies on hypomethylation of liver DNA during early stages of chemical carcinogenesis in rat liver, Carcinogenesis 10:933 (1989).

    Article  PubMed  CAS  Google Scholar 

  40. F. Feo, R. Garcea, L. Daino, R. Pascale, S. Frassetto, P. Cozzolino, G. Vannini, M. E. Ruggiu, M. M. Simile, and M. Puddu, S-adenosylmethionine antipromotion and antiprogression effect in hepatocarcinogenesis. Its association with DNA methylation and inhibition of gene expression, in: “Chemical Carcinogenesis. Models and Mechanisms,” F. Feo, P. Pani, A. Columbano, and R. Garcea, eds., Plenum Publ. Corp., New York, (1988).

    Google Scholar 

  41. F. Feo, R. Pascale, M. M. Simile, M. E. Ruggiu, L. Daino, G. Satta, and M. A. Seddaiu, Chemoprevention of rat liver carcinogenesis by S-adenosylmethionine: Role of remodeling and apoptosis, in: “Modulatory Factors in Multistage Chemical Carcinogenesis,” A. Columbano, F. Feo, R. Pascale, and P. Pani, eds., Plenum Publ. Corp, New York, This volume.

    Google Scholar 

  42. I. Porsch-Hällström, A. Blank, L. C. Eriksson, and J. A. Gustafsson, Expression of c-myc, c-fos anc c-ras protooncogenes during sex-differentiated rat liver carcinogenesis in the resistant hepatocyte model, Carcinogenesis 10:1793 (1989).

    Article  PubMed  Google Scholar 

  43. S. J. Kerr, Competing methyltransferase system, J. Biol. Chem. 247:4248 (1972).

    PubMed  CAS  Google Scholar 

  44. R. Pascale, L. Daino, R. Garcea, S. Frassetto, M. E. Ruggiu, M. G. Vannini, P. Cozzolino, and F. Feo, Inhibition by ethanol of rat liver plasmamembrane (Na+,K+)ATPase: Protective effect of s-adenosyl-L-methionine, L-methionine and N-acetylcysteine, Toxicol. Appl. Pharmacol. 97:216 (1989).

    Article  PubMed  CAS  Google Scholar 

  45. R. Garcea, R. Pascale, L. Daino, S. Frassetto, P. Cozzolino, M. E. Ruggiu, M. G. Vannini, L. Gaspa, and F. Feo, Variations of ornithine decarboxylase activity and S-adenosyl-L-methionine and 5’-methylthioadenosine contents during the development of diethylnitrosamine-induced liver hyperplastic nodules and hepatocellular carcinomas, Carcinogenesis 8:653 (1987).

    Article  PubMed  CAS  Google Scholar 

  46. R. Garcea, L. Daino, R. Pascale, M. M. Simile, M. Puddu, S. Frassetto, P. Cozzolino, M. A. Seddaiu, L. Gaspa, and F. Feo, Inhibition of promotion and persistent nodule growth by S-adenosyl-L-methionine in rat liver carcinogenesis: Role of remodeling and apoptosis, Cancer Res. 49:1850 (1989).

    PubMed  CAS  Google Scholar 

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Simile, M.M. et al. (1991). S-Adenosylmethionine Content, DNA Methylation and Gene Expression in Regenerating Liver. In: Columbano, A., Feo, F., Pascale, R., Pani, P. (eds) Chemical Carcinogenesis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3694-9_5

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  • DOI: https://doi.org/10.1007/978-1-4615-3694-9_5

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