Abstract
Cellular death can be classified into two broad morphologic groups, necrosis (zonal cellular necrosis) and apoptosis (selective cell death)3,9–11,13. The former process often affects simultaneously a large number of contiguous cells, such as in case of vascular and oxygen deficiency. Apoptosis, on the other hand, often involves isolated cells, usually as part of cell turnover in the tissue. In apoptosing cells, changes have been described in both the nucleus and cytoplasm11,21 (a) nuclear swelling with fragmentation and clumping of the chromatin and (b) cytoplasmic condensation. In contrast to the scattering of cellular debris found in necrosis, cellular material in apoptosis is released as “packaged” apoptotic bodies, which appear to be phagocytized by adjacent viable cells. Again in contrast to necrosis, the functional integrity of the plasma membrane is retained in apoptosis, maintaining the cellular constituents in a confined space while as yet largely undefined biochemical processes alter the nuclear and cytoplasmic constituents.
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Amenta, J.S., Sargus, M.J., Bonelli, G., Baccino, F.M. (1991). An in Vitro Model for Apoptosis: Uptake and Degradation of Apoptotic Bodies. In: Columbano, A., Feo, F., Pascale, R., Pani, P. (eds) Chemical Carcinogenesis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3694-9_43
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DOI: https://doi.org/10.1007/978-1-4615-3694-9_43
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