Abstract
Hepatocarcinogenesis is followed by significant changes in lipid peroxidation rate. Normal liver is highly susceptible to lipoperoxidationl; the degree of hepatic basal lipid peroxidation can be strongly increased by pro-oxidant agents, such as ascorbate or ADF/Fe2+; the response to prooxidant substances is much lower both in hyperplastic nodules and in hepatomas induced by diethylnitrosamine (DEN)2. On the contrary, the increase of lipid peroxidation rate induced in liver membranes by a choline-deficient diet appears to be important in tumor promotion3.
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Rossi, M.A., Fidale, F., Garramone, A., Dianzani, M.U. (1991). Modulation of Phosphatidylinositol-4,5-Diphosphate (PIP2) Phospholipase C Activity by 4-Hydroxyalkenals. In: Columbano, A., Feo, F., Pascale, R., Pani, P. (eds) Chemical Carcinogenesis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3694-9_34
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DOI: https://doi.org/10.1007/978-1-4615-3694-9_34
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