Abstract
Several substantial differences in lipid composition of biomembranes have been found between normal and neoplastic tissues. The biomembranes of many types of cancer cells exhibit an increase of the cholesterol-to-phospholipid ratio, a decrease of the lipid-to-protein ratio and a decrease in polyunsaturated fatty acid content, as compared to those of normal cells.
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L. A. Morson, and M. T. Clandinin, Dietary linoleic acid modulates liver plasma membrane unsaturated fatty acid composition, phosphatidylcholine and cholesterol content, as well as glucagon stimulated adenylate cyclase activity, Nutrition Res. 5:1113 (1985).
E. Gravela, F. Feo, R. A. Canuto, R. Garcea, and L. Gabriel, Functional and structural alterations of liver ergastoplasmic membranes during DL-ethionine hepatocarcinogenesis, Cancer Res. 35:3041 (1975).
R. A. Canuto, M. E. Biocca, G. Muzio, and M. U. Dianzani, Fatty acid composition of phosholipids in mitochondria and microsomes during diethylnitrosamine carcinogenesis in rat liver, Cell Biochem. Funct. 7:11 (1989).
K. H. Cheeseman, S. Emery, S. P. Maddix, T. F. Slater, G. W. Burton, and K. U. Ingold, Studies on lipid peroxidation in normal and tumour tissues. The Yoshida rat liver tumour, Biochem. J. 250:247 (1988).
K. H. Cheeseman, M. Collins, K. Proudfoot, T. F. Slater, G. W. Burton, A. C. Webb, and K. U. Ingold, Studies on lipid peroxidation in normal and tumour tissues. The Novikoff rat liver tumour, Biochem. J. 235:507 (1986).
G. Medes, and S. Weinhouse, Metabolism of neoplastic tissue. XIII. Substrate competition in fatty acid oxidation in ascites tumor cells, Cancer Res. 18:352 (1958).
A. A. Spector, Fatty acid metabolism in tumors, Prog. Biochem. Pharmacol. 10:42 (1975).
G. Poli, E. Gravela, E. Albano, and M. U Dianzani, Studies on fatty liver isolated hepatocytes. II. The action of carbon tetrachloride on lipid peroxidation, protein and triglyceride synthesis and secretion, Exp. Mol. Pathol. 30:116 (1979).
T. F. Slater, and B. C. Sawyer, The stimulatory effects of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver fractions in vitro. I. general features of the systems used, Biochem. J. 123:805 (1971).
J. Folch, M. Lees, and G. Sloane Stanley, A simple method for the isolation and purification of total lipids from animal tissues, J. Biol. Chem. 226:497 (1957).
L. D. Metcalfe, and A. A. Schmitz, The rapid preparation of fatty acid esters for gas chromatographic analysis, Anal. Chem. 33:363 (1961).
A. G. Gornal, C. J. Bardawill, and M. David, Determination of serum proteins by means of the biuret reaction, J. Biol. Chem. 177:751 (1949).
E. D. Letendre, Iron metabolism during infection and neoplasia, Cancer Metast. Rev. 6:41 (1987).
D. G. Beer, and H. C. Pitot, Biological markers characterizing the development of preneoplastic and neoplastic lesions in rodent liver, Arch. Toxicol. suppl. 10:68 (1987).
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© 1991 Springer Science+Business Media New York
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Muzio, G., Canuto, R.A., Biocca, M.E., Dianzani, M.U. (1991). Arachidonic Acid Enrichment Augments the Malonildialdehyde Production in Yoshida AH-130 Hepatoma Cells. In: Columbano, A., Feo, F., Pascale, R., Pani, P. (eds) Chemical Carcinogenesis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3694-9_33
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DOI: https://doi.org/10.1007/978-1-4615-3694-9_33
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