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Arachidonic Acid Enrichment Augments the Malonildialdehyde Production in Yoshida AH-130 Hepatoma Cells

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Chemical Carcinogenesis 2
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Abstract

Several substantial differences in lipid composition of biomembranes have been found between normal and neoplastic tissues. The biomembranes of many types of cancer cells exhibit an increase of the cholesterol-to-phospholipid ratio, a decrease of the lipid-to-protein ratio and a decrease in polyunsaturated fatty acid content, as compared to those of normal cells.

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References

  1. L. A. Morson, and M. T. Clandinin, Dietary linoleic acid modulates liver plasma membrane unsaturated fatty acid composition, phosphatidylcholine and cholesterol content, as well as glucagon stimulated adenylate cyclase activity, Nutrition Res. 5:1113 (1985).

    Article  CAS  Google Scholar 

  2. E. Gravela, F. Feo, R. A. Canuto, R. Garcea, and L. Gabriel, Functional and structural alterations of liver ergastoplasmic membranes during DL-ethionine hepatocarcinogenesis, Cancer Res. 35:3041 (1975).

    PubMed  CAS  Google Scholar 

  3. R. A. Canuto, M. E. Biocca, G. Muzio, and M. U. Dianzani, Fatty acid composition of phosholipids in mitochondria and microsomes during diethylnitrosamine carcinogenesis in rat liver, Cell Biochem. Funct. 7:11 (1989).

    Article  PubMed  CAS  Google Scholar 

  4. K. H. Cheeseman, S. Emery, S. P. Maddix, T. F. Slater, G. W. Burton, and K. U. Ingold, Studies on lipid peroxidation in normal and tumour tissues. The Yoshida rat liver tumour, Biochem. J. 250:247 (1988).

    PubMed  CAS  Google Scholar 

  5. K. H. Cheeseman, M. Collins, K. Proudfoot, T. F. Slater, G. W. Burton, A. C. Webb, and K. U. Ingold, Studies on lipid peroxidation in normal and tumour tissues. The Novikoff rat liver tumour, Biochem. J. 235:507 (1986).

    PubMed  CAS  Google Scholar 

  6. G. Medes, and S. Weinhouse, Metabolism of neoplastic tissue. XIII. Substrate competition in fatty acid oxidation in ascites tumor cells, Cancer Res. 18:352 (1958).

    PubMed  CAS  Google Scholar 

  7. A. A. Spector, Fatty acid metabolism in tumors, Prog. Biochem. Pharmacol. 10:42 (1975).

    PubMed  CAS  Google Scholar 

  8. G. Poli, E. Gravela, E. Albano, and M. U Dianzani, Studies on fatty liver isolated hepatocytes. II. The action of carbon tetrachloride on lipid peroxidation, protein and triglyceride synthesis and secretion, Exp. Mol. Pathol. 30:116 (1979).

    Article  PubMed  CAS  Google Scholar 

  9. T. F. Slater, and B. C. Sawyer, The stimulatory effects of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver fractions in vitro. I. general features of the systems used, Biochem. J. 123:805 (1971).

    PubMed  CAS  Google Scholar 

  10. J. Folch, M. Lees, and G. Sloane Stanley, A simple method for the isolation and purification of total lipids from animal tissues, J. Biol. Chem. 226:497 (1957).

    PubMed  CAS  Google Scholar 

  11. L. D. Metcalfe, and A. A. Schmitz, The rapid preparation of fatty acid esters for gas chromatographic analysis, Anal. Chem. 33:363 (1961).

    Article  CAS  Google Scholar 

  12. A. G. Gornal, C. J. Bardawill, and M. David, Determination of serum proteins by means of the biuret reaction, J. Biol. Chem. 177:751 (1949).

    Google Scholar 

  13. E. D. Letendre, Iron metabolism during infection and neoplasia, Cancer Metast. Rev. 6:41 (1987).

    Article  CAS  Google Scholar 

  14. D. G. Beer, and H. C. Pitot, Biological markers characterizing the development of preneoplastic and neoplastic lesions in rodent liver, Arch. Toxicol. suppl. 10:68 (1987).

    Article  PubMed  CAS  Google Scholar 

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© 1991 Springer Science+Business Media New York

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Muzio, G., Canuto, R.A., Biocca, M.E., Dianzani, M.U. (1991). Arachidonic Acid Enrichment Augments the Malonildialdehyde Production in Yoshida AH-130 Hepatoma Cells. In: Columbano, A., Feo, F., Pascale, R., Pani, P. (eds) Chemical Carcinogenesis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3694-9_33

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  • DOI: https://doi.org/10.1007/978-1-4615-3694-9_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6642-3

  • Online ISBN: 978-1-4615-3694-9

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