Abstract
Competition radioligand binding studies were performed with 125I-BOP, a thromboxane A2 (TXA2) mimetic, in washed platelets and cultured rat aortic smooth muscle cells (RASMC) to determine if subtypes of TXA2 receptors exist in these two cell types. The rank order potency of a series of 13-azapinane TXA2 analogues to compete with 125I-BOP for binding in washed platelets and RASMC was significantly different. The regulation of the TXA2 receptor in cultured RASMC by sex steroids was also investigated. Testosterone but not estradiol 17-β significantly increased the number of TXA2 receptors inRASMC. The results support the notion that subtypes of TXA2 receptors exist in platelets and RASMC and that the expression of the receptors is influenced by testosterone.
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Halushka, P.V., Mais, D.E., Masuda, A., Matsuda, K., Morinelli, T., Oatis, J.E. (1993). Thromboxane A2 Receptors: Characterization and Regulation. In: Nigam, S., Honn, K.V., Marnett, L.J., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury. Developments in Oncology, vol 71. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3520-1_33
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