Abstract
The total population of all Scandinavian countries is about 22 million. These countries have a similar social structure, a modern medical service covering all inhabitants, and an effective registration system for all cancer patients. Based on these similarities, the Scandinavian Sarcoma Group (SSG) was founded in 1979 with the intention of improving the prognosis for patients with sarcoma. In the first study period 1982–1989, a nonrandomized trial based on Rosen’s T10 protocol [1] for patients with operable osteosarcoma was used. Preliminary results have been published [2], and the complete data are currently under analysis. The second study, started in April 1990 and is based on the results and experience obtained from the preceding protocol and recent reports from other centres. This article gives an update of both trials. In addition, the Finnish 10-year results of osteosarcoma treatment are reviewed [3].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Rosen G, Caparros B, Huvos AG, et al. Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of primary tumor to preoperative chemotherapy. Cancer 49:1221–1230, 1982.
Solheim Ö, Alvegård TA, Elomaa I. Adjuvant chemotherapy for osteosarcoma. A preliminary report from the Scandinavian Sarcoma Group. Acta Oncol 28(Suppl 2):53–57, 1989.
Elomaa I, Siimes M, Blomqvist C, et al. Ten years’ experience in patients with osteogenic sarcoma in Finland. Eur J Surg Oncol 16:147–152, 1990.
Rosen G, Marcove RG, Caparros B, et al. Primary osteogenic sarcoma. The rationale for preoperative chemotherapy and delayed surgery. Cancer 43:2163–2177, 1979.
Siimes MA, Elomaa I, Koskimies A. Testicular function after chemotherapy for osteosarcoma. Eur J Cancer 26:973–975, 1990.
Saeter G, Alvergård TA, Elomaa I, Solheim Ö. Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with single agent high-dose methotrexate. A Scandinavian Sarcoma Group Study. Clin Oncol 9:1766–1775, 1991.
Winkler K. COSS-86. Kooperative osteosarkomstudie. Therapie-protokoll. Gesellschaft für pädiatrische Oncologic, Hamburg, 1987.
Weiner MA, Harris MB, Lewis M, et al. Neoadjuvant high-dose methotrexate, cisplatin and doxorubicin, for management of patients with nonmetastatic osteosarcoma. Cancer Treat Rep 70:1431–1432, 1986.
Zalupski M, Baker LH. Ifosfamide. J Natl Cancer Inst 80:556–566, 1988.
Scandinavian Sarcoma Group. The treatment of osteosarcoma. Trial protocol of SSG VIII, prepared by the Working Committee of the SSG. SSG Secretariat, Oncologic Center Lund, Sweden.
Meistrich ML, Chawla CP, Da Cunha MF, et al. Recovery of sperm production after chemotherapy for osteosarcoma. Cancer 63:2115–2123, 1989.
Friend SH, Bernands RR. A human DNA segment with properties of the gene that predisposes to retinobastoma and osteosarcoma. Nature 323:646–664, 1986.
Hiddeman W, Rosner A, Wormann B, et al. Tumor heterogenity in osteosarcoma as identified by flow cytometry. Cancer 59:324–328, 1987.
Mandahl N, Rydholm A. Cytogenetic abnormalities in tumors of bone and soft tissues. Acta Oncol 28(Suppl 2):69–73.
Karaharju E, Knuutila S, Elomaa I. Chromosome study in bone tumors. Acta Scand Traumt Orthoped 61:235, 1990.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Elomaa, I. (1993). An update of Scandinavian studies of osteosarcoma. In: Humphrey, G.B., Koops, H.S., Molenaar, W.M., Postma, A. (eds) Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies. Cancer Treatment and Research, vol 62. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3518-8_35
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3518-8_35
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6561-7
Online ISBN: 978-1-4615-3518-8
eBook Packages: Springer Book Archive