Abstract
Cisplatin (CDDP) is one of the most effective chemotherapeutic agents in the treatment of osteosarcoma used as neoadjuvant and adjuvant treatment. The potential effectiveness of CDDP is limited due to nephrotoxicity and ototoxicity. With isolated limb perfusion (ILP), followed by an exchange transfusion of the perfusate and whole blood, it is possible to attain very high local drug concentrations in a limb with minimal systemic toxicity. The biological behavior of canine osteosarcoma is similar to human osteosarcoma. The tumor occurs predominantly in the long bones, with early hematogenous metastases to the lungs [1]. The efficacy of ILP with CDDP on osteosarcoma was studied in spontaneous canine osteosarcomas to provide guidelines for its clinical use.
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© 1993 Springer Science+Business Media New York
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Hoekstra, H.J., Meutstege, F.J., Oosterhuis, J.W., De Vries, J., Koops, H.S. (1993). Effect of isolated limb perfusion with cisplatin (CDDP) on canine osteosarcoma. In: Humphrey, G.B., Koops, H.S., Molenaar, W.M., Postma, A. (eds) Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies. Cancer Treatment and Research, vol 62. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3518-8_29
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DOI: https://doi.org/10.1007/978-1-4615-3518-8_29
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