Abstract
In 1964, Abe et al. [1] developed intraoperative radiotherapy (IOR) for advanced abdominal cancers with significantly better local control than other methods. Since 1978 we have used IOR in combination with chemotherapy for treating primary and metastatic malignant bone tumors in an attempt to preserve the affected limb [2]. In 1983 we demonstrated by serial histological examination of the removed tumors receiving IOR that direct irradiation of a large dose (50–60 Gy) of electron beams was extremely effective in controlling local lesions in the extremities, although IOR was not considered to have any influence on the survival rate of the patient [3].
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References
Abe M, Takahashi M, Yabumoto E. Techniques, indications, and results of intraoperative radiotherapy of advanced cancers. Radiology 16:693–702, 1975.
Yamamuro T, Kotoura Y, Nagashima T, et al. Ten year experience of intraoperative radiotherapy for malignant tumors arising in four extremities. J Jpn Orthop Assoc 57:1147–1148, 1983.
Nagashima T, Yamamuro T, Kotoura Y, et al. Histological studies on the effect of intraoperative irradiation of osteosarcoma. J Jpn Orthop Assoc 57:1681–1697, 1983.
Yamamuro T, Kotoura Y, Kasahara K, et al. Intraoperative radiotherapy and ceramic prosthesis replacement for osteosarcoma. In: New Development for Limb Salvage in Musculoskeletal Tumors. Yamamuro T, Ed. Springer-Verlag, Tokyo, 1989, pp 327–333.
Yamamuro T, Kotoura Y, Kasahara K, et al. Limb salvage with the intraoperatively irradiated tumor tissues preserved in situ in osteosarcoma. In: Limb Salvage, Major Reconstructions in Oncologic and Nontumoral Conditions. Langlais F & Tomeo B, Eds. Springer-Verlag, Berlin Heidelberg, 1991, pp. 619–625.
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Yamamuro, T., Kotoura, Y. (1993). Intraoperative radiation therapy for osteosarcoma. In: Humphrey, G.B., Koops, H.S., Molenaar, W.M., Postma, A. (eds) Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies. Cancer Treatment and Research, vol 62. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3518-8_21
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DOI: https://doi.org/10.1007/978-1-4615-3518-8_21
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