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Pathological diagnosis of osteosarcoma: The validity of the subclassification and some new diagnostic approaches using immunohistochemistry

  • Chapter
Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 62))

Abstract

Osteosarcoma of bone is a disease with considerable histologic and anatomic heterogeneity affecting the biological behavior of the tumor. On the basis of clinical features, anatomic location, histologic subtype, cytologic grading, and biological behavior, Dahlin and Unni [1] subclassified osteosarcoma into a “conventional” type and 11 important recognizable varieties, a system that has been generally utilized over the last 15 years. These days, however, our knowledge of osteosarcoma has greatly increased, compelling us to modify the original implications of those entities and to add a few novel varieties. Moreover, estimation of biological behavior is another important problem that should be settled by pathologists. Thus far, we have found no effective indicator other than cytological grading.

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Authors and Affiliations

  1. Gerhard-Domagk Institute for Pathology, University of Munster, Domagkstr. 17, D-4400, Munster, Germany

    Yoshimichi Ueda, Albert Roessner & Ekkehard Grundmann

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  1. Yoshimichi Ueda
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  2. Albert Roessner
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  3. Ekkehard Grundmann
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Editors and Affiliations

  1. Medical College of Ohio at Toledo, USA

    G. Bennett Humphrey

  2. University of Groningen, Netherlands

    H. Schraffordt Koops , W. M. Molenaar  & A. Postma ,  & 

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Ueda, Y., Roessner, A., Grundmann, E. (1993). Pathological diagnosis of osteosarcoma: The validity of the subclassification and some new diagnostic approaches using immunohistochemistry. In: Humphrey, G.B., Koops, H.S., Molenaar, W.M., Postma, A. (eds) Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies. Cancer Treatment and Research, vol 62. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3518-8_15

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