Abstract
Diabetic patients with hypertension show a high incidence of the development of heart failure. The mechanisms involved in heart failure at the myocardial cellular level remain unclear. To elucidate the myocardial alterations occurring in hypertension associated with diabetes, we examined myocardial contractility and ventricular myosin isoenzymes in diabetic spontaneously hypertensive rats (SHR). Myocardial contractility was assessed by measuring the isometric tension developed in isolated left ventricular papillary muscles, and ventricular myosin isoenzymes were separated by pyrophosphate gel electrophoresis.
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References
Hoh JFY, McGrath PA, Hale PT. Electrophoretic analysis of multiple forms of rat cardiac myosin: Effects of hypophysectomy and thyroxin replacement. J Mol Cell Cardiol 1978;10:1053–1076.
d’sAlbis A, Pantaloni C, Becher JJ. An electrophoretic study of native myosin isoenzymes and of their subunit content. Eur J Biochem 1979;99:261–272.
Rupp H, Jacob R. Response of blood pressure and cardiac myosin polymorphism to swimming training in the spontaneously hypertensive rat. Can J Physiol Pharmacol 1982;60:1098–1103.
Takeda N, Ohkubo T, Nakamura I, Suzuki H, Nagano M. Mechanical catecholamine responsiveness and myosin isoenzyme pattern of pressure-overloaded rat ventricular myocardium. Basic Res Cardiol 1987;82:370–374.
Penpargkul S, Fein F, Sonnenblick EH, Scheuer J. Depressed cardiac sarcoplasmic reticular function from diabetic rats. J Mol Cell Cardiol 1981,13:303–309.
Ganguly PK, Pierce GN, Dhalla KS, Dhalla NS. Defective sarcoplasmic reticular calcium transport in diabetic cardiomyopathy. Am J Physio1 1983;244:E528-E535.
Lopaschuk GD, Katz S, McNeill JH. The effect of alloxan-and streptozotocin-induced diabetes on calcium transport in rat cardiac sarcoplasmic reticulum. The possible involvement of long chain acylcarnitines. Can J Physiol Pharmacol 1983;61:439–448.
Ebrecht G, Rupp H, Jacob R. Alterations of mechanical parameters in chemically skinned preparations of rat myocardium as a function of isoenzyme pattern of myosin. Basic Res Cardiol 1982;77:220–234.
Jacob R, Kissling G, Rupp H, Vogt M. Functional significance of contractile proteins in cardiac hypertrophy and failure. J Cardiovasc Pharmacol 1987;10(suppl 6):2–12.
Imai S, Otorii T, Takeda K, Katano Y, Horii D. Effects of cyclic AMP and dibutyryl cyclic AMP on the heart and coronary circulation. Jpn J Pharmacol 1974;24:499–510.
Takeda N, Dominiak P, Türck D, Rupp H, Jacob R. The influence of endurance training on mechanical catecholamine responsiveness, B-adrenoceptor density and myosin isoenzyme pattern of rat ventricular myocardium. Basic Res Cardiol 1985;80:88–99.
Takeda N, Dominiak P, Tiirck D, Rupp H, Jacob R. Myocardial catecholamine responsiveness of spontaneously hypertensive rats as influenced by swimming training. Basic Res Cardiol 1985;80:384–391.
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© 1992 Springer Science+Business Media New York
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Takeda, N. et al. (1992). The Influence of Diabetes on Myocardial Contractility and Energetics in Spontaneously Hypertensive Rats. In: Nagano, M., Mochizuki, S., Dhalla, N.S. (eds) Cardiovascular Disease in Diabetes. Developments in Cardiovascular Medicine, vol 130. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3512-6_9
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DOI: https://doi.org/10.1007/978-1-4615-3512-6_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6558-7
Online ISBN: 978-1-4615-3512-6
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