Abstract
Severe experimental diabetes, induced by streptozotocin in a dose of 65 mg/kg body weight, resulting in blood glucose levels of 500 mg/dl, leads to a cardiomyopathy, characterized by reduced cardiac output, due to reduced stroke volume and reduced heart rate. Investigating these hearts in the isolated working rat heart model, the development of a cardiomyopathy can be seen after 1 week of diabetes as well as after 2 weeks, 8 weeks, 16 and 24 weeks (1,2,3).
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References
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© 1992 Springer Science+Business Media New York
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Stroedter, D., Schmitt, M., Broetz, T., Federlin, K., Schaper, W. (1992). Reversibility of Diabetic Cardiomyopathy by Therapeutic Interventions in Mild Diabetes. In: Nagano, M., Mochizuki, S., Dhalla, N.S. (eds) Cardiovascular Disease in Diabetes. Developments in Cardiovascular Medicine, vol 130. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3512-6_30
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DOI: https://doi.org/10.1007/978-1-4615-3512-6_30
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