Abstract
It is well known that patients with diabetes mellitus are frequently associated with atherosclerotic diseases such as hypertension and/or ischemic heart diseases (1–4). Recently, there are reports that some cases with diabetic cardiomyopathy have no obvious genesis but are accompanied with chronic congestive heart failure (5,6). In experimentally diabetic animals, it has been noted that chronotropic and inotropic actions of beta-adrenoceptor stimulating agents (beta agonists) diminished in isolated myocardium (7–9), and concomitant decrease in the number of beta-adrenoceptor might be responsible for these reduced myocardial functions (7–9). On the other hand, beta-adrenoceptor blocking agents (beta blockers) have generally been used for the therapy of hypertension and/or ischemic heart diseases accompanied with diabetes mellitus (10,11). When beta blockers are administered to patients with diabetic mellitus, their influences on lipids metabolism, hypoglycemia and/or secretion of insulin have been taken into account (12,13), but this is not the case with respect to myocardial function. If the decrease in the number of beta adrenoceptor is related to reduced myocardial function, then great attention must be paid to the use of beta blockers in diabetic patients. In the present study, therefore, to evaluate experimentally the influence of beta-blockers on diabetic myocardium, effects of propranolol with beta1 and beta2 adrenoceptor blocking activity as a standard beta blocker, and atenolol with beta1 adrenoceptor blocking activity as a cardioselective beta blocker on isoproterenol-induced responses of both atrial and papillary muscles isolated from experimentally diabetic rats were examined.
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Nagamine, F., Sunagawa, R., Murakami, K., Sakanashi, M., Mimura, G. (1992). Effects of Beta-Adrenoceptor Blocking Agents on Myocardium Isolated from Experimentally Diabetic Rats. In: Nagano, M., Mochizuki, S., Dhalla, N.S. (eds) Cardiovascular Disease in Diabetes. Developments in Cardiovascular Medicine, vol 130. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3512-6_26
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DOI: https://doi.org/10.1007/978-1-4615-3512-6_26
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