Abstract
Hypertension occurs with greater frequency in diabetic than in non- diabetic patients, and when heart failure develops in these patients it is occasionally resistant to therapy. Clinically, numerous reports have indicated a close relationship between diabetes and hypertension. Hypertension and diabetes mellitus (DM) both show a wide prevalence in humans; they can cause a number of myocardial deficiencies, resulting in a strikingly increased incidence of heart failure. The present study investigated the influence of hypertension, diabetes, and their combination on cardiac function and cardiac contractile proteins in Wistar rats.
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References
Kaplan NM. The Goldblatt Memorial Lecture, Part II. The role of the kidney in hypertension. Hypertension 1979;1:456–461.
Stracher A. Evidence for the involvement of light chains in the biological functioning of myosin. Biochem Biophys Res Commun 1969;35:519–525.
Medugorac I. Characteristics of the hypertrophied left ventricular myocardium in Goldblatt rats. Basic Res Cardiol 1977;72:261–267.
Hoh JFY, McGrath PA and Hale PT. Electrophoretic analysis of multiple forms of rat cardiac myosin: Effects of hypophysectomy and thyroxine replacement. J Mol Cell Cardiol 1977; 10:1053–1076.
Dowel RT, Cutilletta AF and Sodt PC. Functional evaluation of the rat heart in situ. J Appl Physiol 1975;39:1043–1047
Fein FS, Cho S, Zola BE, Miller B and Factor SM. Cardiac pathology in the hypertensive diabetic rat. Biventricular damage with right ventricular predominance. Am J Pathol 1989;134:1159–1166-
Factor SM, Minase T, Cho S, Fein F, Capasso JM and Sonnenblick EH. Coronary microvascular abnormalities in the hypertensive-diabetic rat. A primary case of cardiomyopathy? Am J Pathol 1984;116:9–20.
Fein FS, Capasso JM, Aronson RS, Cho S, Nordin C, Miller-Green B, Sonnenblick EH and Factor SM. Combined renovascular hypertension and diabetes in rats: A new preparation of congestive cardiomyopathy. Circulation 1984;70:318–330.
Factor SM, Bhan R, Minase T, Wolinsky H and Sonnenblick EH. Hypertensive-diabetic cardiomyopathy in the rat. An experimental model of human disease. Am J Pathol 1981; 102:218–228.
Mall G, Klingel K, Baust H, Hasslacher Ch, Mann J, Mattfeldt T and Waldherr R. Synergistic effects of diabetes mellitus and renovascular hypertension on the rat heart-stereological investigations on papillary muscles. Virchows Arch A 1987;411:531–542.
Rodgers RL. Depressor effect of diabetes in the spontaneously hypertensive rat: Associated changes in heart performance. Can J Physiol Pharmacol 1985;64:1177–1184.
Takeda N, Nakamura I, Hatanaka T, Ohkubo T. and Nagano M. Myocardial mechanical and myosin isoenzyme alterations in streptozotocin-diabetic rats. Jap Heart J 1988;29:455–463.
Rupp H, Kissling G and Jocob R. Hormonal and hemodynamic determinants of polymorphic myosin. In: Perspectives in Cardiovascular Research, Vol. 7. Katz, AM (ed). Raven Press, New York, 1983, pp.373–383.
Schwartz K, Lompre AM, Lacombe G, Bouveret P, Wisnewsky C, Whalen RG, D’Albis A and Swynghedauw B. Cardiac myosin isoenzymic transitions in mammals. In: Perspectives in Cardiovascular Research, Vol 7. Katz, AM (ed). Raven Press, New York, 1983, pp.345–358.
Carey RA, Natarajan G, Bove AA, Coulson RL and Spann JF. Myosin adenosine triphosphatase activity in the volume-overloaded hypertrophied feline right ventricle. Circ Res 1979;45:81–87.
Scheuer J and Bahn AK. Cardiac contractile proteins. Adenosine triphosphatase activity and physiological function. Circ Res 1978;45:1–12.
Fein FS, Kornstein LB, Strobeck JE, Capasso JM and Sonnenblick EH. Altered myocardial mechanics in diabetic rats. Circ Res 1980;47:922–933.
Pierce GN and Dhalla NS. Cardiac myofibrillar ATPase activity in diabetic rats. J Mol Cell Cardiol 1981; 13:1063–1069.
Takeda N, Nakamura I, Ohkubo T, Hatanaka T and Nagano M. Effects of physical training on the myocardium of streptozotocin-induced diabetic rats. Basic Res Cardiol 1988;83:525–530.
Jacob R, Ebrecht G, Holubarsch CH, Rupp H and Kissling G. Mechanics and energetics in cardiac hypertrophy as related to the isoenzyme pattern of myosin. Perspectives in Cardiovascular Research, Vol. 7. Katz, AM. (ed.) Raven Press, New York, 1983, pp. 553–569.
Spech MM, Ferrario CM and Tarazi RC. Cardiac pumping ability following reversal of hypertrophy and hypertension in spontaneously hypertensive rats. Hypertension 1980;2:75–82.
Pfeffer JM, Pfeffer MA and Braunwald E. Development of left ventricular dysfunction in the female spontaneously hypertensive rats. In: Perspectives in Cardiovascular Research, Vol. 7. Katz, AM. (ed.) Raven Press, New York, 1983, pp.73–84.
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© 1992 Springer Science+Business Media New York
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Kato, M. et al. (1992). Combined Effects of Hypertension and Diabetes on Myocardial Contractile Proteins and Cardiac Function in Rats. In: Nagano, M., Mochizuki, S., Dhalla, N.S. (eds) Cardiovascular Disease in Diabetes. Developments in Cardiovascular Medicine, vol 130. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3512-6_11
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DOI: https://doi.org/10.1007/978-1-4615-3512-6_11
Publisher Name: Springer, Boston, MA
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