Abstract
Hypertension and diabetes have been demonstrated to increase the risk of developing a cardiomyopathy in man (1,2). Our group previously described contractile, biochemical and ultrastructural properties of myocardium in rats with diabetes or renovascular hypertension (3–6). There were no direct biochemical comparisons made in the hearts of hypertensive, diabetic, hypertensive-diabetic and control rats derived from the same overall group of animals. Histological studies in a rat model with combined renovascular hypertension and diabetes show significant myocardial pathology with evidence of myocyte necrosis, replacement and interstitial fibrosis and possible microvascular spasm (7,8). Recent studies of isolated perfused heart function in spontaneously hypertensive and normotensive rats with and without diabetes strongly suggest that a combination of hypertension and diabetes results in greater cardiac dysfunction than that which occurs with hypertension or diabetes alone (9–11). Contractile protein biochemistry (myosin ATPase from left ventricular samples and myosin isoenzyme distribution from both left and right ventricular samples) was correlated to the papillary muscle function in these animals (12). The relative contribution of hypertension and diabetes to myocardial dysfunction in hypertensive-diabetic rats could be assessed from the present biochemical studies.
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© 1992 Springer Science+Business Media New York
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Malhotra, A. (1992). Hypertensive- Diabetic Cardiomyopathy in Rats. In: Nagano, M., Mochizuki, S., Dhalla, N.S. (eds) Cardiovascular Disease in Diabetes. Developments in Cardiovascular Medicine, vol 130. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3512-6_10
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DOI: https://doi.org/10.1007/978-1-4615-3512-6_10
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