Abstract
Many grading systems, both architectural and cytologic, have been developed to assess the metastatic potential of prostate cancers. These quantitative techniques have been applied to the prediction of prognosis based on the study of fixed dead cancer cells. Until recently, methods did not exist to enable the study of the dynamic biological properties of live cancer cells. Time-lapse videomicroscopy of living cancer cells has revealed that some cancer cells demonstrate dynamic motility processes. Cancer, often called a disease of cell structure, has been recognized histologically by pathologists for over 100 years by its altered morphology. The diversity of cell shape and size among cancer cells, first noted by Virchow in 1863 [1], is still described by pathologists through the static analysis of fixed, dead cells and only represents a “freeze-frame” of the more dynamic motility events occurring within the live cancer cells.
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© 1992 Springer Science+Business Media New York
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Partin, A.W., Mohler, J.L., Coffey, D.S. (1992). Cell motility as an index of metastatic ability in prostate cancers: Results with an animal model and with human cancer cells. In: Lepor, H., Lawson, R.K. (eds) Therapy for Genitourinary Cancer. Cancer Treatment and Research, vol 59. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3502-7_11
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DOI: https://doi.org/10.1007/978-1-4615-3502-7_11
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