Abstract
There are several reports indicating that oncogenes are associated with breast cancer in humans and animals (1,2). Among the oncogenes, the ras family with their three variants, c-Ha-ras, v-Ha-ras and n-Ha-ras, has been widely studied and reported to be involved in mammary carcinomas induced in experimental animals by chemical carcinogens, in breast cancer cell lines, in primary breast cancers, as rare alleles or as an amplification or expression of the gene product of the ras gene, the p21 protein (3 – 6). However, whether the ras oncogene is a causative agent of breast cancer has not been proven as yet.
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Russo, J., Calaf, G., Ochieng, J., Russo, I.H., Tahin, Q., Zhang, PL. (1992). Role of Ras Oncogene in Human Breast Cancer: An Experimental Approach. In: Dogliotti, L., Sapino, A., Bussolati, G. (eds) Breast Cancer: Biological and Clinical Progress. Developments in Oncology, vol 69. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3494-5_8
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