Abstract
Many compounds that show antitumor activity are known to bind to DNA (1). In order to rationally design antitumor drugs, we felt that a greater knowledge of the process was needed. Studies on a number of natural products with antitumor activity, derivatives of acridine, phenanthridine and other small ring systems had been conducted over the past three decades, but no definitive overview of this phenomenon existed.
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References
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Bair, K.W. (1992). 2-((Arylmethyl)Amino)-1, 3-Propanediols (AMAPS); Discovery, Selection and Development of Four Clinical Candidates. In: Valeriote, F.A., Corbett, T.H., Baker, L.H. (eds) Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development. Developments in Oncology, vol 68. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3492-1_6
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DOI: https://doi.org/10.1007/978-1-4615-3492-1_6
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