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The Biology and Prevention of Aerodigestive Tract Cancers pp 81–88Cite as

Growth Factors and Other Targets for Rational Application as Intervention Agents

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 320))

Abstract

Lung cancer is the leading cause of cancer deaths in the American society, with a mortality rate of close to 90% (1). The recalcitrance of lung cancer despite modern treatment approaches reflects the frequency of metastatic spread and the lack of effective systemic chemotherapeutic agents to eliminate disseminated cancer. Because of the lack of progress in treating metastatic lung cancer, new strategies for lung cancer control (prevention, early detection, and intervention) are being studied. Primary prevention efforts, such as the California state government’s large cigarette sales tax mandated by Proposition 99, are beginning to show remarkable results in reducing cigarette consumption (2). Efforts to improve the early detection of lung cancer are also beginning to show signs of promise (3–5). Complementing these are positive developments in the area of intervention therapy for very early lung cancer.

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Author information

Authors and Affiliations

  1. Biomarkers and Prevention Research Branch, National Institutes of Health, Bethesda, Maryland, USA

    James L. Mulshine, Michael Birrer, Anthony M. Treston, Frank Scott, Kathryn Quinn, Ingalill Avis & Frank Cuttitta

  2. Education and Community Oncology Program, National Institutes of Health, Bethesda, Maryland, USA

    James L. Mulshine, Michael Birrer, Anthony M. Treston, Frank Scott, Kathryn Quinn, Ingalill Avis & Frank Cuttitta

  3. Division of Cancer Prevention and Cancer Control, National Institutes of Health, Bethesda, Maryland, USA

    James L. Mulshine, Michael Birrer, Anthony M. Treston, Frank Scott, Kathryn Quinn, Ingalill Avis & Frank Cuttitta

  4. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    James L. Mulshine, Michael Birrer, Anthony M. Treston, Frank Scott, Kathryn Quinn, Ingalill Avis & Frank Cuttitta

Authors
  1. James L. Mulshine
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  2. Michael Birrer
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  3. Anthony M. Treston
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  4. Frank Scott
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  5. Kathryn Quinn
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  6. Ingalill Avis
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  7. Frank Cuttitta
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Editor information

Editors and Affiliations

  1. The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA

    Guy R. Newell  & Waun Ki Hong  & 

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© 1992 Springer Science+Business Media New York

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Mulshine, J.L. et al. (1992). Growth Factors and Other Targets for Rational Application as Intervention Agents. In: Newell, G.R., Hong, W.K. (eds) The Biology and Prevention of Aerodigestive Tract Cancers. Advances in Experimental Medicine and Biology, vol 320. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3468-6_11

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  • DOI: https://doi.org/10.1007/978-1-4615-3468-6_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6536-5

  • Online ISBN: 978-1-4615-3468-6

  • eBook Packages: Springer Book Archive

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