Abstract
Prevention of disease has always been more effective than treatment. Sanitation practices and vaccines have eliminated many of the most dreaded and lethal diseases of man and domestic animals. Cancer, a devastating disease caused by unregulated growth of genetically altered cells, is as daunting a challenge today as smallpox was in Edward Jenner’s time two centuries ago. Fortunately, we are on the threshold of a new era in biology. We can now examine growth-regulatory mechanisms at the cellular and molecular levels, and we can begin to apply what we learn in new clinical and experimental systems.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hong WK, Lippman SM, Itri LM, Karp DD, Lee JS, Byers RM, Schantz SP, Kramer AM, Lotan R, Peters LJ, Dimery IJ, Brown BW, Gocpfert H. Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck. N Engl J Med 323:795–801, 1990.
Lotan R. Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochim Biophys Acta 605:33–91,1980.
Tong PS, Horowitz NN, Wheeler LA. Trans retinoic acid enhances the growth response of epidermal keratinocytes to epidermal growth factor and transfbrn7ing growth factor beta. J Invest Dermatol 94:126–131, 1990.
Kimmel KA, Carey TE. Altered expression in squamous carcinoma cells of an orientation restricted epithelial antigen detected by monoclonal antibody A9. Cancer Res 46:3614–3623,1986.
Wolf GT, Carey TE, Schmaltz SP, Mc Clatchey KD, Poore J, Glaser L, Hayashida DJS, Hsu S. Altered antigen expression predicts outcome in squamous cell carcinoma of the head and neck. J Natl Cancer Inst 82:156fí-1572, 1990.
Van Waes C, Koarsky KF, Warren AB, Kidd L, Paugh D, Lichen M, Carey TE. The A9 antigen associated with aggressive human squamous carcinoma has structural and functional similarity to the newly defined integrin α6β4. Cancer Res 51:2395–2402,1991.
Hynes RO. Integrins: A family of cell surface receptors. Cell 48:549–554, 1987.
Boyce ST, Ham RG. Cultivation, frozen storage, and clonal growth of normal human epidermal keratinocytes in serum-free media. Journal of Tissue Culture Methods 9:83–93,1985.
Sonnenberg A, Janssen H, Hogervorst F, Calafat J, Hilgers J. A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody. J Biol Chem 262:10376–10383, 1987.
Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 162:156–159,1987.
Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual, 2nd ed. New York: Cold Spring Harbor Laboratory Press, 1989.
Barker JNMN, Sanna V, Mitra RS, Dixit V M, Nickoloff BJ. Marked synergism between tumor necrosis factor-a and interferon gin regulation of keratinocyte-derived adhesion molecules and chemotactic factors. J Clin Invest 85:605–608,1990.
Hemler ME, Crouse C, Sonnenberg A. Association of the VLA α6 subunit with a novel protein: A possible alternative to the common VLA β1 subunit on certain cell lines. J Biol Chem 264:6529–6539,1989.
Hogervorst F, Kuikman I, von dem Borne AEG, Sonnenberg A. Cloning and sequence analysis of beta-4 cDNA: An integrin subunit that contains a unique 118 kd cytoplasmic domain. EMBO J 9:765–770, 1990.
Hogervorst F, Kuikman I, van Kessel AG, Sonnenberg A. Molecular cloning of the human α6 integrin subunit and chromosomal location of the α6 and β4 genes. Eur J Biochem, in press.
Birnhorn HC, Doly J. A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res 7:1513, 1979.
Feinberg AP, Vogelstein B. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132:6–13, 1983.
Kidd JG, Rous P. A transplantable rabbit carcinoma originating in a virus-induced papilloma and containing the virus in masked or altered form. J Exp Med 71:813–838, 1940.
Easty DM, Easty GC. Establishment of an in vitro cell line from the rabbit VX2 carcinoma. Virchows Arch 39:333–337,1982.
Georges E, Breitbund F, Jibard N, Orth G. Two Shope papillomavirus-associated VX2 carcinoma cell lines with different levels of keratinocyte differentiation and transplantability. J Virol 55:246–250, 1985.
Osato T, Ito Y. In vitro cultivation and immunolluorescent studies of transplantable carcinomas VX2 and VX7. J Exp Med 126:881–895, 1967.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Carey, T.E. et al. (1992). Culture Conditions Affect Expression of the α6β4 Integrin Associated with Aggressive Behavior in Head and Neck Cancer. In: Newell, G.R., Hong, W.K. (eds) The Biology and Prevention of Aerodigestive Tract Cancers. Advances in Experimental Medicine and Biology, vol 320. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3468-6_10
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3468-6_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6536-5
Online ISBN: 978-1-4615-3468-6
eBook Packages: Springer Book Archive