Delta Virus as a Vector for the Delivery of Biologically-Active RNAs: Possibly a Ribozyme Specific for Chronic Hepatitis B Virus Infection

  • Sen-Yung Hsieh
  • John Taylor
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 312)


RNA species have been designed that demonstrate specific biological activities. Examples include the antisense RNA oligonucleotides (Weintraub et al., 1985) and catalytic RNAs that act as endoribonucleases (Haseloff and Gerlach, 1988). And, recently (Ellington and Szostak 1990) have developed an even more general method of allowing the selection, in the test tube, of RNA species that can bind to a chosen domain, for example on an RNA, DNA, or protein.


Hepatitis Delta Virus Chloramphenicol Acetyl Transferase Woodchuck Hepatitis Virus Specific Biological Activity Thymidine Kinase Promotor 
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  1. Chen, P.J., Kalpana, G., Goldberg, J., Mason, W., Werner, B., Gerin, J., and Taylor, J., 1986, Structure and replication of the genome of hepatitis delta virus, Proc. Natl. Acad. Sci. USA, 83:8774.PubMedCrossRefGoogle Scholar
  2. Ellington and Szostak, 1990, In vitro selection of RNA molecules that bind specific ligands, Nature, 346:818.Google Scholar
  3. Haseloff, J., and Gerlach, W.L., 1988, Simple RNA enzymes with new and highly specific endoribonuclease activities, Nature, 334:585.PubMedCrossRefGoogle Scholar
  4. Kuo, M.Y.-P., Chao, M., and Taylor, J., 1989, Initiation of replication of the human hepatitis delta virus genome from cloned DNA: Role of the delta antigen, J. Virol., 63:1945.PubMedGoogle Scholar
  5. Kuo, M.Y.-P., Goldberg, J., Coates, L., Mason, W., Gerin, J., and Taylor, J., 1988, Molecular cloning of hepatitis delta virus RNA from an infected woodchuck liver: sequence, structure, and application, J. Virol., 62:1855.PubMedGoogle Scholar
  6. Taylor, J., 1990a, The structure and replication of human hepatitis delta virus, Seminars in Virol., 1:135.Google Scholar
  7. Taylor, J., 1990b, Hepatitis delta virus: cis and trans function needed for replication, Cell, 61:371.CrossRefGoogle Scholar
  8. Weintraub, H., Izant, J.G., and Harland, R., 1985, Antisense RNA as a molecular tool for genetic analysis, Trends in Gen., 1:22.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Sen-Yung Hsieh
    • 1
  • John Taylor
    • 1
  1. 1.Fox Chase Cancer CenterPhiladelphiaUSA

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