A Preliminary Report of a Controlled Study of Thymosin Alpha-1 in the Woodchuck Model of Hepadnavirus Infection
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Thymosin alpha-1 (TA1) is one of a family of peptides with immunoregulatory activities which occur naturally in thymic tissues (1). TA1 is an acidic 28 amino acid molecule that is biologically active in a number of in vitro and in vivo assays; it is highly conserved among mammalian species and is available as a chemically-defined synthetic preparation. Detectable levels of TA1 are found in the serum of normal individuals (2). Due to the immunoregulatory properties of thymic peptides, there is current interest in their possible use in the treatment of chronic diseases, including Type B hepatitis (3). In a preliminary report, Mutchnick, et al. (4) described the possible efficacy of thymosin fraction 5 and TA1 in the treatment of patients with chronic active hepatitis due to hepatitis B virus (HBV). The purpose of the current study was to evaluate TA1 in an animal model system of HBV infection and disease.
KeywordsChronic Active Hepatitis Amino Acid Molecule Woodchuck Hepatitis Virus Immunoregulatory Activity Thymic Peptide
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