Abstract
This brief article will focus on the possible role of p21ras in signal transduction. There is a plethora of conflicting information as to its function in cell signaling. Earlier studies suggested that p21ras acted to couple certain membrane receptors to phospholipase C (PLC), which when activated, caused an elevation in inositol phosphates and a subsequent increase in intracellular free calcium ([Ca2+]i). However, more recent studies do not support this notion,1 and suggest that the role of p21ras maybe to alter transcription of transforming genes, thereby coupling hormone receptors to the activity of PLC. Evidence supporting this new concept will be presented.
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Blackmore, P.F. (1992). Role of p21ras in Hormone Signalling and Cell Growth/Transformation. In: Vinik, A.I., Sirman, D.J. (eds) Pancreatic Islet Cell Regeneration and Growth. Advances in Experimental Medicine and Biology, vol 321. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3448-8_15
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DOI: https://doi.org/10.1007/978-1-4615-3448-8_15
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