Abstract
The ß amino acid taurine has many functions. Some functions involve many tissues of vertebrates such as regulation of cellular osmolarity1, while other functions are restricted to a particular cell type such as biliary acid detoxification by hepatocytes2. Uptake and release of taurine has been studied in a variety of cell types. Uptake is linked to the existence of a transport mechanism specific for ß amino acids. This transporter recognizes taurine, ß-alanine3,4 and probably also hypotaurine5.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
N.M. van Gelder, A central mechanism of action for taurine: osmoregulation, bivalent cations, and excitation threshold, Neurochem. Res. 8:687–699 (1983).
C.E. Wright, H.H. Tallan, Y. Lin, and G.E. Gaull, Taurine: biological update, Ann. Rev. Biochem. 55:427–453 (1986).
D.L. Martin and W. Shain, High affinity transport of taurine and ß-alanine and low affinity transport of ry-aminobutyric acid by a single transport system in cultured glioma cells, J. Biol. Chem. 254:7076–7084 (1979).
O.M. Larsson, R. Griffiths, I.C. Allen, and A. Schousboe, Mutual inhibition kinetics analysis of - aminobutyric acid, taurine, and ß-alanine high-affinity transport into neurons and astrocytes: evidence for similarity between the taurine and ß-alanine carriers in both cell types, J. Neurochem. 47:426–432 (1986).
I. Holopainen and P. Kontro, Taurine and hypotaurine transport by a single system in cultured neuroblastoma cells, A. Physiol. Scand 122:381–386 (1984).
R.J. Huxtable, H.E. Laird, and S.E. Lippincott, The transport of taurine in the heart and the rapid depletion of tissue taurine content by guanidinoethyl sulfonate, J. Phannl. Erp. Therap. 211:465–471 (1979).
O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall, Protein measurement with the Folin phenol reagent, J. Biol. Chem. 193:265–275 (1951).
J. Booher and M. Sensenbrenner, Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask cultures, Neurobiology 2:97–105 (1972).
S. Kim, J. Stern, M. Kim, and D. Pleasure, Culture of purified rat astrocytes in serum-free medium supplemented with mitogen, Brain Res. 274:79–86 (1983).
Lleu, P.L. and Rebel, G.,1990, Effect of HEPES on the Na+, Cl--dependent uptake of taurine, and ß-alanine by cultured glial cells. Modulation by composition and osmolarity of medium, Neuropharmacol. 29:719–725.
Lieu, P.L. and Rebel, G., 1989, Effect of HEPES on the taurine uptake by cultured glial cells, J. Neurosci. Res. 23:78–86.
D. Di Scala-Guenot, M.T. Strosser, M.J. Freund-Mercier and Ph. Richard, Characterization of oxytocin-binding sites in primary rat brain cell cultures, Brain Res. 524:10–16 (1990).
J.E. Bottenstein and G.H. Sato, Growth of a rat neuroblastoma cell line in serum-free supplemented medium, Proc. Nat. Acad. Sci. US, 76:514–517 (1979).
U.T. Rüegg and F. Hefti, Growth of dissociated neurons in culture dishes coated with synthetic polymeric amines, Neurosci. Lett. 49:319–324 (1984).
Lelong, I.H., Petegnief, V. and Rebel, G., 1991, Neuronal cells mature faster on polyethyleneimine coated plates than on polylysine plates, J. Neurosci. Res. (submitted).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Rebel, G., Lleu, P.L., Petegnief, V., Frauli-Meischner, M., Guerin, P., Lelong, I.H. (1992). Effect of Hepes on the Uptake of Taurine by Cultured Nervous Cells. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine. Advances in Experimental Medicine and Biology, vol 315. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3436-5_33
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3436-5_33
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6520-4
Online ISBN: 978-1-4615-3436-5
eBook Packages: Springer Book Archive