Abstract
The functional role(s) of taurine in the CNS has not yet been determined unambiguously. However, its absence is known to have a negative impact on brain development, and it has also been implicated in osmotic regulation, neuromodulation and neurotransmission (Huxtable, 1989). Many of these studies have utilized a variety of in vitro preparations from which the release or efflux of preloaded radiolabeled taurine has been monitored in response to a variety of stimuli. The focus of this chapter is on work done in this laboratory following HPLC analysis of the excitatory amino acid agonist evoked release of endogenous taurine from cultured cerebellar neurons containing a mixture of approximately 90% excitatory granule cells and 57% inhibitory (GABAergic) interneurons.
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© 1992 Springer Science+Business Media New York
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Dutton, G.R., Rogers, K.L. (1992). Evoked Endogenous Taurine Release from Cultured Cerebellar Neurons. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine. Advances in Experimental Medicine and Biology, vol 315. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3436-5_32
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DOI: https://doi.org/10.1007/978-1-4615-3436-5_32
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