Abstract
The importance of taurine in the developing brain has already been recognized. A deficiency of taurine in early development has been shown in kittens to interfere with the normal cell migration from the cerebellar granule cell layer, manifesting itself in a nervous system dysfunction.1In immature brain tissue taurine levels are also very high,2,3 and depolarizing concentrations of K+ evoke a strikingly large release of both endogenous and exogenous preloaded taurine.4,5,6 On the other hand, very little is known of the possible functions of taurine in the ageing brain. We have now studied the uptake and the release of endogenous and labeled preloaded taurine in the cerebral cortex of mice during the whole life-span, focusing mainly on changes during ageing.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J.A. Sturman, R.C. Moretz, J.H. French, and H.M. Wisniewski, Taurine deficiency in the developing cat: persistence of the cerebellar external granule cell layer, J. Neurosci. Res. 13:405 (1985).
S.S. Oja and P. Kontro, Taurine, in: “Handbook of Neurochemistry,” 2nd edn, vol. 3, p. 501, A. Lajtha, ed., Plenum, New York (1983).
R.J. Huxtable, Taurine in the central nervous system and the mammalian actions of taurine, Prog. Neurobiol. 32:471 (1989).
P. Kontro and S.S. Oja, Taurine and GABA release from mouse cerebral cortex slices: potassium stimulation releases more taurine than GABA from developing brain, Devl Brain Res.37:277 (1987).
P. Kontro and S.S. Oja, Release of taurine and GABA from cerebellar slices from developing and adult mice, Neuroscience 29:413 (1989).
S.S. Oja and P. Kontro, Release of endogenous taurine andry-aminobutyric acid from brain slices from the adult and developing mouse, J. Neurochem. 52:1018 (1989).
P. Kontro and S.S. Oja, Taurine and GABA binding in mouse brain: effects of freezing, washing and Triton X-100 treatment on membranes, Int. J. Neurosci. 32:881 (1987).
P. Kontro, Comparison of taurine, hypotaurine and ß-alanine uptake in brain synaptosomal preparations from developing and adult mouse, Int. J. Devl Neurosci 2:465 (1984).
S.S. Oja, A.J. Uusitalo, M.-L. Vahvelainen, and R.S. Piha, Changes in cerebral and hepatic amino acids in the rat and guinea pig during development, Brain Res. 11:655 (1968).
JA. Sturman and G.E. Gaull, Taurine in the brain and liver of the developing human and monkey, J. Neurochem. 25:831 (1975).
P. Kontro and S.S. Oja, Taurine efflux from brain slices: potassium-evoked release is greater from immature than mature brain tissue, in: “The Biology of Taurine: Methods and Mechanisms,” p. 79, RJ. Huxtable, F. Franconi and A. Giotti, eds, Plenum, New York (1987).
P. Kontro and S.S. Oja, Release of taurine, GABA and dopamine from rat striatal slices: mutual interactions and developmental aspects, Neuroscience 24:49 (1988).
P. Kontro and S.S. Oja, Taurine and GABA release from mouse cerebral cortex slices: effects of structural analogues and drugs, Neurochem. Res. 12:475 (1987).
E.R. Korpi, P. Kontro, K. Nieminen, K.-M. Marnela, and S.S. Oja, Spontaneous and depolarization-induced efflux of hypotaurine from mouse cerebral cortex slices: comparison with taurine and GABA, Life Sci. 29:811 (1981).
J.-P. Pin, S. Weiss, M. Sebben, D.E. Kemp, and J. Bockaert, Release of endogenous amino acids from striatal neurons in primary culture, J. Neurochem. 47:594 (1986).
P. Saransaari and S.S. Oja, Release of GABA and taurine from brain slices, Prog. Neurobiol. 38:455 (1992).
P. Saransaari and S.S. Oja, Excitatory amino acids evoke taurine release from cerebral cortex slices from adult and developing mice, Neuroscience 45:451 (1991).
G.L. Wenk, L.C. Walker, D.L. Price, and L.C. Cork, Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys, Neurobiol. Aging 12:93 (1991).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Saransaari, P., Oja, S.S. (1992). Taurine Transport in the Mouse Cerebral Cortex during Development and Ageing. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine. Advances in Experimental Medicine and Biology, vol 315. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3436-5_25
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3436-5_25
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6520-4
Online ISBN: 978-1-4615-3436-5
eBook Packages: Springer Book Archive