Abstract
One of the established actions of taurine is the modulation of myocardial contraction. Initial studies demonstrating this effect employed pharmacological doses of taurine to alter contractile function1–3. Although it was assumed that this action of taurine might represent a physiological function, only recently has evidence been obtained confirming this theory. Pion et al.4 reported in 1987 that cats fed a taurine deficient diet developed a cardiomyopathy. More recently, Steele et al.5 and Galler et al.6 found that taurine altered contractile function of skinned muscle fibers, a preparation in which the cell membrane is permeabilized, allowing changes in the intracellular milieu.
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References
J. Dietrich and J. Diacona, Comparison between ouabain and taurine effects on isolated rat and guinea pig hearts in low calcium medium, Life Sci. 10:499–507 (1971).
S.W. Schaffer, J.P. Chovan, and R.F. Werkman, Dissocation of cAMP changes and myocardial contractility in taurine perfused rat heart, Biochem. Biophys. Res. Commun. 81:248–253 (1978).
J.C. Khatter, P.L. Soni, RJ. Hoeschen, L.E. Alto, and N.S. Dhalla, Subcellular effects of taurine on guinea pig heart, in: “The Effects of Taurine on Excitable Tissues,” S.W. Schaffer, S.I. Baskin, and JJ. Kocsis, eds., Spectrum Publications, New York, pp. 281–293 (1981).
P.D. Pion, M.D. Kittleson, Q.R. Rogers, and J.G. Morris, Myocardial failure in cats associated with low plasma taurine: A reversible cardiomyopathy, Science 237:764–768 (1987).
D.S. Steele, G.L. Smith,and DJ. Miller, The effects of taurine on Ca2+ uptake by the sarcoplasmic reticulum and Ca2+ sensitivity of chemically skinned rat heart, J. Physiol. 422:499–511 (1990).
S. Galler, C. Hutzler, and T. Haller, Effects of taurine on Ca2+ -dependent force development of skinned muscle fibre preparations, J. Exp. Biol. 152:255–264 (1990).
J.P. Chovan, E.C. Kulakowski, B.W. Benson, and S.W. Schaffer, Taurine enhancement of calcium binding to rat heart sarcolemma, Biochim. Biophys. Acta 551:129–136 (1979).
S.W. Schaffer, S. Allo, S. Punna, and T. White, Defective response to cAMP-dependent protein kinase in non-insulin-dependent diabetic heart, Am. J. Physiol. 261:E369–E376 (1991).
H. Harada, S. Allo, N. Viyuoh, J. Azuma, K. Takahashi, and S.W. Schaffer, Regulation of calcium transport in drug-induced taurine-depleted hearts, Biochim. Biophys. Acta 944:273–278 (1988).
J.D. Welty and M.C. Welty, Effects of taurine on subcellular calcium dynamics in the normal and cardiomyopathic hamster heart, in: “The Effects of Taurine on Excitable Tissues,” S.W. Schaffer, S.I. Baskin, and JJ. Kocsis, eds., Spectrum Publications, New York, pp. 295–312 (1981).
M.L. Entman, E.P. Bornet, and R. Bressler, The effect of taurine on cardiac sarcoplasmic reticulum, Life Sci. 21:543–550 (1977).
M. Michalak, Identification of the Ca2+ -release activity and ryanodine receptor in sarcoplasmic reticulum membranes during cardiac myogenesis, Biochem. J. 253:631–636 (1988).
H. Harada, BJ. Cusack, R.D. Olson, W. Stroo, J. Azuma, T. Hamaguchi, and S.W. Schaffer, Taurine deficiency and doxorubicin: Interaction with the cardiac sarcolemmal calcium pump, Biochem. Pharmacol. 39:745–751 (1990).
A. Sawamura, N. Sperelakis, J. Azuma, and S. Kishimoto, Effects of taurine on the electrical and mechanical activities of embryonic chick heart, Can. J. Physiol. Phannacol. 64:649–655 (1986).
N. Lake, M. de Roode, and S. Nattel, Effects of taurine depletion on rat cardiac electrophysiology: In vivo and in vitro studies, Life Sci. 40:997–1005 (1987).
N. Sperelakis, T. Yamamoto, G. Bkaily, H. Sada, A. Sawamura, and J. Azuma, Taurine effects on action potentials and ionic currents in chick myocardial cells, in: “Taurine and the Heart,” H. Iwata, J.B. Lombardini, and T. Segawa, eds., Kluwer Academic Publishers, Boston, pp. 119 (1989).
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© 1992 Springer Science+Business Media New York
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Schaffer, S.W., Punna, S., Duan, J., Harada, H., Hamaguchi, T., Azuma, J. (1992). Mechanism Underlying Physiological Modulation of Myocardial Contraction by Taurine. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine. Advances in Experimental Medicine and Biology, vol 315. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3436-5_22
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DOI: https://doi.org/10.1007/978-1-4615-3436-5_22
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