Abstract
Taurine (2-aminoethane sulfonic acid), a ß-amino acid present in human diet, is one of the most abundant sulfur containing amino acids in mammalian tissues, found in excess of 30 µmol/g tissue in rat heart1,2. Taurine exhibits a variety of cardiovascular pharmacological activity, including membrane stabilizing effects, inotropic actions and hypotensive activity. Recently, evidence has been obtained indicating that taurine also attenuates isoprenaline-induced free radical production. Although some investigators have reported that taurine is an antiarrhythmic agent3,4, the precise mechanism underlying this action has not been established. In the present study, we examined the effects of taurine on arrhythmias caused by adrenaline infusion, ischemia-reperfusion injury and veratrine administration in anesthetized rats. We also have explored the relationship between the antiarrhythmic activity of taurine and changes in myocardial cAMP and free radical production.
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References
S.W. Schaffer, E.C. Kulakowski, and J.H. Kramer, Taurine transport by reconstituted membrane vesicles, in: “Taurine in Nutrition and Neurology,”R.J. Huxtable and H. Pasantes-Morales, eds., Plenum Press, New York, pp 143–160 (1982).
R. Huxtable, Metabolism and functions of taurine in the heart, in: “Taurine,”R. Huxtable and A. Barbeau, eds., Raven Press, New York, pp 99–120 (1976).
W.O. Read and J.D. Welty, Effect of taurine on epinephrine and digoxin-induced irregularities of the dog heart, J. Pharmacol. Exp. Therap.139:283–289 (1963).
E.T. Chazov, L.S. Malchikova, N.V. Lipina, G.B. Asafov, and V.M. Smirnov, Taurine and electrical activity of the heart, Circ. Res.34 and 35 (Supp. III):11–12 (1974).
H.J. Mest and W. Foerster, The central nervous effect of prostaglandins I2, E2 and F2a, on aconitine-induced cardiac arrhythmias in rats, Prostaglandins 18:235–238 (1979).
H. Ohkawa, N. Ohnishi, and K. Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction, Anal. Biochem.95:351–358 (1979).
S. Marklund and G. Marklund, Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase, Eur. J. Biochem.47:469–474 (1974).
A.S. Manning and DJ. Hearse, Reperfusion-induced arrhythmias: Mechanisms and prevention,J. Mol. Cell. Cardiol.16:497–518 (1984).
B. Woodward, N. Mohamed, and M. Zakaria, Effect of some free radical scavengers on reperfusioninduced arrhythmias in the isolated rat heart, J.Mol. Cell. Cardiol.17:485–493 (1985).
S.W. Schaffer, J.P Chovan, and R.F. Werkman, Dissociation of cAMP changes and myocardial contractility in perfused rat heart, Biochem. Biophys. Res. Commun.81:248–253 (1978).
S.W. Schaffer, J.H. Kramer, W.G. Lampson, E. Kulakowski, and Y. Sakane, Effect of taurine on myocardial metabolism: Role of calmodulin, in: “Sulfur Amino Acids: Biochemical and Clinical Aspects,” K. Kuriyama, RJ. Huxtable and H. Iwata, eds., Alan R. Liss, Inc., New York, pp 39–50 (1983).
L.S. Malchikova, N.V. Speranskaya, and E.P. Elimrova, Effect of taurine on the cAMP and cGMP content in rat hearts during stress, Medicina (Moscow) 20:133–137 (1979).
L.S. Malchikova and E.P. Elizarova, Taurine and cAMP content in the heart, Medicina (Moscow) 21:85–89 (1981).
K. Kuriyama and E. Ueno, Functional roles of taurine in central nervous system: Possible role as a neuromodulator, Proc 9th Symposium Act. and Mesh (Osaka) S32 (1980).
B. Hue and T. Chanelet, Modulation of acetylcholine release by taurine in the central nervous system of the cockroach, Periplaneta americana L. J. Phannac. Paris 15:65–78 (1981).
A. Lehmann and A. Hamberger, Inhibition of cholinergic response by taurine in frog isolated skeletal muscle, J. Phann. and Pharmacol.36:59–61 (1984).
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© 1992 Springer Science+Business Media New York
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Wang, G.X., Duan, J., Zhou, S., Li, P., Kang, Y. (1992). Antiarrhythmic Action of Taurine. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine. Advances in Experimental Medicine and Biology, vol 315. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3436-5_21
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DOI: https://doi.org/10.1007/978-1-4615-3436-5_21
Publisher Name: Springer, Boston, MA
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