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Interleukin-2 and the Regulation of Activated Macrophage Cytotoxic Activities

  • Chapter
Microbial Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 319))

Abstract

In 1976, Morgan and colleagues reported that conditioned media from mitogen-stimulated mononuclear cells contained a factor which maintained the exponential proliferative growth of human leukemic blood or bone marrow cells (1); the proliferative cells were identified as normal T lymphocytes (2). Isolation, characterization, and subsequent purification of this factor in the conditioned medium lead to the identification of a T cell growth factor (TCGF) now known as IL-2 (3), a glycoprotein of 15.5 kD with a slightly basic isoelectric point (4). Shortly thereafter, Taniguchi et al. (5) isolated a cDNA clone for IL-2. Although IL-2 was initially described as the ultimate mitogenic signal for both antigenically and polyclonally activated T cells, aiding in their cell cycle transition from G1 to S phase (6), subsequent studies showed that IL-2 stimulates NK and LAK cell activity (7, 8), induces B cell differentiation and proliferation (9), and activates macrophage cytotoxicity (10). IL-2 also participates in induction of T cell synthesis of cytokines, such as IFN-γ (11) and B cell growth factor-1, or IL-4 (12).

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References

  1. D. A. Morgan, F. W. Ruscett, and R. C. Gallo, Selective in vitro growth of T lymphocytes from normal human bone marrows, Science 193:1007 (1976).

    Article  PubMed  CAS  Google Scholar 

  2. F. W. Ruscett, D. A. Morgan, and R. C. Gallo, Functional and morphologic characterization of human T cells continuously grown in vitro, J. Immunol. 119:131 (1977).

    Google Scholar 

  3. K. A. Smith, Interleukin-2: Inception, Impact and Implications, Science. 240:1169 (1988).

    Article  PubMed  CAS  Google Scholar 

  4. R. J. Robb and K. A. Smith, heterogeneity of human T cell growth factor due to glycosylation, Mol. Immunol. 18:1087 (1981).

    Article  PubMed  CAS  Google Scholar 

  5. T. Taniguchi, H. Matsui., T. Fujita, C. Takaoka, N. Kashima, R. Yoshimoto, and J. Hamuor, Structure and expression of a cloned cDNA for human interleukin-2, Nature (London) 302:305.

    Google Scholar 

  6. B. M. Stadler, S. F. Dougherty, J. J. Farrar, and J. J. Oppenheim, Relationship of cell cycle recovery of IL-2 activity from human mononuclear cells, human and mouse T cell lines, J. Immunol. 127:1936 (1981).

    PubMed  CAS  Google Scholar 

  7. W. Domzig, B. M. Stadler, and R. B. Herberman, Interleukin-2 dependence of human natural killer (NK) cell activity, J. Immunol. 130:1970 (1983).

    PubMed  CAS  Google Scholar 

  8. C. S. Henney, K. Kuribayashi, D. E. Kern, and S. Gillis, Interleukin-2 augments natural killer cell activity, Nature (London) 291:335 (1981).

    Article  CAS  Google Scholar 

  9. R. J. Robb, Interleukin-2: the molecule and its function, Immunol. Today 5:203. (1984).

    Article  CAS  Google Scholar 

  10. M. Malkovsky, B. Loveland, M. North, G. L. Asherson, L. Gao, P. Ward, and W. Fiers, Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes, Nature 325:262 (1987)

    Article  PubMed  CAS  Google Scholar 

  11. J. J. Farrar, W. R. Benjamin, M. L. Hilfiker, M. Howard, W. L. Farrar, and J. Fuller-Farrar, The biochemistry, biology and role of interleukin-2 in the induction of cytotoxic T cell and antibody-forming B cell responses, Immunol. Rev. 63:129 (1982).

    Article  PubMed  CAS  Google Scholar 

  12. M. Howard, L. Matis, T. R. Malek, E. Shevach, W. Keuk, D. Cohen, K. Nakanishi, and W. E. Paul, Interleukin 2 induces antigen-reactive T cell lines to secrete BCGF-1, J. Exp. Med. 158:2024 (1983).

    Article  PubMed  CAS  Google Scholar 

  13. K. Teshigawara, H-M Wang, K. Kato, and K. A. Smith, Interleukin 2 high-affinity receptor expression requires two distinct binding proteins, J. Exp. Med. 165:223 (1987).

    Article  PubMed  CAS  Google Scholar 

  14. T. Uchiyama, S. Border, and T. A. Waldmann, A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells, J. Immunol. 126:1293 (1981).

    Google Scholar 

  15. W. J. Leonard, J. M. Depper, T. Uchiyama, K. A. Smith, T. A. Waldman, and W. C. Green, A monoclonal antibody that appears to recognize the receptor for human T cell growth factor, Nature 300:267 (1982).

    Article  PubMed  CAS  Google Scholar 

  16. J. H. Kehrl, M. Dukovich, G. Whalen, P. Katz, A. S. Fauci, and W. C. Greene, Novel interleukin 2 (IL-2) receptor appears to mediate IL-2-induced activation of natural killer cells, J. Clin. Invest. 81:200 (1988).

    Article  PubMed  CAS  Google Scholar 

  17. R. J. Robb and W. C. Greene, Internalization of IL-2 is mediated by the beta chain of the high affinity IL-2 receptor, J. Exp. Med. 165:1201 (1987).

    Article  PubMed  CAS  Google Scholar 

  18. L. T. Bich-Thuy, M. Dukovich, N. J. Peffer, A. S. Fauci, J. H. Kehrl, and W. C. Greene, Direct activation of human resting T cells by IL-2: the role of an IL-2 receptor distinct from the tac protein, J. Immunol. 139:1550 (1987).

    PubMed  CAS  Google Scholar 

  19. J. L. Lowenthal and W. C. Greene, Contrasting IL-2 binding properties of alpha (tac) and beta (p70) protein subunits of the human high affinity IL-2 receptor complex, J. Exp. Med. 166:1156 (1987).

    Article  PubMed  CAS  Google Scholar 

  20. T. A. Waldman, C. K. Goldman, R. J. Robb, J. M. Depper, W. J. Leonard, S. O. Sharrow, K. F. Bongiovanni, S. J. Korsmeyer, and W. C. Greene, Expression of interleukin 2 receptors on activated human B cells, J. Exp. Med. 160:1450 (1984).

    Article  Google Scholar 

  21. A. W. Boyd, D. C. Fisher, D. A. Fox, S. F. Schlossman, and L. M. Nadler, Structural and functional characterization of IL 2 receptors on activated human B cells, J. Immunol. 134:2387 (1985).

    PubMed  CAS  Google Scholar 

  22. R. Mittler, P. Rao, G. Olini, E. Westberg, W. Newman, M. Hoffman, and G. Goldstein, Activated human B cells display a functional IL 2 receptor, J. Immunol. 134:2393 (1985).

    PubMed  CAS  Google Scholar 

  23. W. Holter, R. Grunow, H. Stockinger, and W. Knapp, Recombinant interferon-γ induces IL-2 receptors on human peripheral blood monocytes, J. Immunol. 136:2171 (1986).

    PubMed  CAS  Google Scholar 

  24. W. Holter, C. K. Goldman, L. Casabo, D. L. Nelson, W. C. Greene, and T. A. Waldmann, Expression of functional IL 2 receptors by lipopolysaccharide and interferon-γ stimulated human monocytes, J. Immunol. 138:2917 (1987).

    PubMed  CAS  Google Scholar 

  25. W. W. Hancock, W. A. Muller, and R. S. Cotran, Interleukin 2 receptors are expressed by alveolar macrophages during pulmonary sarcoidosis and are inducible by lymphokine treatment of normal human lung macrophages, blood monocytes, and monocyte cell lines, J. Immunol. 138:185 (1987).

    PubMed  CAS  Google Scholar 

  26. G. Steiner, E. Tschachler, M. Tani, T. R. Malek, E. M. Shevach, W. Holter, W. Knapp, K. Wolff, and G. Stingl, Interleukin 2 receptors on cultured murine epidermal Langerhans cells, J. Immunol. 137:155 (1986).

    PubMed  CAS  Google Scholar 

  27. S. M. Wahl, N. McCartney-Francis, D. A. Hunt, P. D. Smith, L. M. Wahl, and I. M. Katona, Monocyte interleukin 2 receptor gene expression and interleukin 2 augmentation of microbicidal activity, J. Immunol. 139:1342 (1987).

    PubMed  CAS  Google Scholar 

  28. W. J. Leonard, M. Kronke, N. J. Peffer, J. M. Depper, and W. C. Greene, Interleukin 2 receptor gene expression in normal human T lymphocytes, Proc. Natl. Acad. Sci. USA 82:6281 (1985).

    Article  PubMed  CAS  Google Scholar 

  29. A. Rambaldi, D. C. Young, F. Herrmann, S. A. Cannistra, and J. D. Griffin, Interferon-γ induces expression of the interleukin 2 receptor gene in human monocytes, Eur. J. Immunol. 17:153. (1987).

    Article  PubMed  CAS  Google Scholar 

  30. I. Espinoza-Delgado, J. R. Ortaldo, R. Winkler-Pickett, K. Sugamura, L. Varesio, and D. L. Longo, Expression and role of p75 interleukin 2 receptor on human monocytes, J. Exp. Med. 171:1821 (1990).

    Article  PubMed  CAS  Google Scholar 

  31. G. W. Cox, B. J. Mathieson, S. L. Giardina, and L. Varesio, Characterization of IL-2 receptor expression and function on murine macrophages, J. Immunol. 145:1719 (1990).

    PubMed  CAS  Google Scholar 

  32. P. D. Smith, D. B. Keister, and C. O. Elson, human host response to Giardia lamblia. I. Spontaneous killing by mononuclear leukocytes in vitro, J. Immunol. 128:1372 (1983).

    Google Scholar 

  33. R. M. Strieter, D. G. Remick, J. P. Lynch, R. N. Spengler, and S. L. Kunkel, Interleukin-2-induced tumor necrosis factor-alpha (TNF-α) gene expression in human alveolar macrophages and blood monocyte, Am. Rev. Resp. Dis. 139:335 (1989).

    Article  PubMed  CAS  Google Scholar 

  34. E. J. Kovacs, B. Brock, L. Varesio, and H. A. Young, IL-2 induction of IL-1 mRNA expression in monocytes: regulation by agents that block second messenger pathways, J. Immunol. 143:3532 (1989).

    PubMed  CAS  Google Scholar 

  35. F. Herrmann, S. A. Cannistra, A. Lindemann, D. Blohm, A. Rambaldi, R. H. Mertelsmann, and J. D. Griffin, Functional consequences of monocyte IL-2 receptor expression: induction of IL-1β secretion by IFN-γ and IL-2, J. Immunol. 142:139 (1989).

    PubMed  CAS  Google Scholar 

  36. C. A. Nacy, B. J. Nelson, S. J. Green, and A. I. Meierovics, Cytokine networks and regulation of macrophage antimicrobial activities, in: “Cellular and Cytokine Networks in Tissue Immunity,” M. S. Meltzer and A. Montovani, eds., Wiley-Liss, Inc., New York, (1991).

    Google Scholar 

  37. J. S. Economou, W. H. McBride, R. Essner, K. Rhoades, S. Golub, E. C. Holmes, and D. L. Morton, Tumour necrosis factor production by IL-2-activated macrophages in vitro and in vivo, Immunology 67:514 (1989).

    PubMed  CAS  Google Scholar 

  38. S. Narumi, J. H. Finke, and T. A. Hamilton, Interferon γ and interleukin 2 synergize to induce selective monokine expression in murine peritoneal macrophages, J. Biol. Chem. 265:7036 (1990).

    PubMed  CAS  Google Scholar 

  39. M. G. Pappas, C. A. Nacy, Antileishmanial activities of macrophages from C3H/HeN and C3H/HeJ mice treated with Mycobacterium bovis strain BCG, Cell. Immunol. 80:217 (1983).

    Article  PubMed  CAS  Google Scholar 

  40. C. A. Nacy, M.S. Meltzer, E. J. Leonard, and D. J. Wyler, Intracellular replication and lymphokine-induced destruction of Leishmania tropica in C3H/HeN mouse macrophages, J. Immunol. 127:2381 (1981).

    PubMed  CAS  Google Scholar 

  41. H. C. Miller and D. W. Twohy, Cellular immunity to Leishmania donovani in macrophages in cultures, J. Parasitol. 55:200 (1969).

    Article  PubMed  CAS  Google Scholar 

  42. C. A. Nacy and M. S. Meltzer, Macrophages in resistance to rickettsial infection: macrophage activation in vitro for killing Rickettsia tsutsugamushi. J. Immunol. 123:2544 (1979).

    PubMed  CAS  Google Scholar 

  43. S. B. Salvin and S.-L. Cheng, Lymphoid cells in delayed-type hypersensitivity II. in vitro phagocytosis and cellular immunity, Infect. Immun. 3:548 (1971).

    PubMed  CAS  Google Scholar 

  44. R. Hoff, Killing in vitro of Trypanosoma cruzi by macrophages from mice immunized with T. cruzi or BCG, and absence of cross immunity on challenge in vivo, J. Exp. Med. 142:299 (1975).

    Article  PubMed  CAS  Google Scholar 

  45. M. A. Horwitz and S. C. Silverstein, Activated human monocytes inhibit the intracellular multiplication of Legionnaires’ disease bacteria, J. Exp. Med. 154:1618 (1981).

    Article  PubMed  CAS  Google Scholar 

  46. C. A. Nacy and M. S. Meltzert Macrophages in resistance to rickettsial infection: strains of mice susceptible to the lethal effects of Richettsia akari infection show defective microbicidal activity in vitro, Infect. Immun. 126:204 (1981).

    CAS  Google Scholar 

  47. M. Belosevic, D. S. Finbloom, M. S. Meltzer and C. A. Nacy, IL-2: A cofactor for induction of activated macrophage resistance to infection, J. Immunol. 145:831 (1990).

    PubMed  CAS  Google Scholar 

  48. C. A. Nacy, C. N. Oster, S. L. James, and M. S. Meltzer, Activation of macrophages for destruction of intracellular and extracellular parasites, Contemp. Top. Immunobiol. 13:147 (1984).

    PubMed  CAS  Google Scholar 

  49. C. A. Nacy, E. J. Leonard, and M. S. Meltzer, Macrophages in resistance to rickettsial infections: characterization of the lymphokines that induce rickettsiacidal activity in macrophages, J. Immunol. 126:204 (1981).

    PubMed  CAS  Google Scholar 

  50. M. Belosevic, C. E. Davis, M. S. Meltzer, and C. A. Nacy, Regulation of macrophage antimicrobial activities: identification of lymphokines that cooperate with IFN-γ for induction of resistance to infection, J. Immunol. 141:890 (1988).

    PubMed  CAS  Google Scholar 

  51. C. E. Davis, M. Belosevic, M. S. Meltzer, and C. A. Nacy, Regulation of activated macrophage antimicrobial activities: cooperation of lymphokines for induction of resistance to infection, J. Immunol. 141:627 (1988).

    PubMed  CAS  Google Scholar 

  52. P. Ralph, C. A. Nacy, M. S. Meltzer, N. Williams, I. Nakionz, and E. J. Leonard, Colony stimulating factors and regulation of macrophage tumoricidal and microbicidal activities, Cell Immun. 76:10 (1983).

    Article  CAS  Google Scholar 

  53. C. A. Nacy, A. I. Meierovics, M. Belosevic, and S. J. Green, TNF-α: central regulatory cytokine in the induction of macrophage antimicrobial activities, Pathobiol. 59:182 (1991).

    Article  CAS  Google Scholar 

  54. T. A. Hamilton, D. A. Becton, S. D. Somers, and D. O. Adams, Interferon γ modulates protein kinase C activity in murine peritoneal macrophages, J. Biol. Chem. 260:1378 (1985).

    PubMed  CAS  Google Scholar 

  55. D. A. Becton, D. O. Adams, and T. A. Hamilton, Characterization of protein kinase C activity in interferon γ-treated murine peritoneal macrophages, J. Cell. Physiol. 125:485 (1986).

    Article  Google Scholar 

  56. M. Belosevic and C. A. Nacy, Interleukin-2, Anti-interleukin-2 receptor antibody, and activation of macrophages, Cell. Immunol. 128:635 (1990).

    Article  PubMed  CAS  Google Scholar 

  57. G. Ortega, R. J. Robb, E. M. Shevach, and T. R. Malek, The murine IL-2 receptor I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells, J. Immunol. 133:1970 (1984).

    PubMed  CAS  Google Scholar 

  58. T. R. Malek, R. J. Robb, and E. M. Shevach, Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin-2 receptor ligand complex, Proc. Nat. Acad. Sci. USA 80:5694 (1983).

    Article  PubMed  CAS  Google Scholar 

  59. C. N. Oster and C. A. Nacy, Macrophage activation to kill Leishmania tropica: kinetics of macrophage response to lymphokines that induce microbicidal activities against Leishmania tropica amastigotes, J. Immunol. 132:1492 (1984).

    Google Scholar 

  60. R. M. Crawford, A. H. Fortier, M. Belosevic, and C. A. Nacy, Macrophage Killing Mechanisms, in: “Immunopharmacology,” T. J. Rogers and S. C. Gelman, eds., Telford Press, NJ (1990).

    Google Scholar 

  61. A. H. Fortier, S. J. Green, T. Polsinelli, and C. A. Nacy, Murine peritoneal macrophage interactions with Francisella tularensis live vaccine strain: characterization of growth and interferon-γ induced inhibition of growth in vitro (in preparation).

    Google Scholar 

  62. L. P. Ruco and M. S. Meltzer, Macrophage activation for tumor cytotoxicity: increased lymphokine responsiveness of peritoneal macrophages during acute inflammation, J. Immunol. 120:1054 (1978).

    PubMed  CAS  Google Scholar 

  63. D. L. Hoover and C. A. Nacy, Macrophage activation to kill Leishmania tropica: defective intracellular killing of amastigotes by macrophages elicited with sterile inflammatory agents, J. Immunol. 132:1487 (1984).

    PubMed  CAS  Google Scholar 

  64. S. J. Green, M. S. Meltzer, J. B. Hibbs, Jr., and C. A. Nacy, Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism, J. Immunol. 144:278 (1990).

    PubMed  CAS  Google Scholar 

  65. L. P. Ruco and M. S. Meltzer, Macrophage activation for tumor cytotoxicity: development of macrophage cytotoxic activity requires completion of a sequence of short-lived intermediary reaction, J. Immunol. 121:2035 (1978).

    PubMed  CAS  Google Scholar 

  66. S. J. Green, R. M. Crawford, J. T. Hockmeyer, M. S. Meltzer, and C. A. Nacy, Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-γ-stimulated macrophages by induction of tumor necrosis factor-α, J. Immunol. 145:4290 (1990).

    PubMed  CAS  Google Scholar 

  67. B. J. Nelson, P. Ralph, S. J. Green, and C. A. Nacy, Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-β1, J. Immunol. 146:1849 (1991).

    PubMed  CAS  Google Scholar 

  68. C. A. Nacy, Macrophage activation to kill Leishmania tropica: characterization of a T cell derived factor that suppresses lymphokine-induced intracellular destruction of amastigotes, J. Immunol. 133:448 (1984).

    PubMed  CAS  Google Scholar 

  69. M. S. Meltzer, W. R. Benjamin, and J. J. Farrar, Macrophage activation for tumor cytotoxicity: induction of macrophage tumoricidal activity by lymphokines from EL-4 fluids, a continuous T cell line, J. Immunol. 129:2802 (1982).

    PubMed  CAS  Google Scholar 

  70. M. L. Hilfiker, R. N. Moore, and J. J. Farrar, Biological properties of chromatographically separated murine thymoma derived interleukin 2 and colony-stimulating factor. J. Immunol. 127:1983 (1981).

    PubMed  CAS  Google Scholar 

  71. M. Howard, J. Farrar, M. Hilfiker, B. Johnson, and W. Paul, Identification of a T-cell derived B-cell growth factor distinct from interleukin 2, J. Exp. Med. 155:914 (1982).

    Article  PubMed  CAS  Google Scholar 

  72. J. J. Farrar, J. Fuller-Farrar, P. L. Simon, M. L. Hilfiker, B. M. Stadler, and W. L. Farrar, Thymoma production of T cell growth factor (interleukin 2), J. Immunol. 125:2555 (1982).

    Google Scholar 

  73. B. J. Nelson, J. Rossio, and C. A. Nacy, The EL-4 suppressor factor that blocks development of macrophage intracellular killing activities works through the induction of TGF-β-1, (in preparation).

    Google Scholar 

  74. N. E. Reiner and J. H. Finke, Interleukin 2 deficiency in murine leishmaniasis donovani and its relationship to depressed spleen cell responses to phytohemagglutinin, J. Immunol. 131:1487 (1983).

    PubMed  CAS  Google Scholar 

  75. E. Cillari, F. Y. Liew, and R. Lelchuk, Suppression of interleukin 2 production by macrophages in genetically susceptible mice infected with Leishmania major, Infect. Immun. 54:386 (1983).

    Google Scholar 

  76. A. Harell-Bellani, A. Joskowitz, D. Fradelizi, and H. Elsen, Modification of T cell proliferation and interleukin 2 production in mice infected with Trypanosoma cruzi. Proc. Natl. Acad. Sci. USA 80:3466 (1983).

    Article  Google Scholar 

  77. R. Lelchuk, R. Rose, and J. H. L. Playfair, Changes in the capacity of macrophages and T cells to produce interleukins during murine malaria infection, Cell. Immunol. 84:253 (1983).

    Article  Google Scholar 

  78. V. Coolizi, In vivo and in vitro administration of interleukin 2-containing preparation reverses T cell responsiveness in Mycobacterium bovis BCG-infected mice. Infect. Immun. 45:25 (1984).

    Google Scholar 

  79. S. R. Watson, S. K. Schmitt, D. E. Hendricks, and W. E. Bullock, Immunoregulation in disseminated murine histoplasmosis: disturbances in the production of interleukins 1 and 2, J. Immunol. 135:3487 (1985).

    PubMed  CAS  Google Scholar 

  80. G. Kaplan, D. E. Weinstein, R. M. Steinman, W. R. Lewis, U. Elvers, M. E. Patattoyo, and Z. A. Cohn, An analysis of in vitro T cell responsiveness in lepromatous leprosy, J. Exp. Med. 162:917 (1985).

    Article  PubMed  CAS  Google Scholar 

  81. A. Harengowoin, T. Godal, A. S. Mustafa, A. Belehn, and T. Yemaneberhan, T cell conditioned media reverse T cell unresponsiveness in lepromatous leprosy, Nature 303:342 (1985).

    Article  Google Scholar 

  82. S. D. Sharma, J. M. Hofflin, and J. S. Remington, In vivo recombinant interleukin 2 administration enhances survival against a lethal challenge with Toxoplasma gondii. J. Immunol. 135:4160 (1985).

    PubMed  CAS  Google Scholar 

  83. M. A. Cheever, P. D. Greenberg, A. Fefer, and S. Gillis, Augmentation of the anti-tumor therapeutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleukin 2, J. Exp. Med. 155:968 (1983).

    Article  Google Scholar 

  84. M. Malkovsky, P. D. Medawar, F. R. S. Hunt, L. Palmer, and C. Dore, A diet enriched in vitamin A acetate or in vivo administration of interleukin 2 can counteract a tolerigenic stimulus, Proc. R. Soc. Lond. (Biol.) 220:439 (1984).

    Article  CAS  Google Scholar 

  85. H. Wagner, C. Hardt, K. Heeg, M. Rolinghoff, and K. Pfizenmaier, T cell-derived helper factor allows in vivo induction of cytotoxic T cells in nu/nu mice, Nature 284:278 (1980).

    Article  PubMed  CAS  Google Scholar 

  86. S. N. Hafeneider, P. J. Conlon, C. S. Henney, and S. Gillis, In vivo interleukin 2 administration augments the generation of alloreactive T lymphocytes and resident natural killer cells, J. Immunol. 130:222 (1983).

    Google Scholar 

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  1. Walter Reed Army Institute of Research, Washington, DC, USA

    Barbara J. Nelson, Shawn J. Green, Jim Turpin & Carol A. Nacy

  2. University of Alberta, Edmonton, Alberta, Canada

    Miodrag Belosevic

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    Herman Friedman  & Thomas W. Klein  & 

  2. Teikyo University School of Medicine, Tokyo, Japan

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Nelson, B.J., Belosevic, M., Green, S.J., Turpin, J., Nacy, C.A. (1992). Interleukin-2 and the Regulation of Activated Macrophage Cytotoxic Activities. In: Friedman, H., Klein, T.W., Yamaguchi, H. (eds) Microbial Infections. Advances in Experimental Medicine and Biology, vol 319. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3434-1_9

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