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Multiple Immunological Functions of Extracts from the Cone of Japanese White Pine, Pinus Parviflora Sieb. et Zucc

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Microbial Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 319))

Abstract

Japanese folklore suggests a therapeutic capacity of the extract of the pine cone of Pinus parviflora Sieb, et Zucc. for gastric cancer. We partially purified the antitumor substances (Fr. VI and Fr. VII) by acid- and ethanol- precipitation from the NaOH extract (1). It was unexpectedly found that the replication of human immunodeficiency virus (HIV) was potently inhibited by these fractions (2, 3). We report here their structural analysis and ability to induce several kinds of interesting biological activities.

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References

  1. H. Sakagami, M. Ikeda, S. Unten, K. Takeda, J. Murayama, A. Hamada, K. Kimura, N. Komatsu, and K. Konno, Antitumor activity of polysaccharide fractions from pine cone extract of Pinus parviflora Sieb, et Zucc., Anticancer Res. 7:1153 (1987).

    PubMed  CAS  Google Scholar 

  2. P. K. Lai, J. Donovan, H. Takayama, H. Sakagami, A. Tanaka, K. Konno, and M. Nonoyama, Modification of human immunodeficiency viral replication by pine conce extracts, AIDS Res. Human Retroviruses 6:205 (1990).

    Article  CAS  Google Scholar 

  3. H. Takayama, G. Bradley, P. K. Lai, Y. Tamura, H. Sakagami, A. Tanaka, and M. Nonoyama, Inhibition of human immunodeficiency virus forward and reverse transcription by PC6, a natural product from cones of pine trees, AIDS Res. Hum. Retroviruses 7:349 (1991).

    Article  PubMed  CAS  Google Scholar 

  4. H. Sakagami, T. Oh-hara, T. Kaiya, Y. Kawazoe, M. Nonoyama, and K. Konno, Molecular species of the antitumor and antiviral fraction from pine cone extract, Anticancer Res. 9:1593 (1989).

    PubMed  CAS  Google Scholar 

  5. Y. Tamura, P. K. Lai, W. G. Bradley, K. Konno, A. Tanaka, and M. Nonoyama, A soluble factor induced by an extract from Pinus parviflora Sieb et Zucc can inhibit the replication of human immunodeficiency virus in vitro, Proc. Natl. Acad. Sci. USA 88:2249 (1991).

    Article  PubMed  CAS  Google Scholar 

  6. K. Nagata, H. Sakagami, H. Harada, M. Nonoyama, A. Ishihama, and K. Konno, Inhibition of influenza virus infection by pine cone antitumor substances, Antiviral Res. 13:11 (1990).

    Article  PubMed  CAS  Google Scholar 

  7. K. Fukuchi, H. Sakagami, M. Ikeda, Y. Kawazoe, T. Oh-hara, K. Konno, S. Ichikawa, N. Hata, H. Kondo, and M. Nonoyama, Inhibition of herpes simplex virus infection by pine cone antitumor substances, Anticancer Res. 9:313 (1989).

    PubMed  CAS  Google Scholar 

  8. T. Oh-hara, H. Sakagami, Y. Kawazoe, T. Kaiya, N. Komatsu, N. Ohsawa, M. Fujimaki, S. Tanuma, and K. Konno, Antimicrobial spectrum of lignin-related pine cone extracts of Pinus parviflora Sieb, et Zucc, In Vivo 4:7 (1990).

    PubMed  CAS  Google Scholar 

  9. H. Harada, H. Sakagami, K. Konno, T. Sato, N. Osawa, M. Fujimaki, and N. Komatsu, Induction of antimicrobial activity by antitumor substances from pine cone extract of Pinus parviflora Sieb. et Zucc., Anticancer Res. 8:581 (1988).

    PubMed  CAS  Google Scholar 

  10. M. Abe, K. Okamoto, K. Konno, and H. Sakagami, Induction of antiparasite activity by pine cone lignin-related substances, In Vivo 3:359 (1989).

    PubMed  CAS  Google Scholar 

  11. T. Oh-hara, Y. Ikeda, H. Sakagami, K. Konno, T. Kaiya, K. Kohda, and Y. Kawazoe, Lignified natural products as potential medicinal resources, I. Potentiation of hemolytic plaque-forming cell production in mice, Chem. Pharm. Bull. 38:282 (1990).

    Article  PubMed  CAS  Google Scholar 

  12. H. Sakagami, S. Kohno, S. Tanuma, and Y. Kawazoe, Induction of cytotoxic factor in mice by lignified materials combined with OK-432 (Picibanil), In Vivo 4:371 (1990).

    PubMed  CAS  Google Scholar 

  13. A. Hanaoka, H. Sakagami, and K. Konno, Pine cone antitumor substances stimulate cytotoxic factor production in young mice, but not in aged or tumor-bearing mice, Showa Univ. J. Med. Sci. 1:57 (1989).

    Google Scholar 

  14. K. Kikuchi, H. Sakagami, S. Fujinaga, Y. Kawazoe, T. Oh-hara, S. Ichikawa, Y. Kurakata, M. Takeda, and T. Sato, Stimulation of mouse peritoneal macrophages by lignin-related substances, Anticancer Res. 11:841 (1991).

    PubMed  CAS  Google Scholar 

  15. S. Unten, H. Sakagami, and K. Konno, Stimulation of granulocytic cell iodination by pine cone antitumor substances, J. Leukocyte Biol. 45:168 (1989).

    PubMed  CAS  Google Scholar 

  16. Y. Kurakata, H. Sakagami, M. Takeda, K. Konno, K. Kitajima, S. Ichikawa, N. Hata, and T. Sato, Mitogenic activity of pine cone extracts against cultured splenocytes from normal and tumor-bearing animals, Anticancer Res. 9:961 (1989).

    PubMed  CAS  Google Scholar 

  17. H. Harada, H. Sakagami, K. Nagata, T. Oh-hara, Y. Kawazoe, A. Ishihama, N. Hata, Y. Misawa, H. Terada, and K. Konno, Possible involvement of lignin structure in anti-influenza virus activity, Antiviral Res. 15:41 (1991).

    Article  PubMed  CAS  Google Scholar 

  18. H. Sakagami, Y. Kawazoe, T. Oh-hara, K. Kitajima, Y. Inoue, S. Tanuma, S. Ichikawa, and K. Konno, Stimulation of human peripheral blood polymorpho-nuclear cell iodination by lignin-related substances, J. Leukocyte Biol. 49:277 (1991).

    PubMed  CAS  Google Scholar 

  19. H. Sakagami, K. Nagata, A. Ishihama, T. Oh-hara, and Y. Kawazoe, Antiinfluenza virus activity of synthetically polymerized phenylpropenoids, Biochem. Biophys. Res. Commun. 172:1267 (1990).

    Article  PubMed  CAS  Google Scholar 

  20. H. Sakagami, T. Oh-hara, K. Kohda, and Y. Kawazoe, Lignified materials as a potential medicinal resource. IV. Dehydrogenation polymers of some phenylpropenoids and their capacity to stimulate polymorphonuclear cell iodination, Chem. Pharm. Bull. 39:950 (1991).

    Article  PubMed  CAS  Google Scholar 

  21. S. J. Klebanoff, Myeloperoxidase-halide-hydrogen peroxide antibacterial system, J. Bact. 95:2131 (1968)

    PubMed  CAS  Google Scholar 

  22. T. Oh-hara, Y. Kawazoe, and H. Sakagami, Lignified materials as potential medicinal resources. III. Diversity of biological activity and possible molecular species involved, Chem. Pharm. Bull. 38:3131 (1990).

    Google Scholar 

  23. H. Sakagami, Y. Kawazoe, N. Komatsu, A. Simpson, M. Nonoyama, K. Konno, T. Yoshida, Y. Kuroiwa, and S. Tanuma, Antitumor, antiviral and immunopotentiating activities of pine cone extracts: Potential medicinal efficacy of natural and synthetic lignin-related materials (Review). Anticancer Res. 11:881 (1991).

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Showa University School of Medicine, Tokyo, Japan

    Hiroshi Sakagami

  2. Jonan Hospital, Tokyo, Japan

    Kunio Konno

  3. Nagoya City University, Nagoya, Japan

    Yutaka Kawazoe

  4. Tampa Bay Research Institute, St. Petersburg, Florida, USA

    Patrick Lai & Meihan Nonoyama

Authors
  1. Hiroshi Sakagami
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  2. Kunio Konno
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  3. Yutaka Kawazoe
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  4. Patrick Lai
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  5. Meihan Nonoyama
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Editor information

Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Herman Friedman  & Thomas W. Klein  & 

  2. Teikyo University School of Medicine, Tokyo, Japan

    Hideyo Yamaguchi

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© 1992 Springer Science+Business Media New York

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Sakagami, H., Konno, K., Kawazoe, Y., Lai, P., Nonoyama, M. (1992). Multiple Immunological Functions of Extracts from the Cone of Japanese White Pine, Pinus Parviflora Sieb. et Zucc . In: Friedman, H., Klein, T.W., Yamaguchi, H. (eds) Microbial Infections. Advances in Experimental Medicine and Biology, vol 319. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3434-1_33

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  • DOI: https://doi.org/10.1007/978-1-4615-3434-1_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6519-8

  • Online ISBN: 978-1-4615-3434-1

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