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Microbial Infections pp 319–330Cite as

Effects of Medicinal Plants on Hemopoietic Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 319))

Abstract

It has been found that Juzentaihoto (TJ-48), one of the traditional Japanese kampo (herbal) medicines, improves the general condition of cancer patients receiving chemotherapy and radiation therapy. We analyze how TJ-48 elicits such effect, and show that oral administration of TJ-48 accelerates recovery from hemopoietic injury induced by radiation and the anti-cancer drug mitomycin C. The effects are found to be due to its stimulation of spleen colony-forming units. Based on the present findings, we propose that the administration of TJ-48 should be of benefit to patients receiving chemotherapy, radiation therapy or bone marrow transplantation.

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Author information

Authors and Affiliations

  1. 1st Department of Pathology, Kansai Medical University Moriguchi, Osaka, 570, Japan

    Susumu Ikehara, Hiroko Hisha, Ryoji Yasumizu & Yoko Ohnishi-Inoue

  2. Tsumura Research Institute for Pharmacology, Ibaraki, 300-11, Japan

    Hideki Kawamura, Yasuhiro Komatsu & Masaki Aburada

  3. Oriental Medicine Research Center of the Kitasato, Institute Minato-ku, Tokyo, 108, Japan

    Haruki Yamada, Hiroaki Kiyohara & Masumi Hirano

  4. All Children’s Hospital, University of South Florida, St. Petersburg, FL, 33701, USA

    Robert A. Good

Authors
  1. Susumu Ikehara
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  2. Hideki Kawamura
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  3. Yasuhiro Komatsu
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  4. Haruki Yamada
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  5. Hiroko Hisha
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  6. Ryoji Yasumizu
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  7. Yoko Ohnishi-Inoue
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  8. Hiroaki Kiyohara
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  9. Masumi Hirano
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  10. Masaki Aburada
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  11. Robert A. Good
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Editor information

Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Herman Friedman  & Thomas W. Klein  & 

  2. Teikyo University School of Medicine, Tokyo, Japan

    Hideyo Yamaguchi

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© 1992 Springer Science+Business Media New York

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Ikehara, S. et al. (1992). Effects of Medicinal Plants on Hemopoietic Cells. In: Friedman, H., Klein, T.W., Yamaguchi, H. (eds) Microbial Infections. Advances in Experimental Medicine and Biology, vol 319. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3434-1_32

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  • DOI: https://doi.org/10.1007/978-1-4615-3434-1_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6519-8

  • Online ISBN: 978-1-4615-3434-1

  • eBook Packages: Springer Book Archive

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