Abstract
Salmonella typhimurium as well as Salmonella enteritidis are thought to be facultative pathogens and are natural causative agents of systemic infection in mice (1). When a virulent strain of Salmonella infects mice, the organisms multiply in the phagocytic cells, especially in the spleen and liver, and can kill the mice within a week. Phagocytic cells play an important role in the innate resistance of mice to infection by Salmonella. The outcome of an infection is influenced by a number of factors, ranging from how the microorganisms are handled by phagocytic cells during the earliest phase of infection, to the appearance of specific cellular and humoral immune responses in the latter phases of infection. The initial control of S. typhimurium proliferation in the host presumably depends on an inherent property of macrophages (2–4) and on macrophage activation (5).
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© 1992 Springer Science+Business Media New York
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Nakano, M., Onozuka, K., Yamasu, H., Zhong, W.F., Nakano, Y. (1992). Protective Effects of Cytokines in Murine Salmonell. In: Friedman, H., Klein, T.W., Yamaguchi, H. (eds) Microbial Infections. Advances in Experimental Medicine and Biology, vol 319. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3434-1_10
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DOI: https://doi.org/10.1007/978-1-4615-3434-1_10
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