Abstract
The etiology of Alzheimer’s disease is still unknown, though several hypotheses have been proposed involving genetic factors, the immune system, metal intoxication, infection and other factors. After the recognition of transmissible nature of Creutzfeldt-Jakob disease (1), transmission studies of Alzheimer’s disease have been tried by several investigators, but none have succeeded in transmitting Alzheimer’s disease to convenient laboratory animals using diseased brain tissue (2,3).
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References
Prunsiner SB: Some speculations about prion, amyloid and Alzheimer’s disease. N Engl J Med 1984, 310, 661–664.
Goudsmit J., Morrow CH, Asher DM, Yanagihara RT, Masters CL, Gibbs CJ, Gajdusek DC: Evidence for and against the transmissibility of Alzheimer’s disease. Neurology 1980, 30, 645–950.
Manuelidis EE: Creutzfeldt-Jakob disease. J. Neuropathol Exp Neurol 1985, 44, 1– 17.
Reisberg B, et al.: The global deterioration scale for assessment of primary degenerative dementia. Am J Psychiatry 1982, 139, 1136–1139.
Manuelidis EE, De Figueiredo JM, Kim JH, Fritch WW, Manuelidis L: Transmission studies from blood of Alzheimer disease patients and health relatives. Proc Natl Acad Sci USA 1988, 85, 4898–4901.
Takeda M, Nishimura T, Kudo T, Tanimukai S, Tada K: Buffy coat from families of Alzheimer’s disease patients produces intracytoplasmic neurofilament accumulation in hamster brain. Brain Res 1991, 551, 319–321.
Takeda M, Nishimura, Tada K. Kudo T, Tanimukai S: Inoculation study of Alzheimer buffy coat into hamster brain. Dementia 1991, 2, 57–63.
Takeda M, Nishimura T., Kudo T, Tanimukai S, Gotow T, Tanabe H, Miki T, Nakamura Y, Niigawa H., Morita H, Tanaka T, Tatebayashi Y, Tada K: Characterization of intracytoplasmic neurofilament accumulation in hamster brain caused by Alzheimer buffy coat inoculation: comparison with experimental neurofibrillary changes produced by aluminum intoxication. Gerontology 1991, 37 (suppl. 1), 31–42.
Takeda M, Nishimura T., Kudo T, Tanimukai S, Gotow T, Tanabe H, Miki T, Nakamura Y, Niigawa H., Morita H, Tanaka T, Tatebayashi Y, Tada K: Characterization of intracytoplasmic neurofilament accumulation in hamster brain caused by Alzheimer buffy coat inoculation: comparison with experimental neurofibrillary changes produced by aluminum intoxication. Gerontology 1991, 37 (suppl. 1), 31–42.
Takeda M, Nishimura T., Kudo T, Tanimukai S, Gotow T, Tanabe H, Miki T, Nakamura Y, Niigawa H., Morita H, Tanaka T, Tatebayashi Y, Tada K: Characterization of intracytoplasmic neurofilament accumulation in hamster brain caused by Alzheimer buffy coat inoculation: comparison with experimental neurofibrillary changes produced by aluminum intoxication. Gerontology 1991, 37 (suppl. 1), 31–42.
Kosik KS, Joachim CL, Selkoe DJ: Microtubule-associated protein tau is a major antigenic component of pared helical filaments in Alzheimer’s disease. Proc Natl Acad Sci USA 1986, 83, 4044–4048.
Perry G, Rizzuto N, Autilio-Gambetti L, Gambetti P: Paired helical filaments from Alzheimer disease patients contain cytoskeletal components. Proc Natl Acad Sci USA 1985, 82, 3916–3920.
Schmidt ML, Lee VMY, Trojanowsky JQ: Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles. Am J Pathology 1990, 136, 1069–1075.
Schmidt ML, Lee VMY, Trojanowski JQ: Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer’s disease senile plaque neuntes and neuropil threads. Lab Invest 1991, 64, 352–357.
Pogacar S, Rubio A: Morphological features of Pick’s and atypical Alzheimer’s disease in Down syndrome. Acta Neuropathol 1982, 58, 249–254.
Hirano A, Tuazon R, Zimmerman HM: Neurofibrillary changes, granulovascular bodies and argentophilic globules observed in tuberous sclerosis. Acta Neuropathol 1968, 11, 257–261.
Lampert PW, Earle KM, Gibbs CR Jr, Gajdisek DC: Experimental kuru encephalopathy in chimpanzees and spider monkeys. J Neuropathol Exp Neurol 1969, 28, 353–370.
Beck E, Daniel PM: Kuru and Creutzfeldt-Jakob disease: neuropathological lesions and their significance, in Prusiner SB & Hadlaw WJ (eds) “Slow Transmissible Diseases of the Nervous System” Vol 1, Academic Press, New York, 1979, pp. 257– 270.
Dickson DW, Yen S-H, Suzuki KI, Davies P, Garcia JH, Hirano A: Ballooned neurons in selected neurodegenerative diseases contain phosphorylated neurofilament epitopes. Acta Neuropathol 1986, 71, 216–223.
Ball MJ: Topography of Pick inclusion bodies in hippocampi of demented patients, A quantitative study. J Neuropathol Exp Neurol 1979, 38, 614–620.
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© 1992 Springer Science+Business Media New York
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Takeda, M. et al. (1992). Transmission Study of Neurofilament Pathology in Hamster Brain Produced by Alzheimer Buffy Coat Inoculation. In: Meyer, E.M., Simpkins, J.W., Yamamoto, J., Crews, F.T. (eds) Treatment of Dementias. Advances in Behavioral Biology, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3432-7_37
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DOI: https://doi.org/10.1007/978-1-4615-3432-7_37
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