The possibility of introducing macromolecules across plasma membranes directly into cells to counteract neuropathological processes is an intriguing one that has received increased attention only recently (e.g., 1,2). Of particular interest is the possibility of incorporating normal allelic genes into cells to replace defective ones or to increase the gene dosage for those proteins rendered hypofunctional by disease. Ideally, chronic conditions such as Alzheimer’s disease will eventually be treatable with specific replacement of those cellular constituents that are depleted by or responsible for the symptomology of the disease.
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Meyer, E.M., Pruysers, C.R., de Fiebre, C.M., Bryant, S.O. (1992). Sendai Virosome Envelopes for the Infusion of Macromolecules Into Brain Neurons and Glia. In: Meyer, E.M., Simpkins, J.W., Yamamoto, J., Crews, F.T. (eds) Treatment of Dementias. Advances in Behavioral Biology, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3432-7_25
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